公开(公告)号：US07857768B2

公开(公告)日：2010-12-28

申请号：US12249044

申请日：2008-10-10

申请人： Eric W Starr ,  Bernard F. Hete ,  Eric J Ayers

发明人： Eric W Starr ,  Bernard F. Hete ,  Eric J Ayers

IPC分类号： A61B5/0205 ,  A61B5/1455 ,  A61B5/022

CPC分类号： A61B5/02255 ,  A61B5/14552 ,  A61B2503/40

摘要： An integrated tail mounted blood pressure monitor and pulse oximeter system includes a tail blood flow occlusion member configured to selectively occlude blood flow through the tail; a sensor coupled to the tail blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the tail; a light receiver coupled to the tail and selectively receiving a signal associated with light directed into the tail from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data.

摘要翻译： 综合的尾部安装的血压监测器和脉搏血氧计系统包括构造成选择性地阻塞穿过尾部的血流的尾部血流阻塞构件; 耦合到所述尾部血流阻塞构件的传感器，其检测其操作程度; 耦合到尾部的光源比尾部血流阻塞构件更靠近尾部的远端，并且选择性地将两种不同波长的光引导到尾部中; 耦合到尾部的光接收器并且选择性地接收与从光源引导到尾部中的光相关联的信号; 以及控制器，被配置为从数据中选择性地从数据和脉搏血氧计参数确定血压参数。

公开(公告)号：US20100145170A1

公开(公告)日：2010-06-10

申请号：US12473244

申请日：2009-05-27

申请人： Eric J. Ayers ,  Bernard F. Hete ,  Patrick W. Truitt

发明人： Eric J. Ayers ,  Bernard F. Hete ,  Patrick W. Truitt

IPC分类号： A61B5/1455

CPC分类号： A61B5/02416 ,  A61B5/02405 ,  A61B5/0816 ,  A61B5/1455 ,  A61B5/7203 ,  G16H15/00 ,  G16H40/63

摘要： A user interface for a pulse oximetry device that calculates physiologic parameters of a subject including at least a subject's heart rate and SpO2, is disclosed wherein the interface comprises a graphical display of at least one raw data signal of the pulse oximetry device that maintains heart and breath rate components and a display of the calculated heart rate and SpO2 of the subject. The interface may further include a user selectable data averaging function in which the interface is configured to selectively obtain and display averages of at least some of the calculated physiologic parameters over a defined period. The interface may further include a user selectable noise suppression function for the displayed data.

摘要翻译： 公开了一种用于计算包括至少受试者的心率和SpO2的对象的生理参数的脉搏血氧饱和度测量装置的用户界面，其中所述界面包括维持心脏的脉搏血氧仪装置的至少一个原始数据信号的图形显示， 呼吸速率组分和显示计算的心率和受试者的SpO2。 接口还可以包括用户可选择的数据平均功能，其中接口被配置为在规定的周期内选择性地获得和显示所计算的生理参数中的至少一些的平均值。 接口还可以包括用于所显示的数据的用户可选噪声抑制功能。

公开(公告)号：US20100113902A1

公开(公告)日：2010-05-06

申请号：US12606180

申请日：2009-10-26

申请人： Bernard F. Hete ,  Eric W. Starr ,  Chris Zawada

发明人： Bernard F. Hete ,  Eric W. Starr ,  Chris Zawada

IPC分类号： A61B5/1455 ,  A61B5/055

CPC分类号： G01R33/4808 ,  A61B5/055 ,  A61B5/14552 ,  A61B2503/40

摘要： An efficient, effective, MRI compatible small bore MRI noninvasive photoplethysmographic sensor for animals such as small rodents, namely rats and mice. The photoplethysmographic sensor for animals comprising: a non-magnetic sensor coupling attachable to an animal; fiber optic cable coupled to the sensor coupling and configured to deliver a signal to and receive a signal from the animal tissue adjacent the sensor coupling; an opto-electical converter coupled to the fiber optic cable, the converter including a receiver coupled the fiber optic cable portion configured to receive a signal from the animal tissue and including an emitter coupled to the fiber optic portion configured to deliver a signal to the animal tissue; an electronic coupling extending from the opto-electric converter and configured to be coupled to the emitter and the receiver, wherein the electronic coupling is configured to extend outside of the MRI chamber; and a processor coupled to the electronic coupling.

