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公开(公告)号：US09895482B2
公开(公告)日：2018-02-20
申请号：US14003298
申请日：2012-03-09
IPC分类号： A61M1/34 , A61M1/36 , A61M1/02 , B01D61/18 , B01D63/06 , B01D63/16 , A61M1/38 , A61M1/26 , B01D33/06 , G06F19/00
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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2.发明授权Membrane separation devices, systems and methods employing same and data management systems and methods 有权膜分离装置，采用相同的系统和方法以及数据管理系统和方法公开(公告)号：US09381291B2
公开(公告)日：2016-07-05
申请号：US14003273
申请日：2012-03-09
申请人： Daniel R. Boggs , Mark J. Brierton , Benjamin E. Kusters , Kyungyoon Min , Christopher J. Wegener
发明人： Daniel R. Boggs , Mark J. Brierton , Benjamin E. Kusters , Kyungyoon Min , Christopher J. Wegener
IPC分类号： A61M1/34 , A61M1/26 , B01D63/16 , A61M1/02 , B01D61/18 , B01D63/06 , A61M1/38 , A61M1/36 , G06F19/00
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译： 公开了一种用于血液处理程序的膜分离装置。 在一个实施方案中，提供了纺丝膜分离器，其中在纺丝膜和壳体之间的间隙中形成至少两个区域或区域，使得两个区域之间的流体的混合被相关联的径向肋或脊部抑制 通过纺丝膜减少纺丝膜和壳体之间的间隙以限定两个流体区域，脊部将两个区域中的流体隔离以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单位分离成选定的血液成分，例如浓缩红细胞和血浆，以单次从供体中直接收集红细胞和血浆，并进行细胞洗涤。 还公开了数据管理系统和方法以及启动方法。
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3.发明授权公开(公告)号：US08840790B2
公开(公告)日：2014-09-23
申请号：US13095633
申请日：2011-04-27
申请人： Christopher J. Wegener , Marc N. Weasler , Benjamin E. Kusters , Daniel R. Boggs , Kyungyoon Min
发明人： Christopher J. Wegener , Marc N. Weasler , Benjamin E. Kusters , Daniel R. Boggs , Kyungyoon Min
CPC分类号： B01D65/02 , A61M1/3496 , B01D61/22 , B01D61/32 , B01D2311/14 , B01D2311/16 , B01D2311/165 , B01D2321/40
摘要： Systems and methods of controlling fouling during a filtration procedure are described. A plasmapheresis method includes accepting a selection of a plasma flow rate and predicting an estimated procedure end time based at least partially on a plasma collection target volume. The method also includes flowing blood past a membrane and changing a plasma flow rate until the selected plasma flow rate through the membrane is achieved. The method also includes determining an acceptable rate of pressure change with time for respective times to the estimated procedure end time, the acceptable fouling rate limit being associated with a system pressure and adjusting the plasma flow rate based on the determined acceptable rate of pressure change with time.
摘要翻译： 描述了在过滤过程中控制结垢的系统和方法。 血浆置换法包括接受血浆流速的选择并且至少部分地基于等离子体收集目标体积来预测估计的过程结束时间。 该方法还包括使血液流过膜并改变等离子体流速，直到达到所选择的通过膜的等离子体流速。 该方法还包括在相应时间内估计可接受的压力变化速率到估计的程序结束时间，可接受的结垢速率极限与系统压力相关联并且基于所确定的可接受的压力变化速率来调节等离子体流速 时间。
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4.发明申请MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 有权膜分离装置，系统和使用方法以及数据管理系统和方法公开(公告)号：US20130341274A1
公开(公告)日：2013-12-26
申请号：US14003290
申请日：2012-03-09
IPC分类号： A61M1/34
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译： 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋 这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。
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5.发明申请DEVICE AND METHOD FOR PROCESSING AND PRODUCING AUTOLOGOUS PLATELET-RICH PLASMA 有权用于处理和生产自动化等离子体的装置和方法公开(公告)号：US20150060363A1
公开(公告)日：2015-03-05
申请号：US14014542
申请日：2013-08-30
IPC分类号： A61M1/34
CPC分类号： A61M1/3496 , A61M1/0218 , A61M1/265 , A61M2205/103 , A61M2205/75 , B01D63/16 , B01D2317/02 , B01D2319/02 , B01D2319/06
摘要： A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma. A first waste container is in fluid communication with the first stage of the separator for receiving separated red blood cells, while a second waste container is in fluid communication with the second stage of the separator for receiving separated plasma. An outlet line is in fluid communication with the second stage of the separator for receiving platelet rich plasma, and a reinfusion container is removably connected to the outlet line for receiving platelet rich plasma from the second stage of the separator.
