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公开(公告)号：US20200030080A1
公开(公告)日：2020-01-30
申请号：US16410379
申请日：2019-05-13
申请人： E. Aubrey Woodroof
发明人： E. Aubrey Woodroof
摘要： An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being salinomycin.
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公开(公告)号：US20180250114A1
公开(公告)日：2018-09-06
申请号：US15469891
申请日：2017-03-27
CPC分类号： A61F2/0063 , A61F2/0077 , A61F2002/0068 , A61F2002/009 , A61F2250/0067 , A61L31/028 , A61L31/048 , A61L31/06 , A61L31/146 , A61L31/16 , D04B1/16 , D10B2403/0112 , D10B2509/08
摘要： An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations.An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.
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公开(公告)号：US20140343676A1
公开(公告)日：2014-11-20
申请号：US13897430
申请日：2013-05-19
申请人： Aubrey Woodroof
发明人： Aubrey Woodroof
IPC分类号： A61F2/10
CPC分类号： A61L15/26 , A61F13/00008 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00063 , A61F13/02 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/60 , A61L2300/30 , D04B1/16 , D10B2403/0112 , D10B2509/022
摘要： An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations.
摘要翻译： 提出了一种改进的皮肤替代物，其由有机织物尼龙织物层支撑的有机硅层构成，硅氧烷层具有规则的狭缝图案，允许临床医生通过向皮肤施加张力来调整皮肤替代物的孔隙度 代替差异地打开狭缝。 各种治疗物质可以用于皮肤替代物以促进愈合，包括芦荟和其他药物制剂。
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公开(公告)号：US20100331751A1
公开(公告)日：2010-12-30
申请号：US12493238
申请日：2009-06-28
申请人： E. Aubrey Woodroof , Amy Moss , Victoria Vandenberg , Karla Alvey
发明人： E. Aubrey Woodroof , Amy Moss , Victoria Vandenberg , Karla Alvey
CPC分类号： A61F13/104 , A61F13/064 , A61F2013/00157
摘要： An improved burn glove and sock is presented comprised of non-biological materials produced with a series of regularly-spaced pores and uniform three dimensional nylon structure/weave netting. Incorporated into the silicone/nylon weave structure are collagen peptides and other biological and non-biological agents selected for their therapeutic effect on burn wounds.The gloves and sock come in left and right shapes, the gloves with opposable thumbs, an advance for the burn glove industry. The items are assembled from state-of-the-art skin substitute material in use for burn and wound dressings.
摘要翻译： 提出了一种改进的烧伤手套和袜子，其包括由一系列规则间隔的孔和均匀的三维尼龙结构/织网生产的非生物材料。 加入有机硅/尼龙织造结构中是胶原肽和其他生物和非生物剂，其选择用于治疗烧伤伤口。 手套和袜子都是左右的形状，手套有相反的拇指，是烧伤手套行业的进步。 这些物品由用于烧伤和伤口敷料的最先进的皮肤替代材料组装。
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公开(公告)号：US11229514B2
公开(公告)日：2022-01-25
申请号：US16410379
申请日：2019-05-13
申请人： E. Aubrey Woodroof
发明人： E. Aubrey Woodroof
摘要： An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being salinomycin.
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公开(公告)号：US20180140468A1
公开(公告)日：2018-05-24
申请号：US15396720
申请日：2017-01-02
申请人： E. Aubrey Woodroof
发明人： E. Aubrey Woodroof
CPC分类号： A61F13/104 , A61L15/425 , A61L15/44 , A61L27/54 , A61L27/56 , A61L27/60 , A61L31/146 , A61L31/16 , A61L2300/30 , A61M35/00
摘要： An improved glove-shaped dressing for hands is presented which enables quicker wound closure and a lower anesthesia requirement, comprised of two hand-shaped pieces of an improved prior-art skin-substitute brought together with a sealing means and fitted to the hand with surgical staples.
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公开(公告)号：US09155820B2
公开(公告)日：2015-10-13
申请号：US12558563
申请日：2009-09-13
CPC分类号： A61L27/60
摘要： An improved skin substitute production method is presented that minimizes destruction of the nylon weave netting that comprises the skin substitute at the pore holes of the skin substitute membrane, The skin substitute is comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon weave netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/1 denier).
