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11.发明授权Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives 失效用于预防由透明质酸衍生物组成的手术后粘连的生物材料公开(公告)号：US06723709B1
公开(公告)日：2004-04-20
申请号：US09031835
申请日：1998-02-27
IPC分类号： A61K31728
CPC分类号： A61L31/10 , A61L31/042 , A61L31/129 , C08L5/08
摘要： New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesion.
摘要翻译： 新的生物材料基本上由透明质酸的酯化衍生物或透明质酸的交联衍生物构成，用于手术部门，特别是用于预防手术后粘连。
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12.发明申请Use of hyaluronic acid polymers for mucosal delivery of vaccine and adjuvants 审中-公开使用透明质酸聚合物进行疫苗和佐剂的粘膜递送公开(公告)号：US20050226937A1
公开(公告)日：2005-10-13
申请号：US11001563
申请日：2004-11-30
申请人： Derek O'Hagan , Alessandra Pavesio
发明人： Derek O'Hagan , Alessandra Pavesio
CPC分类号： A61K47/36 , A61K9/0043 , A61K9/1652 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/543 , A61K2039/55544 , A61K2039/55555 , C12N2760/16134
摘要： Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same.
摘要翻译： 提供了组合物，其包括与疫苗抗原组合的透明质酸衍生物和用于粘膜递送的任选的佐剂。 还提供了制备组合物的方法以及使用其的免疫方法。
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13.发明授权公开(公告)号：US06872819B1
公开(公告)日：2005-03-29
申请号：US09700142
申请日：1998-05-27
IPC分类号： A61L27/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61L24/00 , A61L24/08 , A61L27/20 , A61L27/56 , D04H1/42 , D04H1/4266 , C08B37/00
CPC分类号： D04H1/4266 , A61F2/28 , A61F2/30756 , A61F2002/30199 , A61F2230/0063 , A61L24/0036 , A61L24/08 , A61L27/20 , A61L27/56 , D04H1/4382 , Y10T428/298 , Y10T428/31544 , C08L5/08
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的无纺织物材料。 无纺布材料由嵌入基质中的线组成，其中基质和线可以由透明质酸的酯单独或组合使用，或透明质酸的酯与海藻酸的酯或 其他聚合物。
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14.发明申请Biomaterials based on hyaluronic acid for the anti-angiogenic therapy in the treatment of tumors 有权基于透明质酸的生物材料用于治疗肿瘤的抗血管生成治疗公开(公告)号：US20050037049A1
公开(公告)日：2005-02-17
申请号：US10501030
申请日：2003-01-07
IPC分类号： A61K38/17 , A61K31/282 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/715 , A61K31/717 , A61K31/722 , A61K31/728 , A61K31/729 , A61K31/732 , A61K31/734 , A61K31/765 , A61K31/785 , A61K31/795 , A61L31/04 , A61P9/00 , A61P35/00
CPC分类号： A61L31/042 , C08L5/08
摘要： The use in the medical-surgical field of biomaterials based on hyaluronic acid derivatives, optionally in association with natural, synthetic or semisynthetic biopolymers, for suppressing the angiogenic process associated with tumour proliferation (in primary and secondary tumours) is disclosed.
摘要翻译： 公开了用于抑制与肿瘤增殖相关的血管生成过程（在原发性和继发性肿瘤中）的基于透明质酸衍生物的生物材料的医学外科领域，任选与天然的，合成的或半合成的生物聚合物结合。
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公开(公告)号：US06699471B2
公开(公告)日：2004-03-02
申请号：US09887757
申请日：2001-06-21
IPC分类号： C12N500
CPC分类号： A61L27/3817 , A61L27/20 , A61L27/3839 , A61L27/3852 , A61L2400/06 , C08L5/08
摘要： Disclosed is an injectable, biocompatible and biodegradable composition, comprising at least one hyaluronic acid benzyl ester or auto-cross-linked derivative, in combination with at least one mammalian cell and/or at least one pharmacologically or biologically active substance and/or micro-particles such as fibres, granules, microspheres or sponge fragments of a hyaluronic acid derivative.
