公开(公告)号：US20190017101A1

公开(公告)日：2019-01-17

申请号：US16006586

申请日：2018-06-12

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12Q1/6811 ,  G01N33/94

CPC classification number: C12Q1/6811 ,  C40B30/04 ,  C40B40/06 ,  G01N33/948 ,  C12Q2525/205 ,  C12Q2565/101

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as tetrahydrocannabinol (THC).

公开(公告)号：US20180100152A1

公开(公告)日：2018-04-12

申请号：US15712042

申请日：2017-09-21

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12Q1/6811

CPC classification number: C12N15/115 ,  C12N2310/16 ,  C12N2320/13 ,  C12Q1/6811 ,  C12Q1/70 ,  C12Q2525/205

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules such as chikungunya viral proteins, such as chikungunya envelope protein E1.

公开(公告)号：US20180030447A1

公开(公告)日：2018-02-01

申请号：US15663681

申请日：2017-07-28

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12N15/10

CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12N2310/16 ,  C12N2330/31

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as ricin and related molecules, such as ricin B chain (RTB).

公开(公告)号：US20170233738A1

公开(公告)日：2017-08-17

申请号：US15436576

申请日：2017-02-17

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12N15/10

CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12N2310/16 ,  C12N2320/13

Abstract: This invention relates to functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, more particularly to functional ligands with binding affinity to metabolites of nerve agents, and further particularly to functional ligands with binding affinity to metabolites of VX-acid (metabolite of VX nerve agent) and GB-acid (metabolite of sarin nerve agent).

公开(公告)号：US20240110237A1

公开(公告)日：2024-04-04

申请号：US18227386

申请日：2023-07-28

Applicant: BASE PAIR BIOTECHNOLOGIES, INC.

Inventor： Jasmine Kaur ,  Rafal Drabek ,  George W. Jackson ,  Robert Batchelor ,  Alexander Chiu

IPC: C12Q1/6874 ,  C12N15/10 ,  C12N15/115 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04

CPC classification number: C12Q1/6874 ,  C12N15/1048 ,  C12N15/115 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04 ,  C12N2310/16 ,  C12N2330/31

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

公开(公告)号：US20210348226A1

公开(公告)日：2021-11-11

申请号：US17152007

申请日：2021-01-19

Applicant: BASE PAIR BIOTECHNOLOGIES, INC.

Inventor： Jasmine Kaur ,  Rafal Drabek ,  George W. Jackson ,  Robert Batchelor ,  Alexander Chiu

IPC: C12Q1/6874 ,  C12N15/115 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as opioids and opioid derivatives.

公开(公告)号：US10927381B2

公开(公告)日：2021-02-23

申请号：US16677433

申请日：2019-11-07

Applicant: BASE PAIR BIOTECHNOLOGIES, INC.

Inventor： George W. Jackson ,  Robert Batchelor ,  Truong Nguyen ,  Victoria Singer ,  Garam Lee ,  Rafal Drabek

IPC: C07H21/00 ,  C12N15/115 ,  C40B30/04 ,  C40B10/00

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as molecules used proteins or peptides, such as LL37.

公开(公告)号：US20210041470A1

公开(公告)日：2021-02-11

申请号：US16832019

申请日：2020-03-27

Applicant: Base Pair Biotechnologies, Inc.

Inventor： Jasmine Kaur ,  Rafal Drabek ,  George W. Jackson ,  Robert Batchelor

IPC: G01N33/94 ,  C12N15/11 ,  G01N33/50

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as opioids and opioid metabolites.

公开(公告)号：US20190092817A1

公开(公告)日：2019-03-28

申请号：US15920394

申请日：2018-03-13

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C07K14/00 ,  C12N15/62 ,  C07K14/47 ,  C12N9/12

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as peptides and proteins, such as Erk1, Erk3, Muc1, Transgelin, Akt and ACTH

公开(公告)号：US20180237782A1

公开(公告)日：2018-08-23

申请号：US15893532

申请日：2018-02-09

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12N15/10

CPC classification number: C12Q1/6874 ,  C12N15/1048 ,  C12N15/115 ,  C12N2310/16 ,  C12N2330/31 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as amino acids, such as citrulline, and to target molecules such as crystallin or its subunits, such as alpha crystallin B-chain (CRYAB).