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    TEMPORARY SKIN SUBSTITUTE COMPRISED OF BIOLOGICAL COMPOUNDS OF PLANT AND ANIMAL ORIGINS
    2.
    发明申请
    TEMPORARY SKIN SUBSTITUTE COMPRISED OF BIOLOGICAL COMPOUNDS OF PLANT AND ANIMAL ORIGINS 审中-公开
    由植物和动物原始生物化学组成的临时皮肤替代物

    公开(公告)号：US20090234305A1

    公开(公告)日：2009-09-17

    申请号：US12348412

    申请日：2009-01-05

    申请人： Ernest Aubrey Woodroof

    发明人： Ernest Aubrey Woodroof

    IPC分类号： A61F13/00

    CPC分类号： A61L27/18 ,  A61F13/00008 ,  A61F13/00021 ,  A61F13/00063 ,  A61F2013/00157 ,  A61F2013/00382 ,  A61F2013/00527 ,  A61F2013/00553 ,  A61F2013/00927 ,  A61L27/56 ,  A61L27/60 ,  C08L83/04 ,  C08L77/00

    摘要： An improved skin substitute is presented comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon mesh netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/2 denier); incorporated into the silicone/nylon structure are several wound healing agents, including Vitamin E, Vitamin C, Chondroitin 4 Sulfate, Chondroitin 6 Sulfate and Immuno-10 (a highly purified fraction of Aloe Vera) in addition to porcine collagen peptide.The holes in the skin substitute provide a range of porosities to ensure minimum fluid accumulation beneath the skin substitute without wound desiccation. The three-dimensional nature of the nylon mesh in addition to the use of collagen peptides provides better acute adherence with a structure that supports the growth of new skin cells. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″, providing minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing.

    摘要翻译： 提出了一种改进的皮肤替代品，其包括由一系列规则间隔的孔和尼龙网状网制成的非生物材料。 顶部组分是薄（约0.001“厚）的有机硅弹性体，其中孔孔已被真空拉制; 物理上附着于有机硅弹性体的是细针织尼龙织物（12 / 1,15 / 2旦尼尔）; 含有维生素E，维生素C，硫酸软骨素4，硫酸软骨素6和免疫10（高纯度芦荟成分）除了猪胶原肽外，还含有几种伤口愈合剂。 皮肤替代品中的孔提供一系列孔隙度，以确保皮肤替代物下方的最小液体积聚而不伤口干燥。 除了使用胶原肽之外，尼龙网的三维性质提供了与支持新皮肤细胞生长的结构的更好的急性粘附。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以“1/3”至1/3“为中心的孔中，在临时皮肤替代物之下提供最小的流体积聚，这将减少感染并发症并最大限度地伤口愈合 。

    Laser-Perforated Skin Substitute
    3.
    发明申请
    Laser-Perforated Skin Substitute 审中-公开
    激光穿孔皮肤替代品

    公开(公告)号：US20090230592A1

    公开(公告)日：2009-09-17

    申请号：US12049321

    申请日：2008-03-15

    申请人： Aubrey Woodroof

    发明人： Aubrey Woodroof

    IPC分类号： B29C71/04 ,  B29C35/02 ,  B29C71/00

    CPC分类号： A61F13/00987 ,  A61F13/0276 ,  A61F2013/00157 ,  A61F2013/00519 ,  A61F2013/00863 ,  A61F2013/00876 ,  A61F2013/00927

    摘要： The Temporary Skin Substitute of this invention consists of three components: The top component is a thin (approximately 0.001″ thick) silicone elastomer in which laser holes have been drilled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/1 denier); incorporated into the silicone/nylon structure are collagen peptides [about 10 micrograms per square centimeter of Porcine type 1—“the active component”] without cross-linking agent to enable a quick interaction with fibrin in the wound to achieve acute adherence. The laser drilled holes provide a wide range of porosity to ensure minimum fluid accumulation beneath the Temporary Skin Substitute without wound desiccation. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″. Providing a structure that has better acute adherence and minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing. Larger pieces of this skin substitute can be made to cover larger wounds, unlike previous skin substitutes.

