公开(公告)号：US4994263A

公开(公告)日：1991-02-19

申请号：US517520

申请日：1990-04-30

Applicant: Gerard Lang ,  Andre Deflandre ,  Irena Beck

Inventor： Gerard Lang ,  Andre Deflandre ,  Irena Beck

IPC: A61K31/365

CPC classification number: A61K31/365 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/864 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/944 ,  Y10S514/945 ,  Y10S514/96 ,  Y10S514/969

Abstract: A composition for treatment and treatment of certain skin diseases is disclosed. The treatment combines furocoumarins, UV-A radiation, and a benzylidene-camphor derivative. The composition and treatment produces the desirable results of the furocoumarin/UV-A radiation treatment without the undesirable phototoxic side effects.

Abstract translation: 公开了一种用于治疗和治疗某些皮肤疾病的组合物。 该治疗结合了呋喃香豆素，UV-A辐射和亚苄基 - 樟脑衍生物。 组合物和处理产生不需要光毒性副作用的呋喃香豆素/ UV-A辐射处理的期望结果。

公开(公告)号：US5587150A

公开(公告)日：1996-12-24

申请号：US461842

申请日：1995-06-05

Applicant: Andre Deflandre ,  Michel Dubois ,  Serge Forestier ,  Herve Richard

Inventor： Andre Deflandre ,  Michel Dubois ,  Serge Forestier ,  Herve Richard

IPC: A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K31/12 ,  A61K31/19 ,  A61Q17/04 ,  A61K7/42 ,  A61K7/40

CPC classification number: A61Q17/04 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K2800/52

Abstract: A photostable cosmetic screening composition and process for protection of the human epidermis against UV rays of wavelengths between 280 and 380 nm, the composition having, in a cosmetically acceptable vehicle containing at least one fatty phase, 1 to 5% by weight of a dibenzoylmethane derivative and at least 1% by weight of an alkyl .beta.-.beta.-diphenylacrylate or .alpha.-cyano-.beta.-.beta.-diphenylacrylate of formula (I), the mole ratio of the compound of formula (I) to the dibenzoylmethane derivative being not less than 0.8.

公开(公告)号：US5538716A

公开(公告)日：1996-07-23

申请号：US039047

申请日：1993-04-07

Applicant: Serge Forestier ,  Andre Deflandre

Inventor： Serge Forestier ,  Andre Deflandre

IPC: A61K8/35 ,  A61K8/40 ,  A61Q17/04 ,  C07C255/02 ,  A61K7/42

CPC classification number: A61K8/35 ,  A61K8/40 ,  A61Q17/04 ,  A61K2800/52

Abstract: A photostable cosmetic composition for protecting the human epidermis against UV radiation comprises, in a cosmetically acceptable carrier, from 0.5 to 5% by weight of 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane and at least 0.5% by weight of a compound of formula (I): ##STR1## where R stands for an alkyl radical, the molar ratio of the compound of formula (I) to 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane being 0.8 or over.

Abstract translation: PCT No.PCT / FR92 / 00774 Sec。 371日期：1993年4月7日 102（e）日期1993年4月7日PCT提交1992年8月5日PCT公布。 出版物WO93 / 02659 日期：1993年2月18日用于保护人类表皮免受紫外线辐射的光稳定化妆品组合物在化妆品上可接受的载体中包含0.5至5重量％的4-（1,1-二甲基乙基）-4'-甲氧基二苯甲酰甲烷，至少 0.5重量％的式（I）化合物：其中R代表烷基，式（I）化合物与4-（1,1-二甲基乙基）-4的化合物的摩尔比 甲氧基二苯甲酰甲烷为0.8或更高。

公开(公告)号：US4950478A

公开(公告)日：1990-08-21

申请号：US573143

申请日：1984-01-23

Applicant: Gerard Lang ,  Andre Deflandre ,  Irena Beck

Inventor： Gerard Lang ,  Andre Deflandre ,  Irena Beck

IPC: A61K8/35 ,  A61K8/41 ,  A61K8/46 ,  A61K8/92 ,  A61Q17/04

CPC classification number: A61K8/35 ,  A61K8/416 ,  A61K8/466 ,  A61K8/922 ,  A61Q17/04 ,  Y10S424/05

