公开(公告)号：US5556895A

公开(公告)日：1996-09-17

申请号：US455990

申请日：1995-05-31

Applicant: Edward S. Lipinsky ,  Richard G. Sinclair ,  James D. Browning ,  Alex Cheung ,  Kevin H. Schilling ,  Dan W. Verser

Inventor： Edward S. Lipinsky ,  Richard G. Sinclair ,  James D. Browning ,  Alex Cheung ,  Kevin H. Schilling ,  Dan W. Verser

IPC: A61L15/26 ,  A61L15/62 ,  C07D319/12 ,  C08G63/06 ,  C08G63/08 ,  C08G63/664 ,  C08G69/44 ,  C08J5/18 ,  C08K3/00 ,  C08K5/00 ,  C08K5/101 ,  C08L53/00 ,  C08L57/00 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C09D167/00 ,  C09D167/04 ,  C09D177/00 ,  C09D177/12 ,  C09J167/00 ,  C09J167/04 ,  C09J177/00 ,  C09J177/12 ,  D21H17/53 ,  C08J9/00

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L15/62 ,  C07D319/12 ,  C08G63/664 ,  C08G69/44 ,  C08K3/0025 ,  C08K5/0033 ,  C08K5/101 ,  C08L101/00 ,  C08L53/00 ,  C08L57/00 ,  C08L67/00 ,  C08L67/04 ,  C09D167/04 ,  C09J167/04 ,  D21H17/53 ,  B01J2219/1942 ,  C08G2230/00 ,  C08J2367/04 ,  Y10S521/916

Abstract: Disclosed are degradable materials including molded products, laminates, foams, nonwoven materials, adhesives, coatings and films, and particularly packaging films. The materials are made using polydioxaneone polymers comprising at least two different dioxaneone-based repeating units. Preferred polymers are polydioxanediones. First repeating units have less carbon atoms in constituent groups extending from the polymer backbone than second repeating units. Physical characteristics and degradation of the materials can be varied by varying the choice and/or relative proportions of first and second repeating units in the poldioxaneone polymers. Methods for preparing polydioxaneone polymers that can be used in the manufacture of the materials are also discussed, as are suitable monomers and methods for preparing such monomers.

Abstract translation: 公开了可降解材料，包括模制产品，层压材料，泡沫，非织造材料，粘合剂，涂料和薄膜，特别是包装薄膜。 所述材料是使用包含至少两种不同的腙类重复单元的聚二恶烷酮聚合物制成的。 优选的聚合物是聚二氧杂乙二酮。 第一重复单元在比聚合物主链延伸的组成基团中的碳原子少于第二重复单元。 材料的物理特性和降解可以通过改变聚二恶烷酮聚合物中第一和第二重复单元的选择和/或相对比例来改变。 还可以讨论制备可用于制备材料的聚二恶烷酮聚合物的方法，以及合适的单体和制备这种单体的方法。

公开(公告)号：US5445952A

公开(公告)日：1995-08-29

申请号：US7559

申请日：1993-01-22

Applicant: John W. Campbell ,  Alex Cheung ,  Christina K. Eddy

Inventor： John W. Campbell ,  Alex Cheung ,  Christina K. Eddy

IPC: C12N15/52 ,  C12N15/70 ,  C12P17/18 ,  C12P17/10 ,  C07H19/00 ,  C12N1/20 ,  C12P21/06

CPC classification number: C12P17/186 ,  C12N15/52 ,  C12N15/70

Abstract: The present invention relates to a method to enhance a cell's ability to produce biotin precursors and/or biotin by deregulating at least one enzyme of the fatty acid biosynthetic pathway in the cell, preferably an enzyme that carries out an early step in the pathway. Preferably, the biotin biosynthetic pathway is also deregulated. The invention includes biotin-producing cells in which at least one enzyme of the fatty acid biosynthetic pathway is deregulated, preferably by transforming the cells with nucleic acid sequences encoding at least one of those enzymes; methods to produce such cells; and use of such cells to produce biotin.

Abstract translation: 本发明涉及一种增强细胞生产生物素前体和/或生物素的能力的方法，该方法是通过使细胞中的至少一种脂肪酸生物合成途径的酶失调，优选在该途径中进行早期步骤的酶。 优选地，生物素生物合成途径也是失调的。 本发明包括生物素产生细胞，其中至少一种脂肪酸生物合成途径的酶被去调节，优选通过用编码这些酶中的至少一种的核酸序列转化细胞; 生产这种细胞的方法; 并使用这样的细胞产生生物素。

公开(公告)号：US5420304A

公开(公告)日：1995-05-30

申请号：US128797

申请日：1993-09-29

Applicant: Dan W. Verser ,  Alex Cheung ,  Timothy J. Eggeman ,  William A. Evanko ,  Kevin H. Schilling ,  Manfred Meiser ,  Anthony E. Allen ,  Melville E. D. Hillman ,  George E. Cremeans ,  Edward S. Lipinsky

Inventor： Dan W. Verser ,  Alex Cheung ,  Timothy J. Eggeman ,  William A. Evanko ,  Kevin H. Schilling ,  Manfred Meiser ,  Anthony E. Allen ,  Melville E. D. Hillman ,  George E. Cremeans ,  Edward S. Lipinsky

IPC: C07C51/48 ,  C07D319/12 ,  C08J5/18 ,  C08L67/04 ,  C09D167/04 ,  C07D319/00

CPC classification number: C07D319/12 ,  C07C51/48 ,  C08J5/18 ,  C08L67/04 ,  C09D167/04 ,  B01J2219/1942 ,  C08J2367/04 ,  Y02P20/125

Abstract: Disclosed is a novel integrated process for production of cyclic esters which includes recovery of starting materials, such as lactic acid from a dilute aqueous lactic acid-containing solution, by solvent extraction. The starting materials are then formed into cyclic esters by removal of water wherein the concentration of higher molecular weight oligomers is maintained below about 20 wt % of the reaction composition. The process further includes providing a recovery solvent for the reaction composition and separating the cyclic esters from the starting materials and higher molecular weight oligomers by liquid-liquid equilibrium separation. The present invention is further directed toward independent novel unit operations of the overall process. The present invention provides for the efficient production and recovery of cyclic esters due to integration of the various unit operations by use of appropriate solvents and recycle streams. In addition, high rates of conversion of starting materials and high rates of selective production of cyclic esters are achieved by appropriate control of process parameters.

Abstract translation: 公开了一种用于生产环酯的新型整合方法，其包括通过溶剂萃取从稀酸含水乳液中回收原料如乳酸。 然后将原料通过除去水形成环状酯，其中高分子量低聚物的浓度保持在反应组合物的约20重量％以下。 该方法还包括提供反应组合物的回收溶剂，并通过液 - 液平衡分离从起始原料和较高分子量的低聚物中分离环酯。 本发明进一步针对整个过程的独立的新颖的单元操作。 本发明提供了通过使用合适的溶剂和循环流将各种单元操作整合在一起的环酯的有效生产和回收。 此外，起始材料的高转化率和选择性生产环酯的高速率通过适当控制工艺参数来实现。