    摘要翻译： 本发明的临时皮肤替代物由三个组分组成：顶部组分是已经钻出激光孔的薄（约0.001“厚）硅氧烷弹性体; 物理上附着于硅氧烷弹性体的是精细针织尼龙织物（12/1,15/1旦尼尔）; 掺入硅酮/尼龙结构中的是胶原肽[约10微克每平方厘米的猪类型1-“活性组分”]，无交联剂，以使与伤口中的纤维蛋白快速相互作用以达到急性依从性。 激光钻孔提供广泛的孔隙度，以确保临时皮肤替代物下面的最小液体积聚而无伤口干燥。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以1/4“-1 / 3”为中心的孔中。 提供在临时皮肤替代物下具有更好的急性依从性和最小的液体积聚的结构，其将减少感染并发症并最大限度地伤口愈合。 与以前的皮肤替代品不同，这种皮肤替代物的较大片可以覆盖较大的伤口。

    Bio compatible and blood compatible materials and methods
    4.
    发明授权
    Bio compatible and blood compatible materials and methods 失效
    生物兼容和血液相容的材料和方法

    公开(公告)号：US4820302A

    公开(公告)日：1989-04-11

    申请号：US392018

    申请日：1982-06-25

    申请人： E. Aubrey Woodroof

    发明人： E. Aubrey Woodroof

    IPC分类号： A61L27/18 ,  A61L33/00 ,  A61F2/52

    CPC分类号： A61L33/0011 ,  A61L27/18

    摘要： Bio- and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing, breast prostheses and implants. Detailed procedures and various products are described.

    摘要翻译： 通过处理底物的表面以提供反应性伯或仲胺基团位点来制备生物和血液相容的材料，其通过用二醛或芳基氯化物处理而活化，用于以足以提供相容性的量与生物偶联。 使用特定的基底，例如顺应性和弹性材料，例如织物 - 弹性体膜基质，导致具有作为热烧伤敷料，乳房假体和植入物的有利品质的产品。 描述详细的程序和各种产品。

    Hernia repair device and method
    6.
    发明授权
    Hernia repair device and method 有权

    公开(公告)号：US10182900B2

    公开(公告)日：2019-01-22

    申请号：US15469891

    申请日：2017-03-27

    申请人： E. Aubrey Woodroof ,  Lipton Laverne Martin

    发明人： E. Aubrey Woodroof ,  Lipton Laverne Martin

    IPC分类号： A61F2/00 ,  A61L31/02 ,  A61L31/04 ,  A61L31/16 ,  A61L31/14 ,  A61L31/06

    摘要： An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations.An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.

    Bio compatible and blood compatible materials and methods
    9.
    发明授权
    Bio compatible and blood compatible materials and methods 失效
    生物兼容和血液相容的材料和方法

    公开(公告)号：US4725279A

    公开(公告)日：1988-02-16

    申请号：US738282

    申请日：1985-05-28

    申请人： E. Aubrey Woodroof

    发明人： E. Aubrey Woodroof

    IPC分类号： A61F2/00 ,  A61L15/44 ,  A61L27/22 ,  A61L33/00 ,  A61F2/10 ,  A61F13/00 ,  A61L15/00

    CPC分类号： A61L15/44 ,  A61L27/22 ,  A61L27/222 ,  A61L33/0011 ,  A61F2310/00383 ,  A61L2300/21 ,  A61L2300/214 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/42 ,  Y10S128/08 ,  Y10S424/13 ,  Y10S514/801

    摘要： Bio-and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing. Detailed procedures and various products are described including gloves and sleeves and tubes with or without adhesive to facilitate formation of sheet materials into various forms and products. The products may have small holes provided therein for the rapid passage of accumulated fluid away from the wound or infusion of liquid materials to the wound site.

    摘要翻译： 通过处理底物的表面以提供反应性伯或仲胺基团位点来制备生物和血液相容的材料，其通过用二醛或芳基氯化物处理而活化，用于以足以提供相容性的量与生物偶合。 使用特定的基底，例如顺应性和弹性材料，例如织物 - 弹性体膜基质，导致具有作为热烧伤敷料的有利品质的产品。 描述了详细的程序和各种产品，包括具有或不具有粘合剂的手套和套筒和管，以便于将片材形成为各种形式和产品。 产品可以具有设置在其中的小孔，用于使积聚的液体快速通过液体材料的伤口或输液到伤口部位。