Abstract: The present invention relates to a cosmetic composition comprising a natural essence containing a phototoxic dose of furocoumarin, and 0.01 to 2% by weight of at least one benzylidenecamphor derivative filtering out UV-A radiation and chosen from among 3-p-oxybenzylidenebornan-2-ones, 3,3'-terephthalylidenedicamphors optionally sulfonated in the 10-position of the camphor, p-(3-methylidenecamphor)-cinnamic acid derivatives, 3,3'-terephthalylidenedicampho-10-sulfonamides or 3,3'-terephthalylidenedicampho-10,10'-disulfonamides.It is also possible to incorporate into the composition a UV-B filter chosen from among: benzylidenecamphor, p-methylbenzylidenecamphor, benzylidenecamphor derivatives containing a quaternary ammonium radical on the benzene nucleus in the para position relative to the bornylidene radical, benzylidenecamphor derivatives sulphonated on the methyl radical in the 10-position of the camphor or in the 3'-position of 4'-position on the benzene nucleus, p-methylbenzylidene-camphor derivatives substituted on the p-methyl group, or other 3-benzylidenecamphor derivatives filtering out UV-B radiation.The effect of the benzylidenecamphor derivative is to deactivate the furocoumarins excited by UV radiation and to reduce their phototoxicity.

Abstract translation: 本发明涉及一种化妆品组合物，其包含含有光毒性剂量的呋喃香豆素的天然精华和0.01至2重量％的过滤掉UV-A辐射的至少一种亚苄基猝灭衍生物，并选自3-对 - 氧亚苄基 - 樟脑的10位任选磺化的3,3'-对苯二甲酰脒，对 - （3-甲基en or or or am am am am am am am am am am am am am am am am am am am 10 10 10 10，，，，10 3 10 10 10 10 10 10 10 10 10 10 10 10 ，10'-二磺酰胺。 也可以在组合物中加入选自以下的UV-B过滤器：亚苄基樟脑，对甲基亚苄基樟脑，在相对于甘草基的对位的苯核上含有季铵基的亚苄基or or衍生物，其上磺化的亚苄基am or衍生物 樟脑10位或甲苯4'-位的3'-位上的甲基，对甲基取代的对甲基亚苄基 - 樟脑衍生物或其它3-亚苄基am or衍生物过滤出紫外 -B辐射。 亚苄基脒衍生物的作用是使由紫外线辐射激发的呋喃香豆素失活并降低其光毒性。

公开(公告)号：US4731200A

公开(公告)日：1988-03-15

申请号：US885392

申请日：1986-07-18

Applicant: Gerard Lang ,  Andre Deflandre ,  Irena Beck

Inventor： Gerard Lang ,  Andre Deflandre ,  Irena Beck

IPC: C09K3/00 ,  A61K8/00 ,  A61K8/30 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K8/92 ,  A61K8/97 ,  A61K31/125 ,  A61K31/37 ,  A61P17/00 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/02 ,  A61Q90/00 ,  C11B9/00 ,  A61K7/46

CPC classification number: A61K8/416 ,  A61K8/35 ,  A61K8/466 ,  A61K8/922 ,  A61Q17/04

