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    LOW MELTING PROPIONIC ACID DERIVATIVE PARTICLES FOR USE IN ORAL DOSAGE FORMS
    12.
    发明申请
    LOW MELTING PROPIONIC ACID DERIVATIVE PARTICLES FOR USE IN ORAL DOSAGE FORMS 审中-公开
    用于口服剂型的低熔点丙酸衍生物颗粒

    公开(公告)号：US20140256810A1

    公开(公告)日：2014-09-11

    申请号：US13789797

    申请日：2013-03-08

    申请人： MCNEIL-PPC, INC.

    发明人： Saumitra Bagchi ,  Murali K. Vuppala

    IPC分类号： A61K9/00 ,  A61J3/06 ,  A61J3/02

    CPC分类号： A61K9/0056 ,  A61K9/0095 ,  A61K9/10 ,  A61K9/145 ,  A61K9/2018 ,  A61K31/192 ,  A61K47/14

    摘要： Low melting propionic acid derivative particles that are free flowing and have significantly reduced or eliminated throat burn are disclosed. A method of manufacturing the low melting propionic acid derivative particles; dosage forms containing the low melting propionic acid derivative particles; methods of manufacturing the dosage forms; and methods of treatment using the dosage forms are also disclosed.

    摘要翻译： 公开了自由流动并显着减少或消除喉灼伤的低熔点丙酸衍生物颗粒。 制备低熔点丙酸衍生物颗粒的方法; 含有低熔点丙酸衍生物颗粒的剂型; 制作剂型的方法; 还公开了使用剂型的治疗方法。

    Fluid Management Device with Fluid Transport Element for use within a Body
    16.
    发明申请
    Fluid Management Device with Fluid Transport Element for use within a Body 审中-公开
    具有流体输送元件的流体管理装置，用于体内

    公开(公告)号：US20140052090A1

    公开(公告)日：2014-02-20

    申请号：US14063147

    申请日：2013-10-25

    申请人： McNeil-PPC, Inc.

    发明人： David J. Chase ,  Erin Marsee ,  Tara Glasgow

    IPC分类号： A61F13/20

    CPC分类号： A61F13/2022 ,  A61F13/206 ,  A61F13/2065

    摘要： A fluid management device for use in a mammalian body has at least one fluid transport element capable of interfacing with a mammalian body element to provide a substantially uninterrupted fluid conduit. The fluid conduit provides a fluid path between at least one fluid transport element and the storage element. A distal portion of the at least one fluid transport element is capable of extending away from the fluid storage element.

    摘要翻译： 用于哺乳动物体内的流体管理装置具有能够与哺乳动物体元件接合以提供基本不间断流体导管的至少一个流体输送元件。 流体导管在至少一个流体输送元件和存储元件之间提供流体路径。 至少一个流体输送元件的远端部分能够远离流体存储元件延伸。

    METHOD OF MANUFACTURING SOLID DOSAGE FORM
    18.
    发明申请
    METHOD OF MANUFACTURING SOLID DOSAGE FORM 有权
    制造固体剂型的方法

    公开(公告)号：US20130292884A1

    公开(公告)日：2013-11-07

    申请号：US13804229

    申请日：2013-03-14

    申请人： MCNEIL-PPC, INC.

    发明人： Oliver Anderson ,  Harry S. Sowden ,  Gerard P. McNally ,  William J. Stuhl

    IPC分类号： A61J3/00

    CPC分类号： A61J3/10 ,  A61J3/00 ,  A61J3/06 ,  A61K9/2072 ,  A61K9/2086 ,  A61K9/2095 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4545 ,  A61K2300/00

    摘要： In one aspect, the present invention features a method of manufacturing a solid dosage form, the method including the steps of: (a) measuring an amount of a first powder blend within a dosing nozzle, wherein the first powder blend includes a pharmaceutically active agent; (b) discharging the measured amount of a first powder blend from the dosing nozzle into a forming cavity within a die block, the forming cavity having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (c) moving a first forming tool into the forming cavity through the first opening of the forming cavity such that the first powder blend is formed into the shape of the dosage form within the forming cavity between the inner wall, the first forming tool and a second forming tool within or adjacent to the cavity; (d) applying RF energy between a first electrode and a second electrode such that the energy heats the first powder blend within the forming cavity to form the dosage form; and (e) removing the dosage form from the forming cavity.

    摘要翻译： 一方面，本发明的特征在于制备固体剂型的方法，所述方法包括以下步骤：（a）测量剂量喷嘴内的第一粉末混合物的量，其中第一粉末混合物包含药物活性剂 ; （b）将测量量的第一粉末混合物从计量喷嘴排出到模具块内的成形腔中，所述成型腔具有内壁，在模块的一侧的表面处的第一开口，以及第二 在模块的相对侧的表面开口; （c）通过成形腔的第一开口将第一成形工具移动到成形腔中，使得第一粉末混合物在内壁，第一成形工具和第一成形工具之间的成形腔内形成为剂型的形状 第二成形工具在腔体内或邻近腔体; （d）在第一电极和第二电极之间施加RF能量，使得所述能量加热所述成形腔内的第一粉末混合物以形成所述剂型; 和（e）从形成腔去除剂型。