摘要翻译： 提出了一种改进的皮肤替代生产方法，其最小化了在皮肤替代膜的孔孔处包含皮肤替代物的尼龙编织网的破坏。皮肤替代物由用一系列规则间隔的孔产生的非生物材料组成 和尼龙编织网。 顶部组分是薄（约0.001“厚）硅氧烷弹性体，其中孔孔已被真空拉拔; 物理上附着于硅氧烷弹性体的是细针织尼龙织物（12/1,15/1旦尼尔）。
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公开(公告)号：US07815931B2
公开(公告)日：2010-10-19
申请号：US12326373
申请日：2008-12-02
IPC分类号： A61F13/00
摘要： An improved skin substitute is presented comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon weave netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/1 denier); incorporated into the silicone/nylon structure are collagen peptides [about 10 micrograms per square centimeter of Porcine type 1—“the active component”] without cross-linking agent to enable a quick interaction with fibrin in the wound to achieve acute adherence. The vacuum-pulled holes provide a range of porosities to ensure minimum fluid accumulation beneath the skin substitute without wound desiccation. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″. Providing a structure that has better acute adherence and minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing. Larger pieces of this skin substitute can be made to cover larger wounds, unlike previous skin substitutes.
摘要翻译： 提出了一种改进的皮肤替代品，包括由一系列规则间隔的孔和尼龙编织网生产的非生物材料。 顶部组分是薄（约0.001“厚）硅氧烷弹性体，其中孔孔已被真空拉拔; 物理上附着于硅氧烷弹性体的是精细针织尼龙织物（12/1,15/1旦尼尔）; 掺入硅酮/尼龙结构中的是胶原肽[约10微克每平方厘米的猪类型1-“活性组分”]，无交联剂，以使与伤口中的纤维蛋白快速相互作用以达到急性依从性。 真空拉孔提供一系列的孔隙度，以确保在皮肤替代物下面的最小的液体积聚而无伤口干燥。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以“1/3”为中心的孔中。 提供在临时皮肤替代物下具有更好的急性依从性和最小的液体积聚的结构，其将减少感染并发症并最大限度地伤口愈合。 与以前的皮肤替代品不同，这种皮肤替代物的较大片可以覆盖较大的伤口。
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公开(公告)号：US20090232878A1
公开(公告)日：2009-09-17
申请号：US12326373
申请日：2008-12-02
摘要： An improved skin substitute is presented comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon weave netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/1 denier); incorporated into the silicone/nylon structure are collagen peptides [about 10 micrograms per square centimeter of Porcine type 1—“the active component”] without cross-linking agent to enable a quick interaction with fibrin in the wound to achieve acute adherence.The vacuum-pulled holes provide a range of porosities to ensure minimum fluid accumulation beneath the skin substitute without wound desiccation. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″. Providing a structure that has better acute adherence and minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing. Larger pieces of this skin substitute can be made to cover larger wounds, unlike previous skin substitutes.
摘要翻译： 提出了一种改进的皮肤替代品，包括由一系列规则间隔的孔和尼龙编织网生产的非生物材料。 顶部组分是薄（约0.001“厚）的有机硅弹性体，其中孔孔已被真空拉制; 物理上附着于硅氧烷弹性体的是精细针织尼龙织物（12/1,15/1旦尼尔）; 掺入硅酮/尼龙结构中的是胶原肽[约10微克每平方厘米的猪类型1-“活性组分”]，无交联剂，以使与伤口中的纤维蛋白快速相互作用以达到急性依从性。 真空拉孔提供一系列的孔隙度，以确保在皮肤替代物下面的最小的液体积聚而无伤口干燥。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以1/4“-1 / 3”为中心的孔中。 提供在临时皮肤替代物下具有更好的急性依从性和最小的液体积聚的结构，其将减少感染并发症并最大限度地伤口愈合。 与以前的皮肤替代品不同，这种皮肤替代物的较大片可以覆盖较大的伤口。
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公开(公告)号：US4828561A
公开(公告)日：1989-05-09
申请号：US370977
申请日：1982-04-22
申请人： E. Aubrey Woodroof
发明人： E. Aubrey Woodroof
CPC分类号： A61L27/18 , A61L15/44 , A61L27/22 , A61L27/222 , A61L33/0011 , A61F2310/00383 , A61L2300/214 , A61L2300/22 , A61L2300/23 , A61L2300/252 , A61L2300/42 , Y10S602/90
摘要： Bio- and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing, breast prostheses and implants. Detailed procedures and various products are described.
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