Abstract: The present invention relates to an alcoholic or aqueous-alcoholic composition comprising a natural essence containing a phototoxic dose of furocoumarin, and 0.01 to 2% by weight of at least one benzylidenecamphor derivative filtering out UV-A radiation and chosen from among 3-p-oxybenzylidenebornan-2-ones, 3,3'-terephthalylidenedicamphors optionally sulphonated in the 10-position of the camphor, p-(3-methylidenecamphor)cinnamic acid derivatives, 3,3'-terephthalylidenedicampho-10-sulphonamides or 3,3'-terephthalylidenedicampho-10,10'-disulphonamides. It is also possible to incorporate into the composition a UV-B filter chosen from among benzylidenecamphor, p-methylbenzylidenecamphor, benzylidenecamphor derivatives containing a quaternary ammonium radical on the benzene nucleus in the para position relative to the bornylidene radical, benzylidenecamphor derivatives sulphonated on the methyl radical in the 10-position of the camphor or in the 3'-position or 4'-position on the benzene nucleus, p-methylbenzylidenecamphor derivatives substituted on the p-methyl group, or other 3-benzylidenecamphor derivatives filtering out UV-B radiation.Application: perfumes, toilet waters, eaux de cologne and shaving lotions.

Abstract translation: 本发明涉及包含含有光毒剂量的呋喃香豆素的天然精华和0.01-2重量％的至少一种亚苄基猝灭衍生物的酒精或含水醇组合物，其过滤掉UV-A辐射并选自3-对 - 对苯二甲酰亚苯基-2-酮，樟脑10位中任选磺化的3,3'-对苯二甲酰基樟脑，对 - （3-甲基亚甲基樟脑）肉桂酸衍生物，3,3'-对苯二甲酰亚苯基二磷杂-10-磺酰胺或3,3'- 对苯二甲酰己二磷-10,10'-二磺酰胺。 在组合物中还可以将选自亚苄基樟脑，对甲基亚苄基樟脑中的UV-B过滤器，在相对于亚生乙酰基的对位的苯核上含有季铵基的亚苄基am or衍生物，在甲基上磺化的亚苄基am or衍生物 在樟脑的10位或苯核上的3'-位或4'-位，在对甲基上取代的对甲基亚苄基脒衍生物或其它过滤出UV-B辐射的3-亚苄基or or衍生物 。 适用范围：香水，马桶水，洗发水及洗发水。

公开(公告)号：US5223533A

公开(公告)日：1993-06-29

申请号：US501260

申请日：1990-03-29

Applicant: Serge Forestier ,  Alain LaGrange ,  Gerard Lang ,  Andre Deflandre ,  Bernadette Luppi

Inventor： Serge Forestier ,  Alain LaGrange ,  Gerard Lang ,  Andre Deflandre ,  Bernadette Luppi

IPC: A61K31/12 ,  A61K8/00 ,  A61K8/04 ,  A61K8/30 ,  A61K8/33 ,  A61K8/34 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K8/92 ,  A61K31/34 ,  A61K31/341 ,  A61P29/00 ,  A61P37/08 ,  A61Q1/00 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q17/04 ,  C07C45/62 ,  C07C45/67 ,  C07C45/68 ,  C07C45/74 ,  C07C45/78 ,  C07C49/747 ,  C07C49/753 ,  C07C309/24 ,  C07D307/32 ,  C07D307/94

CPC classification number: C07D307/32 ,  A61K8/35 ,  A61K8/4973 ,  A61Q17/04 ,  C07C309/24 ,  C07C45/62 ,  C07C45/673 ,  C07C45/74 ,  C07C45/78 ,  C07C49/747 ,  C07C49/753 ,  C07C2102/42

Abstract: The invention relates to the benzylcyclanone derivatives of formula: ##STR1## where R.sub.1 and R.sub.3 denote H, OH, linear or branched C.sub.1 -C.sub.8 alkyl or linear or branched C.sub.1 -C.sub.8 alkoxy, R.sub.2 and R.sub.4 represent H or OH, at least one of the two being OH, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 represent H, C.sub.1 -C.sub.18 alkyl, aralkyl or aryl, it being possible for R.sub.5 and R.sub.6 and/or R.sub.7 and R.sub.8 to form an optionally substituted, saturated C.sub.5 -C.sub.12 ring, X represents O or --(CR.sub.9 R.sub.10).sub.n with n=1 or 2 and R.sub.9 and R.sub.10 represent H or CH.sub.3 ; if X represents --(CR.sub.9 R.sub.10).sub.n, R.sub.6 and R.sub.8, with the atoms of the ring to which they are attached, form a bicyclic system having 7 or 8 carbon atoms; if X represents --(CR.sub.9 R.sub.10).sub.n with n=1, R.sub.9 and R.sub.10 =CH.sub.3, R.sub.5 =H and R.sub.6 and R.sub.8, with the atoms of the ring to which are attached, form a bicyclic system having 7 carbon atoms, R.sub.7 can represent a --CH.sub.2 SO.sub.3 H residue, optionally in salt form.Process for preparing these compounds and their use as antioxidants and medicinal products for the treatment of skin allergies and inflammations.

