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公开(公告)号：US20230071014A1
公开(公告)日：2023-03-09
申请号：US17797048
申请日：2020-07-15
发明人： Wu Zhong , Zhihong Hu , Gengfu Xiao , Ruiyuan Cao , Manli Wang , Leike Zhang , Wei Li , Shiyong Fan , Song Li
IPC分类号： A61K31/427 , A61P31/14
摘要： A use of ritonavir, or a geometric isomer, pharmaceutically acceptable salt, solvate, and/or hydrate thereof, and a pharmaceutical composition containing the above compound in treating a SARS-CoV-2 infections.
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公开(公告)号：US20220380402A1
公开(公告)日：2022-12-01
申请号：US17621003
申请日：2020-06-22
发明人： Wu Zhong , Min Zhang , Xinbo Zhou , Shiyong Fan , Song Li
IPC分类号： C07H19/167
摘要： The present disclosure provides 6-hydrazinoadenosine represented by the general Formula (I) and its derivatives with A2A adenosine receptor agonist activity, and pharmaceutical compositions containing them. The compound and composition can be used as A2A adenosine receptor agonists and used as medicament.
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公开(公告)号：US20220363710A1
公开(公告)日：2022-11-17
申请号：US17621099
申请日：2020-06-22
发明人： Wu Zhong , Min Zhang , Xinbo Zhou , Shiyong Fan , Song Li
IPC分类号： C07H19/23
摘要： The present application provides a small-molecule compound, represented by general Formula (I), having A2A adenosine receptor antagonistic activity and a pharmaceutical composition containing same. The compound and composition can be used as A2A adenosine receptor antagonistic agents.
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公开(公告)号：US20220105077A1
公开(公告)日：2022-04-07
申请号：US17552609
申请日：2021-12-16
发明人： Wu ZHONG , Xinbo ZHOU , Ruiyuan CAO , Dian XIAO , Manli WANG , Shiyong FAN , Zhihong HU , Song LI
IPC分类号： A61K31/4196 , A61K31/13 , A61K31/522 , A61K31/506 , A61K31/7072 , A61K31/675 , A61K31/536 , A61K31/519 , A61K31/7056 , A61K38/21 , A61K38/16 , A61P31/16
摘要： Related is application of 2,4,5-trisubstituted 1,2,4-triazolones in antiviral therapy, particularly related to use of a compound of formula I in the preparation a medicament, wherein the medicament is used to prevent and/or treat a disease associated with a virus. It is shown in vitro experiment that, the compound effectively inhibits viral infections, and shows low toxicity in some tests,
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公开(公告)号：US20220090195A1
公开(公告)日：2022-03-24
申请号：US17419329
申请日：2019-03-12
发明人： Shengqi WANG , Qiqi LIU , Liyan LIU , Ying ZHANG , Yi ZHAO
IPC分类号： C12Q1/6876 , C12Q1/686 , C12Q1/6806
摘要： Disclosed by the present application are a structure of a double-stranded oligonucleotide nucleic acid probe, a method of use and applications thereof in nucleic acid fluorescence qualitative and quantitative analysis, medical diagnosis and life science researches. The double-stranded oligonucleotide nucleic acid probe is composed of two completely or partially base-complementary oligonucleotide strands; the end of each oligonucleotide strand may be connected to a fluorescent group or a corresponding fluorescent quenching group; and the two oligonucleotide probe strands may hybridize with a target nucleic acid sequence to be tested.
