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公开(公告)号：US20120318017A1
公开(公告)日：2012-12-20
申请号：US13526614
申请日：2012-06-19
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
IPC: F25J1/02
CPC classification number: B01D7/00 , B01D5/0006 , B01D8/00 , B01D53/265 , B01D2256/10 , F25B39/04 , F28D7/0066 , F28D7/024
Abstract: A method and apparatus for condensing vapor in a gas. A cryogen, such as liquid nitrogen, may be provided into first and second coil sets in a condenser housing to cool the condensable vapor in the housing to condense the vapor into a liquid or solid form. The flow of cryogen in the first and second coil sets may be independently controlled, coils in the first and/or second coil sets may have a substantially equal length, and/or coils in the first and/or second coil sets may have uppermost portions that are located at a substantially equal height.
Abstract translation: 一种用于冷凝气体中的蒸气的方法和装置。 诸如液氮的冷冻剂可以设置在冷凝器壳体中的第一和第二线圈组中，以冷却壳体中的可冷凝蒸气以将蒸气冷凝成液体或固体形式。 可以独立地控制第一和第二线圈组中的冷冻剂的流动，第一和/或第二线圈组中的线圈可以具有基本相等的长度，和/或第一和/或第二线圈组中的线圈可以具有最高部分 它们位于基本上相等的高度。
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12.发明申请SYSTEMS AND METHODS FOR PRODUCING A GAS DISPERSION IN A BIOLOGICAL SUBSTANCE IN A DISPOSABLE VESSEL 审中-公开生产废水中生物物质气体分布的系统和方法公开(公告)号：US20120295333A1
公开(公告)日：2012-11-22
申请号：US13475239
申请日：2012-05-18
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
Abstract: Biological liquid substances in a disposable bioreactor or a disposable fermentor is enriched with a dissolved gas such as oxygen. The gas is provided to the liquid in meeting growth needs of biomass within the disposable vessel. The liquid is processed through a bubble forming element such as a supersonic mixer, a membrane sparger, or the like, to form a gas-liquid dispersion. The dispersion has a high interfacial surface area for facilitating gas dissolution in the liquid. Receptacles of the disposable vessel may be coupled (e.g., magnetically) to one or more processing devices (e.g., motors, pumps, gas sources) outside of the disposable vessel so that components within the disposable vessel are able to perform functions suitable for furthering reaction and/or fermentation processes.
Abstract translation: 一次性生物反应器或一次性发酵罐中的生物液体物质富含溶解气体如氧气。 将气体提供给液体以满足一次性容器内生物质的生长需求。 液体通过诸如超声波混合器，隔膜喷雾器等的气泡形成元件加工以形成气液分散体。 分散体具有高的界面表面积，以便于气体溶解在液体中。 一次性容器的容器可以与一次性容器外部的一个或多个处理装置（例如，马达，泵，气体源）耦合（例如，磁性），使得一次性容器内的部件能够执行适于进一步反应的功能 和/或发酵过程。
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公开(公告)号：US20120295332A1
公开(公告)日：2012-11-22
申请号：US13475163
申请日：2012-05-18
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
Abstract: Oxygen is delivered into a liquid contained within a vessel. Oxygen-rich gas is introduced at an inner mixing region of a vessel toward an agitating element for dissolving some of the oxygen into the liquid. Air is introduced to the liquid at a location different from where the oxygen-rich gas is introduced, minimizing coalescing of bubbles of the oxygen-rich gas and air bubbles. Running the agitating element in the vessel may induce mixing of the liquid and improve oxygen dissolution. Movement of the air bubbles can also generate a mixing effect on the liquid, yet independent from mixing caused by the agitating element. In some embodiments, currents produced by the agitating element are asymmetric with respect to a vertical axis of the vessel. Air bubbles may also form an asymmetric configuration of bubbles about the vertical axis.
Abstract translation: 氧被输送到容纳在容器内的液体中。 在容器的内部混合区域将富氧气体引入用于将一些氧气溶解到液体中的搅拌元件。 在与富氧气体的引导位置不同的位置处将空气引入到液体中，使富氧气体和气泡的气泡的聚结最小化。 在容器中运行搅拌元件可能引起液体混合并改善氧气溶解。 气泡的移动也可以对液体产生混合效果，而与搅拌元件引起的混合无关。 在一些实施例中，由搅拌元件产生的电流相对于容器的垂直轴线是不对称的。 气泡也可以围绕垂直轴形成气泡的非对称构型。
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公开(公告)号：US20120102977A1
公开(公告)日：2012-05-03
申请号：US13097763
申请日：2011-04-29
Applicant: Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
Inventor： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
IPC: F17C5/02
CPC classification number: A01N1/0257 , A01N1/0284 , A01N1/0289 , F25D3/102 , F25D29/001
Abstract: A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
Abstract translation: 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。
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公开(公告)号：US5362455A
公开(公告)日：1994-11-08
申请号：US11064
申请日：1993-01-29
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
CPC classification number: B01J19/26 , B01D9/0009 , B01J8/226 , Y10T117/10 , Y10T117/1024 , Y10T117/1096
Abstract: A direct contact cryogenic crystallizer having a vertically oriented draft tube into which cryogenic fluid is injected at a high velocity along with warm gas and through which a crystal slurry is drawn for subsequent cooling and agitation for the production of crystals.