Abstract translation: 本发明涉及下式的苄基环己酮衍生物：其中R 1和R 3表示H，OH，直链或支链C 1 -C 8烷基或直链或支链C 1 -C 8烷氧基，R 2和R 4表示H或OH， 两个中的至少一个是OH，R5，R6，R7和R8表示H，C1-C18烷基，芳烷基或芳基，R5和R6和/或R7和R8可能形成任选取代的饱和C5-C12 X表示O或 - （CR 9 R 10）n，n = 1或2，R 9和R 10表示H或CH 3; 如果X表示 - （CR9R10）n，R6和R8与它们所连接的环的原子形成具有7或8个碳原子的双环体系; 如果X代表具有n = 1的 - （CR 9 R 10）n，R 9和R 10 = CH 3，R 5 = H，并且R 6和R 8与连接的环的原子形成具有7个碳原子的双环体系， 任选呈盐形式的-CH 2 SO 3 H残基。 制备这些化合物的方法及其作为抗氧化剂和药物用于治疗皮肤过敏和炎症的用途。

公开(公告)号：US5178852A

公开(公告)日：1993-01-12

申请号：US500940

申请日：1990-03-29

Applicant: Serge Forestier ,  Alain Lagrange ,  Gerard Lang ,  Andre Deflandre ,  Bernadette Luppi

Inventor： Serge Forestier ,  Alain Lagrange ,  Gerard Lang ,  Andre Deflandre ,  Bernadette Luppi

IPC: A61K31/125 ,  A61K8/00 ,  A61K8/04 ,  A61K8/30 ,  A61K8/34 ,  A61K8/35 ,  A61K8/92 ,  A61P29/00 ,  A61P37/08 ,  A61Q1/00 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/06 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q17/00 ,  A61Q17/04 ,  C07C45/67 ,  C07C45/74 ,  C07C49/747 ,  C07C49/753 ,  C09K3/00 ,  C09K15/08

CPC classification number: C07C49/753 ,  A61K8/35 ,  A61Q17/04 ,  C07C45/673 ,  C07C45/74 ,  C07C49/747 ,  Y10S514/844 ,  Y10S514/887 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/962 ,  Y10S514/972

Abstract: The invention relates to cosmetic and pharmaceutical compositions containing the derivatives of benzylidenecamphor of formula: ##STR1## where R.sub.1 denotes H, OH, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.8 alkoxy, R.sub.3 denotes OH, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.8 alkoxy, or else when R.sub.1 denotes H or OH, R.sub.3 can represent C.sub.1 -C.sub.8 alkyl, R.sub.2 and R.sub.4 denote H or OH, at least one of the radicals R.sub.2 and R.sub.4 representing OH.The compounds (I) are wide-band sunscreens and antioxidants, and are utilized in the treatment of cutaneous inflammations and allergies.

Abstract translation: 本发明涉及含有下式的亚苄基the the衍生物的化妆品和药物组合物：其中R1表示H，OH，C1-C3烷基或C1-C8烷氧基，R3表示OH，C1-C3烷基或C1- C8烷氧基，或者当R1表示H或OH时，R3可以表示C1-C8烷基，R2和R4表示H或OH，R2和R4中的至少一个表示OH。 化合物（I）是宽带防晒剂和抗氧化剂，用于治疗皮肤炎症和过敏。