公开(公告)号：US20090264455A9

公开(公告)日：2009-10-22

申请号：US11883247

申请日：2006-06-12

Applicant: Bijan Pedram ,  Cornelis Arjan Van Oeveren ,  Lin Zhi ,  Shuo Zhao ,  Yixing Shen

Inventor： Bijan Pedram ,  Cornelis Arjan Van Oeveren ,  Lin Zhi ,  Shuo Zhao ,  Yixing Shen

IPC: A61K31/437 ,  C07D471/04 ,  C07K14/71 ,  C12N5/06 ,  C12Q1/02 ,  A61P19/08 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.

公开(公告)号：US07084151B2

公开(公告)日：2006-08-01

申请号：US10684227

申请日：2003-10-10

Applicant: Lin Zhi ,  Cornelis Arjan Van Oeveren

Inventor： Lin Zhi ,  Cornelis Arjan Van Oeveren

IPC: A61K31/4741 ,  C07D491/02

CPC classification number: C07D491/04 ,  G01N33/743

Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.

Abstract translation: 本发明涉及用于调节由孕酮受体介导的过程的化合物，药物组合物和方法。 还提供了制备这些化合物和药物组合物的方法。

公开(公告)号：US07026484B2

公开(公告)日：2006-04-11

申请号：US10080926

申请日：2002-02-22

Applicant: Lin Zhi ,  Cornelis Arjan Van Oeveren ,  Jyun-Hung Chen ,  Robert I. Higuchi

Inventor： Lin Zhi ,  Cornelis Arjan Van Oeveren ,  Jyun-Hung Chen ,  Robert I. Higuchi

IPC: C07D455/04 ,  C07D221/18 ,  C07D471/00 ,  A61K31/44

CPC classification number: C07D471/04 ,  C07D491/04 ,  C07D493/04

Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.

公开(公告)号：US20020183314A1

公开(公告)日：2002-12-05

申请号：US10080503

申请日：2002-02-22

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Robert I. Higuchi ,  Lin Zhi ,  Donald S. Karanewsky ,  Anthony W. Thompson ,  Thomas R. Caferro ,  Neelakandha S. Mani ,  Jyun-Hung Chen ,  Marquis L. Cummings ,  James P. Edwards ,  Mark E. Adams ,  Charlotte L.F. Deckhut

IPC: C07D471/02 ,  C07D491/02 ,  C07D498/02

CPC classification number: C07D498/04 ,  C07D498/14 ,  Y02P20/582

Abstract: Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.

Abstract translation: 描述了新型非甾体三环喹啉酮和三环喹啉化合物以及作为雄激素受体（AR）的激动剂，部分激动剂和/或拮抗剂及其用途的组合物及其用途。

公开(公告)号：US6093826A

公开(公告)日：2000-07-25

申请号：US93421

申请日：1998-06-08

Applicant: James P. Edwards ,  Todd K. Jones

Inventor： James P. Edwards ,  Todd K. Jones

IPC: C07D491/04 ,  C07D471/00

CPC classification number: C07D491/04

Abstract: A method for preparing C(5)-substituted 1,2-dihydro-5H-chromeno[3,4-.function.]quinolines from a lactol precursor is provided. The method comprises converting the lactol to one of a select number of mixed acetal derivatives, and then treating the acetals with a Grignard reagent. The new process provides products in higher yield and greater purity. Novel intermediates of this method are also claimed.

Abstract translation: 提供了从乳糖前体制备C（5） - 取代的1,2-二氢-5H-色烯并[3,4-f]喹啉的方法。 该方法包括将乳糖转化为选定数量的混合缩醛衍生物之一，然后用格氏试剂处理该缩醛。 新工艺提供了更高产量和更高纯度的产品。 还要求保护该方法的新型中间体。