Abstract translation: 一种直接接触式低温结晶器，其具有垂直定向的导流管，低温流体与暖气一起以高速注入其中，并通过该低温液体引入晶体浆液用于随后的冷却和搅拌以产生晶体。
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Patent Agency Ranking
公开(公告)号：US4931225A
公开(公告)日：1990-06-05
申请号：US317577
申请日：1989-03-01
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
CPC classification number: B01D19/0005 , B01F5/045 , B01J10/002 , B01J19/26 , C02F1/20 , B01F3/04099 , B01J2219/00162 , B01J2219/00164 , Y10S261/75 , Y10S261/78
Abstract: The present invention relates to an improved method and apparatus for dispersing a gas into a liquid. Gas is injected into a liquid and the flowing gas-liquid mixture is accelerated by a flow area contraction to at least sonic flow velocity, and subsequently decelerated by a flow area expansion to subsonic velocity. The attendant shock waves disperse the gas in the liquid. Preferred embodiments include off-centering the gas injection direction from the centerline of the contracting flow area and controlling the pressure at the exit of the expanding flow area.
Abstract translation: 本发明涉及一种用于将气体分散到液体中的改进方法和装置。 将气体注入液体中，流动的气液混合物通过流动面积收缩加速至至少声流速度，随后通过流动面积膨胀减速至亚音速。 伴随的冲击波将气体分散在液体中。 优选实施例包括从收缩流动区域的中心线偏离气体注入方向并控制膨胀流动区域出口处的压力。
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公开(公告)号：US20180050312A1
公开(公告)日：2018-02-22
申请号：US15678465
申请日：2017-08-16
Applicant: Alan T Cheng , Yeu-Chuan Simon Ho , Balazs Hunek
Inventor： Alan T Cheng , Yeu-Chuan Simon Ho , Balazs Hunek
CPC classification number: B01F3/04262 , A01K61/10 , A01K63/042 , B01F3/04099 , B01F3/04985 , B01F5/0476 , B01F13/1022 , B01F2003/04319 , B01F2003/0439 , B01F2003/04879 , B01F2003/049 , B01F2215/0052
Abstract: Disclosed are a system and a method for dissolving water-soluble gas such as oxygen into water, employing microporous membrane.
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18.发明申请公开(公告)号：US20120295248A1
公开(公告)日：2012-11-22
申请号：US13475294
申请日：2012-05-18
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
CPC classification number: C12M27/02 , B01F3/04609 , B01F7/0065 , B01F15/00175 , B01F15/0022 , B01F15/00344 , B01F15/00389 , B01F15/0085 , C12M29/24
Abstract: A disposable mixing vessel incorporates a system for dynamic gas control. The disposable mixing vessel includes a first agitating element and a second agitating element located above the first agitating element. The system for dynamic gas control enables a cell culture process to occur in the disposable mixing vessel while maintaining certain parameters of the liquid medium to be within a desired range. Such parameters may include the level of dissolved carbon dioxide, the level of dissolved oxygen, the pH and the osmolality. The system for dynamic gas control may control gas inlet and outlet ports in the disposable mixing vessel for sweeping a suitable composition of gas across the headspace of the liquid medium.
Abstract translation: 一次性混合容器包括用于动态气体控制的系统。 一次性混合容器包括位于第一搅拌元件上方的第一搅拌元件和第二搅拌元件。 用于动态气体控制的系统使得能够在一次性混合容器中发生细胞培养过程，同时保持液体介质的某些参数在期望的范围内。 这些参数可以包括溶解的二氧化碳的水平，溶解氧的水平，pH和重量摩尔渗透压浓度。 用于动态气体控制的系统可以控制一次性混合容器中的气体入口和出口，用于在液体介质的顶部空间上扫过合适的气体组成。
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公开(公告)号：US5211916A
公开(公告)日：1993-05-18
申请号：US813022
申请日：1991-12-24
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
CPC classification number: B01D19/0005 , Y10S261/56 , Y10S261/78
Abstract: An in-line stripper has a venturi-conical mixer combination in which the annular space thereby is automatically adjustable in response to changes in viscosity or other property conditions.
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公开(公告)号：US5098267A
公开(公告)日：1992-03-24
申请号：US542062
申请日：1990-06-22
Applicant: Alan T. Cheng
Inventor： Alan T. Cheng
CPC classification number: B29C44/3449 , B29B7/7414 , B29C44/3446 , B29C44/422 , B29C47/6006 , B29C47/0009
Abstract: A single-state apparatus for injection molding structural foam articles has a resin plasticating barrel in which a cylindrical plunger reciprocates and rotates. The plunger has a screw section for plasticating resin and advancing the plasticate into a metering section with grooves in which plasticate flows. The grooves are contiguous to a fluid foaming agent inlet in the side of the barrel so that they alternately open and close the inlet to introduce fluid foaming agent periodically into the plasticate. Downstream, the plunger has channels for mixing and advancing plasticate to the forward end of the plunger where it accumulates and is periodically rammed by the plunger into the mold.
Abstract translation: 用于注塑结构泡沫制品的单态装置具有树脂塑化筒，其中圆柱形柱塞往复运动并旋转。 柱塞具有用于塑化树脂的螺旋部分，并且使塑性物质进入具有塑化物流动的凹槽的计量部分。 槽与筒体侧面的流体发泡剂入口邻接，使得它们交替地打开和关闭入口，以将流体发泡剂周期性地引入塑性物质中。 在下游，柱塞具有用于混合和推进塑性物质到柱塞前端的通道，其中它积聚并且被柱塞周期性地压入模具中。
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