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公开(公告)号：US20220072538A1
公开(公告)日：2022-03-10
申请号：US17278243
申请日：2018-12-28
发明人： Shengqi WANG , Rui XIAO , Zhen RONG
摘要： The present application relates to the field of biochip detection apparatus, and in particular to a fully automated biochip workstation and a detection method using same. Biochip detection apparatus comprises a cavity for carrying a test tube vial, the test tube vial being used for accommodating a sample to be detected and a biochip, the cavity having a temperature control function; a liquid storage device for storing liquid; a pumping device for pumping the liquid in the liquid storage device to the test tube vial, the pumping device being in fluid communication with a separation needle for injecting a mixed liquid into the test tube vial; an imaging device for monitoring the chip state in the test tube vial; and a data processing device configured to acquire hybridization results on the basis of information about a biochip state acquired by the imaging device. The biochip workstation provided in the present application implements the integration of biochip reactions and the output of detection results, improves the processing efficiency of samples, saves manpower, and has more stable and reliable results.
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公开(公告)号：US11180463B2
公开(公告)日：2021-11-23
申请号：US16382539
申请日：2019-04-12
发明人： Song Li , Wu Zhong , Shuang Cao , Lili Wang , Zhibing Zheng , Junhai Xiao , Xinbo Zhou
IPC分类号： C07D277/22 , A61K31/426 , C07D277/30 , A61K8/49 , A61K31/4422 , A61Q11/00 , A61Q19/08
摘要： The present invention pertains to field of pharmaceutical chemicals, and relates to thiazole inner salt compounds, preparation methods and uses thereof. Specifically, the present invention relates to a compound of Formula I, hydrates or pharmaceutically acceptable salts thereof. The compound of Formula I of the present invention is a potent cross-linking protein cleavage agent, has a stable structure, good physical and chemical properties, and good pharmacological activities, and is suitable for large scale production to obtain samples with stable, controllable and reliable quality, thereby being suitable for pharmaceutical development.
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公开(公告)号：US11149253B2
公开(公告)日：2021-10-19
申请号：US16306646
申请日：2017-05-27
发明人： Yunfang Wang , Shuyong Wang , Wencheng Zhang , Jinhua Qin , Xuan Wang , Mingyang Chang , Fang Yan , Xuetao Pei
摘要： Provided are a small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, a reprogramming method and an application. Human gastric epithelial cells (hGECs) are used as initiating cells, human gastric subepithelial myofibroblasts (aGSEMFs) are used as a trophoblast, a compound combination having all or a plurality of FBP, Bay K 8644, Bix01294, SB431542 or A813-01, VPA, RG108, PD0325901 and PS48 including SB or A83 is used to reprogram digestive tract derived epithelial cells to endodermal stem/progenitor cells, and the endodermal stem/progenitor cells can be used for inducing differentiation towards liver cells, pancreatic beta cells and intestinal cells.
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19.发明授权公开(公告)号：US10709777B2
公开(公告)日：2020-07-14
申请号：US15532823
申请日：2015-09-07
发明人： Jun Wu , Peng Sun , Bo Liu , Shaohong Chang , Xin Gong , Hengliang Wang , Li Zhu , Chao Pan , Erling Feng
IPC分类号： A61K39/02 , A61K39/112 , C12N15/63 , A61K48/00 , C12N15/11 , C12N9/10 , C12N9/00 , C12N15/74 , A61K39/00
摘要： The present invention discloses a Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.
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公开(公告)号：US10314794B2
公开(公告)日：2019-06-11
申请号：US15320200
申请日：2015-06-23
发明人： Chunsheng Gao , Yuli Wang , Meiyan Yang , Li Shan , Jingjing Dai , Yong Qian , Yan Qiu
IPC分类号： A61K31/138 , A61K9/48 , A61K9/50 , A61K31/549 , A61K9/16
摘要： The invention relates to a drug sustained-release composition, particularly a sustained-release composition comprising metoprolol and preparation method thereof. The invention also relates to a combination product comprising a sustained-release composition comprising metoprolol and a pharmaceutical composition comprising hydrochlorothiazide. The sustained-release composition comprising metoprolol according to the invention eliminates the phenomena of delayed release of such sustained-release compositions in the prior art, has a better drug release curve, and also have the advantages such as simple formula, easy operation, stable quality, strong controllability, and good reproducibility, and therefore have good application prospects.
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