公开(公告)号：US6093825A

公开(公告)日：2000-07-25

申请号：US86004

申请日：1998-05-27

Applicant: Reinhold H. W. Bender ,  James P. Edwards ,  Todd K. Jones

Inventor： Reinhold H. W. Bender ,  James P. Edwards ,  Todd K. Jones

IPC: C07D491/04 ,  C07D471/00 ,  C07D491/00 ,  C07D498/00 ,  C07D513/00

CPC classification number: C07D491/04

Abstract: Methods for conversion of anilines to 1,2-dihydroquinolines. 1,2-dihydroquinoliiies are generated from combining an aniline, a silylating agent, and further condensing with a ketone in the presence of a catalyst. In one aspect, the silylation of the aniline may be performed in a one-step synthesis by adding the silylating, agent to the same reaction vessel as the ketone, aniline, and catalyst. In a second aspect, the 1,2-dihydroquinoline is generated in a two-step synthesis where an N-silyl aniline is formed prior to the addition of the ketone and catalyst.

Abstract translation: 将苯胺转化为1,2-二氢喹啉的方法。 1,2-二氢喹啉由苯胺，甲硅烷化剂组合，并在催化剂存在下与酮进一步缩合而产生。 一方面，苯胺的甲硅烷基化可以通过将甲硅烷基化试剂加入到与酮，苯胺和催化剂相同的反应容器中，在一步合成中进行。 在第二方面，1,2-二氢喹啉是在加入酮和催化剂之前形成N-甲硅烷基苯胺的两步合成中产生的。

公开(公告)号：US6017924A

公开(公告)日：2000-01-25

申请号：US373460

申请日：1999-08-12

Applicant: James P Edwards ,  Robert Higuchi ,  Todd K Jones ,  Lawrence G Hamann

Inventor： James P Edwards ,  Robert Higuchi ,  Todd K Jones ,  Lawrence G Hamann

IPC: C07D471/04 ,  C07D471/14 ,  C07D498/16 ,  A61K31/44

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Non-steroidal compounds that are high affinity, high selectivity modulators for androgen receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring androgen receptor agonist, partial agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the androgen receptor modulator compounds.

公开(公告)号：US5998654A

公开(公告)日：1999-12-07

申请号：US901014

申请日：1997-07-25

Applicant: Marcus F. Boehm ,  Lin Zhang

Inventor： Marcus F. Boehm ,  Lin Zhang

IPC: C07C57/42 ,  C07C59/64 ,  C07C229/00 ,  A01N37/10

CPC classification number: C07C59/64 ,  C07C57/42

Abstract: Trienoic compounds having activity as antagonists for retinoic acid receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their therapeutic use.

Abstract translation: 提供了具有视黄酸受体拮抗剂活性的三烯酸化合物。 还提供了掺入这些化合物的药物组合物及其治疗用途的方法。

公开(公告)号：US5688808A

公开(公告)日：1997-11-18

申请号：US463231

申请日：1995-06-05

Applicant: Todd K. Jones ,  David T. Winn ,  Lin Zhi ,  Lawrence G. Hamann ,  Christopher M. Tegley ,  Charlotte L. F. Pooley

Inventor： Todd K. Jones ,  David T. Winn ,  Lin Zhi ,  Lawrence G. Hamann ,  Christopher M. Tegley ,  Charlotte L. F. Pooley

IPC: C07D215/06 ,  C07D221/18 ,  C07D311/80 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/052 ,  A61K31/47 ,  C07D221/16 ,  C07D491/48 ,  C07D491/52

CPC classification number: C07D401/04 ,  C07D215/06 ,  C07D221/18 ,  C07D311/80 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/04

Abstract: Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

公开(公告)号：US20240294565A1

公开(公告)日：2024-09-05

申请号：US18561681

申请日：2022-05-10

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Lin Zhi

IPC: C07H19/10 ,  A61K31/44 ,  A61K31/7072 ,  C07H19/11

CPC classification number: C07H19/10 ,  A61K31/44 ,  A61K31/7072 ,  C07H19/11

Abstract: Provided herein am phosphoramidate and cyclophosphate prodrug compounds of unnatural configuration nucleotide, their preparation, and their uses, such as treating liver diseases or nonliver diseases via intervening in the molecular pathways in the liver.