公开(公告)号：US08840790B2

公开(公告)日：2014-09-23

申请号：US13095633

申请日：2011-04-27

申请人： Christopher J. Wegener ,  Marc N. Weasler ,  Benjamin E. Kusters ,  Daniel R. Boggs ,  Kyungyoon Min

发明人： Christopher J. Wegener ,  Marc N. Weasler ,  Benjamin E. Kusters ,  Daniel R. Boggs ,  Kyungyoon Min

IPC分类号： B01D61/32 ,  A61M1/34 ,  B01D65/02 ,  B01D61/22

CPC分类号： B01D65/02 ,  A61M1/3496 ,  B01D61/22 ,  B01D61/32 ,  B01D2311/14 ,  B01D2311/16 ,  B01D2311/165 ,  B01D2321/40

摘要： Systems and methods of controlling fouling during a filtration procedure are described. A plasmapheresis method includes accepting a selection of a plasma flow rate and predicting an estimated procedure end time based at least partially on a plasma collection target volume. The method also includes flowing blood past a membrane and changing a plasma flow rate until the selected plasma flow rate through the membrane is achieved. The method also includes determining an acceptable rate of pressure change with time for respective times to the estimated procedure end time, the acceptable fouling rate limit being associated with a system pressure and adjusting the plasma flow rate based on the determined acceptable rate of pressure change with time.

摘要翻译： 描述了在过滤过程中控制结垢的系统和方法。 血浆置换法包括接受血浆流速的选择并且至少部分地基于等离子体收集目标体积来预测估计的过程结束时间。 该方法还包括使血液流过膜并改变等离子体流速，直到达到所选择的通过膜的等离子体流速。 该方法还包括在相应时间内估计可接受的压力变化速率到估计的程序结束时间，可接受的结垢速率极限与系统压力相关联并且基于所确定的可接受的压力变化速率来调节等离子体流速 时间。

公开(公告)号：US20130341274A1

公开(公告)日：2013-12-26

申请号：US14003290

申请日：2012-03-09

申请人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min

发明人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min

IPC分类号： A61M1/34

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

摘要翻译： 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋 这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。