摘要翻译： 公开了一种可注射的，生物相容的和可生物降解的组合物，其包含至少一种透明质酸苄酯或自交联衍生物与至少一种哺乳动物细胞和/或至少一种药理学或生物活性物质和/ 颗粒如透明质酸衍生物的纤维，颗粒，微球或海绵片。
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16.发明申请Biomaterials In the Form of Fibres for Use as Medical Devices In the Treatment of Wounds, and Their Production Process 审中-公开用于医疗器械的纤维形式的生物材料在伤口的治疗及其生产过程中公开(公告)号：US20100144666A1
公开(公告)日：2010-06-10
申请号：US11988344
申请日：2006-06-22
IPC分类号： A61K31/728 , A61P17/02
CPC分类号： A61L15/225 , C08L5/08
摘要： The present invention relates to new biomaterials in the form of fibres, essentially consisting of a mixture of gellan and hyaluronic acid derivatives, for use in surgery, especially in the treatment of wounds and mild burns. The present invention also relates to the process for the preparation of said biomaterials.
摘要翻译： 本发明涉及纤维形式的新型生物材料，其基本上由结晶和透明质酸衍生物的混合物组成，用于手术，特别是治疗伤口和轻度烧伤。 本发明还涉及制备所述生物材料的方法。
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17.发明申请Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants 有权使用透明质酸聚合物用于粘膜递送疫苗抗原和佐剂公开(公告)号：US20100080823A1
公开(公告)日：2010-04-01
申请号：US12590548
申请日：2009-11-10
申请人： Derek O'Hagan , Alessandra Pavesio
发明人： Derek O'Hagan , Alessandra Pavesio
IPC分类号： A61K39/145 , A61K39/02
CPC分类号： A61K47/36 , A61K9/0043 , A61K9/1652 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/543 , A61K2039/55544 , A61K2039/55555 , C12N2760/16134
摘要： Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same.
摘要翻译： 提供了组合物，其包括与疫苗抗原组合的透明质酸衍生物和用于粘膜递送的任选的佐剂。 还提供了制备组合物的方法以及使用其的免疫方法。
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18.发明授权Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins 失效用于输送成骨蛋白质的透明质酸衍生物的可注射载体制剂公开(公告)号：US07608580B2
公开(公告)日：2009-10-27
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/16
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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19.发明申请Biomaterials Based On Carboxymethylcellulose Salified With Zinc Associated With Hyaluronic Acid Derivatives 审中-公开基于与透明质酸衍生物相关的锌盐化的羧甲基纤维素的生物材料公开(公告)号：US20090233509A1
公开(公告)日：2009-09-17
申请号：US11989224
申请日：2006-07-17
CPC分类号： A61L15/46 , A61L15/225 , A61L2300/102 , A61L2300/208 , A61L2300/236 , A61L2300/45 , Y10T428/2976 , Y10T442/56 , C08L5/08
摘要： Biomaterials in the form of non-woven felts, comprising carboxymethylcellulose salified with zinc associated with hyaluronic derivatives at varying percentages, for use in surgery to treat various kinds of wounds, pressure sores, burns, and in all conditions requiring the association of a wound healing and protective action with an antibacterial and/or antifungal action.
摘要翻译： 以无纺布毡形式的生物材料，包括用不同百分比的与透明质酸衍生物相关的锌盐化的羧甲基纤维素，用于手术治疗各种伤口，压疮，烧伤以及需要伤口愈合的所有条件 并具有抗菌和/或抗真菌作用的保护作用。
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20.发明申请INJECTABLE CARRIER FORMULATIONS OF HYALURONIC ACID DERIVATIVES FOR DELIVERY OF OSTEOGENIC PROTEINS 失效用于递送蛋白质的羟丙酸衍生物的可手动载体配方公开(公告)号：US20070134342A1
公开(公告)日：2007-06-14
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/18 , A61K31/728 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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