摘要翻译： 提供了一种系统和方法，包括一体化的一次性使用试剂盒，用于处理全血以产生富血小板血浆。 两级纺丝膜分离器具有第一阶段，用于接收全血并将血浆和血小板基本上全部红细胞分离，以及用于从血浆中进一步分离富血小板血浆的第二阶段。 第一废物容器与分离器的第一级流体连通，用于接收分离的红细胞，而第二废物容器与分离器的第二级流体连通以接收分离的等离子体。 出口管线与分离器的第二级流体连通，用于接收富血小板血浆，并且再输注容器可移除地连接到出口管线，用于从分离器的第二级接收富血小板血浆。
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6.发明申请MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME AND DATA MANAGEMENT SYSTEMS AND METHODS 有权膜分离装置，系统及其使用方法和数据管理系统及方法公开(公告)号：US20130341291A1
公开(公告)日：2013-12-26
申请号：US14003281
申请日：2012-03-09
IPC分类号： A61M1/34
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译： 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋 这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。
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7.发明申请公开(公告)号：US20120273416A1
公开(公告)日：2012-11-01
申请号：US13095633
申请日：2011-04-27
申请人： Christopher J. Wegener , Marc N. Weasler , Benjamin E. Kusters , Daniel R. Boggs , Kyungyoon Min
发明人： Christopher J. Wegener , Marc N. Weasler , Benjamin E. Kusters , Daniel R. Boggs , Kyungyoon Min
IPC分类号： B01D61/32
CPC分类号： B01D65/02 , A61M1/3496 , B01D61/22 , B01D61/32 , B01D2311/14 , B01D2311/16 , B01D2311/165 , B01D2321/40
摘要： Systems and methods of controlling fouling during a filtration procedure are described. A plasmapheresis method includes accepting a selection of a plasma flow rate and predicting an estimated procedure end time based at least partially on a plasma collection target volume. The method also includes flowing blood past a membrane and changing a plasma flow rate until the selected plasma flow rate through the membrane is achieved. The method also includes determining an acceptable rate of pressure change with time for respective times to the estimated procedure end time, the acceptable fouling rate limit being associated with a system pressure and adjusting the plasma flow rate based on the determined acceptable rate of pressure change with time.
摘要翻译： 描述了在过滤过程中控制结垢的系统和方法。 血浆置换法包括接受血浆流速的选择并且至少部分地基于等离子体收集目标体积来预测估计的过程结束时间。 该方法还包括使血液流过膜并改变等离子体流速，直到达到所选择的通过膜的等离子体流速。 该方法还包括在相应时间内估计可接受的压力变化速率到估计的程序结束时间，可接受的结垢速率极限与系统压力相关联并且基于所确定的可接受的压力变化速率来调节等离子体流速 时间。
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8.发明申请公开(公告)号：US20130345674A1
公开(公告)日：2013-12-26
申请号：US14003284
申请日：2012-03-09
申请人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickhan , Daniel Lynn
发明人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickhan , Daniel Lynn
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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公开(公告)号：US20130341275A1
公开(公告)日：2013-12-26
申请号：US14003298
申请日：2012-03-09
IPC分类号： A61M1/34
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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10.发明授权公开(公告)号：US09656013B2
公开(公告)日：2017-05-23
申请号：US14003290
申请日：2012-03-09
IPC分类号： A61M1/34 , A61M1/14 , A61M1/20 , A61M1/28 , A61M1/02 , A61M1/36 , B01D61/18 , B01D63/06 , B01D63/16 , G06F19/00 , A61M1/38 , A61M1/26
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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