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1.发明授权Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives 失效用于防止由透明质酸衍生物组成的手术后粘连的生物材料公开(公告)号：US07504386B2
公开(公告)日：2009-03-17
申请号：US10812587
申请日：2004-03-29
IPC分类号： A61K9/70 , A61K31/728
CPC分类号： A61L31/10 , A61L31/042 , A61L31/129 , C08L5/08
摘要： New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesions.
摘要翻译： 新的生物材料基本上由透明质酸的酯化衍生物或透明质酸的交联衍生物构成，用于手术部门，特别是用于预防手术后粘连。
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2.发明授权Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives 失效用于预防由透明质酸衍生物组成的手术后粘连的生物材料公开(公告)号：US06723709B1
公开(公告)日：2004-04-20
申请号：US09031835
申请日：1998-02-27
IPC分类号： A61K31728
CPC分类号： A61L31/10 , A61L31/042 , A61L31/129 , C08L5/08
摘要： New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesion.
摘要翻译： 新的生物材料基本上由透明质酸的酯化衍生物或透明质酸的交联衍生物构成，用于手术部门，特别是用于预防手术后粘连。
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公开(公告)号：US07968111B2
公开(公告)日：2011-06-28
申请号：US10467142
申请日：2002-02-06
IPC分类号： A61F2/00
CPC分类号： A61L27/3817 , A61L27/12 , A61L27/20 , A61L27/3852 , A61L27/3895 , A61L27/425 , A61L27/46 , C08L5/08
摘要： The invention concerns the preparation and use of a biocompatible, biocomponent material constituted by: (a) a three-dimensional matrix of hyaluronic acid derivatives witle a structure containing empty spaces; (b) a porous, three-dimensional matrix constituted by a ceramic material; (c) possibly containing pharmacologically or biologically active ingredients.
摘要翻译： 本发明涉及生物相容的生物组分材料的制备和使用，其由以下组成：（a）具有包含空白空间的结构的透明质酸衍生物的三维基质; （b）由陶瓷材料构成的多孔三维基体; （c）可能含有药理学或生物活性成分。
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4.发明授权Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins 失效用于输送成骨蛋白质的透明质酸衍生物的可注射载体制剂公开(公告)号：US07608580B2
公开(公告)日：2009-10-27
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/16
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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5.发明申请INJECTABLE CARRIER FORMULATIONS OF HYALURONIC ACID DERIVATIVES FOR DELIVERY OF OSTEOGENIC PROTEINS 失效用于递送蛋白质的羟丙酸衍生物的可手动载体配方公开(公告)号：US20070134342A1
公开(公告)日：2007-06-14
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/18 , A61K31/728 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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6.发明授权Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins 失效用于输送成骨蛋白质的透明质酸衍生物的可注射载体制剂公开(公告)号：US07189392B1
公开(公告)日：2007-03-13
申请号：US09687281
申请日：2000-10-13
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/43
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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7.发明授权公开(公告)号：US06872819B1
公开(公告)日：2005-03-29
申请号：US09700142
申请日：1998-05-27
IPC分类号： A61L27/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61L24/00 , A61L24/08 , A61L27/20 , A61L27/56 , D04H1/42 , D04H1/4266 , C08B37/00
CPC分类号： D04H1/4266 , A61F2/28 , A61F2/30756 , A61F2002/30199 , A61F2230/0063 , A61L24/0036 , A61L24/08 , A61L27/20 , A61L27/56 , D04H1/4382 , Y10T428/298 , Y10T428/31544 , C08L5/08
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的无纺织物材料。 无纺布材料由嵌入基质中的线组成，其中基质和线可以由透明质酸的酯单独或组合使用，或透明质酸的酯与海藻酸的酯或 其他聚合物。
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公开(公告)号：US06699471B2
公开(公告)日：2004-03-02
申请号：US09887757
申请日：2001-06-21
IPC分类号： C12N500
CPC分类号： A61L27/3817 , A61L27/20 , A61L27/3839 , A61L27/3852 , A61L2400/06 , C08L5/08
摘要： Disclosed is an injectable, biocompatible and biodegradable composition, comprising at least one hyaluronic acid benzyl ester or auto-cross-linked derivative, in combination with at least one mammalian cell and/or at least one pharmacologically or biologically active substance and/or micro-particles such as fibres, granules, microspheres or sponge fragments of a hyaluronic acid derivative.
摘要翻译： 公开了一种可注射的，生物相容的和可生物降解的组合物，其包含至少一种透明质酸苄酯或自交联衍生物与至少一种哺乳动物细胞和/或至少一种药理学或生物活性物质和/ 颗粒如透明质酸衍生物的纤维，颗粒，微球或海绵片。
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9.发明授权Biomaterials, their preparation by electrospinning and their use in the biomedical and surgical field 有权生物材料，它们通过静电纺丝制备及其在生物医学和外科领域的应用公开(公告)号：US08865964B2
公开(公告)日：2014-10-21
申请号：US13056541
申请日：2009-07-24
CPC分类号： A61L27/60 , Y10T442/3065 , Y10T442/614 , Y10T442/626
摘要： There is described a new non-woven fabric produced with the electrospinning technique, and the use thereof as new biomaterial for the biomedical and surgical field.
摘要翻译： 描述了一种用静电纺丝技术生产的新型无纺织物，并将其用作生物医学和外科领域的新生物材料。
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10.发明授权公开(公告)号：US08147811B1
公开(公告)日：2012-04-03
申请号：US10019387
申请日：2000-06-29
IPC分类号： A61K8/18
CPC分类号： A61K31/728 , A61K31/715 , A61L15/28 , A61L15/44 , A61L17/005 , A61L17/10 , A61L31/042 , A61L31/16 , A61L2300/00 , A61L2300/236 , A61L2300/404 , A61L2300/414 , A61L2300/45 , A61K31/00 , A61K2300/00 , C08L5/08
摘要： Use of hyaluronic acid derivatives for the preparation of biomaterials for the prevention of the formation and the treatment of cutaneous scars, wherein the hyaluronic acid derivatives are optionally combined with pharmacologically or biologically active compounds.
摘要翻译： 透明质酸衍生物用于制备用于预防皮肤瘢痕形成和治疗的生物材料的透明质酸衍生物，其中任选地与药理学或生物活性化合物组合。
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