摘要翻译： 一种高效，有效的MRI兼容小型MRI无创光电体积描记传感器，用于小型啮齿动物，即大鼠和小鼠等动物。 用于动物的光电容积传感器包括：可附接到动物的非磁性传感器耦合器; 光纤电缆耦合到传感器耦合并被配置成将信号传递到邻近传感器耦合器的动物组织并从其接收信号; 耦合到所述光纤电缆的光电转换器，所述转换器包括耦合所述光纤电缆部分的接收器，所述光纤电缆部分被配置为接收来自所述动物组织的信号，并且包括耦合到所述光纤部分的发射器，所述发射器被配置为向所述动物传递信号 组织; 电子耦合器，其从所述光电转换器延伸并且被配置为耦合到所述发射器和所述接收器，其中所述电子耦合器被配置为延伸到所述MRI室外; 以及耦合到电子耦合器的处理器。

公开(公告)号：US08688184B2

公开(公告)日：2014-04-01

申请号：US12330501

申请日：2008-12-08

申请人： Patrick Truitt ,  Bernard F. Hete ,  Eric W Starr

发明人： Patrick Truitt ,  Bernard F. Hete ,  Eric W Starr

IPC分类号： A61B5/00

CPC分类号： A61B5/14552 ,  A61B2503/40

摘要： A noninvasive photoplethysmographic sensor platform for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor platform may be a collar which provides an easily affixed, adjustable attachment mechanism that encircles the animal, such as the neck. The neck of the animal provides several particular advantages as a sensor mounting platform for photoplethysmographic sensors. For pulse oximetry, the neck location will provide significant blood flow under all conditions. For small mammals, such as rats and mice, transmittance pulse oximetry through the neck of the subject remains possible. The neck mounted collar also offers inherent bite resistance to the sensor platform.

摘要翻译： 用于诸如小鼠和小鼠的移动动物的无创光电体积描记传感器平台是有用的，例如在实验室研究环境中。 无创光电体积描记传感器平台可以是一个套环，提供一个环绕动物（如颈部）的容易固定的可调节的附接机构。 作为光电容积传感器的传感器安装平台，动物的颈部提供了几个特殊的优点。 对于脉搏血氧饱和度测量，颈部位置将在所有条件下提供显着的血流量。 对于小型哺乳动物，如大鼠和小鼠，穿过受试者颈部的透射脉搏血氧饱和度仍然是可能的。 颈部安装的衣领还为传感器平台提供了固有的抗咬伤性。

公开(公告)号：US20100160751A1

公开(公告)日：2010-06-24

申请号：US12704024

申请日：2010-02-11

申请人： Bernard F. Hete ,  Eric W. Starr ,  Eric J. Ayers

发明人： Bernard F. Hete ,  Eric W. Starr ,  Eric J. Ayers

IPC分类号： A61B5/1455

CPC分类号： G01N33/4925 ,  A61B5/14557

摘要： A blood oxygenation monitoring device may comprise an extracorporeal pulse simulation system including one at least partially transparent blood holding element with a photoplethysmographic sensor coupled to the element and adapted to measure particular gas content of the blood. The system includes a pulse simulation mechanism configured to simulate pulsatile behavior of the blood within the element relative to the photoplethysmographic sensors. The blood holding element may be a reservoir, wherein the pulse simulation mechanism includes a magnetic stirrer and stir bar within the reservoir. The blood holding member may be flexible tubing having blood flow there through, wherein the pulse simulation mechanism is a peristaltic pump coupled to the tubing. The monitoring device can rapidly and accurately form oxygen dissociation curves. The monitoring device can be utilized in conjunction with a heart lung bypass machine or other extra corporeal circuit devices or can be a calibration tool for sensors.

摘要翻译： 血氧监测装置可以包括体外脉冲模拟系统，其包括一个至少部分透明的血液保持元件，其具有耦合到该元件的光电容积传感器传感器，并且适于测量血液的特定气体含量。 该系统包括脉冲模拟机构，其被配置为模拟元件内相对于光电容积传感器的血液的脉动行为。 血液保持元件可以是储存器，其中脉冲模拟机构包括储存器内的磁力搅拌器和搅拌棒。 血液保持构件可以是具有血液流过的柔性管，其中脉冲模拟机构是联接到管道的蠕动泵。 监测装置可以快速准确地形成氧解离曲线。 监测装置可以与心脏肺旁路机或其他额外的物理电路装置结合使用，或者可以是用于传感器的校准工具。

公开(公告)号：US20090099425A1

公开(公告)日：2009-04-16

申请号：US12249044

申请日：2008-10-10

申请人： Eric W. Starr ,  Bernard F. Hete ,  Eric J. Ayers

发明人： Eric W. Starr ,  Bernard F. Hete ,  Eric J. Ayers

IPC分类号： A61B5/1455 ,  A61B5/0205 ,  A61B5/022

CPC分类号： A61B5/02255 ,  A61B5/14552 ,  A61B2503/40

摘要： An integrated tail mounted blood pressure monitor and pulse oximeter system includes a tail blood flow occlusion member configured to selectively occlude blood flow through the tail; a sensor coupled to the tail blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the tail; a light receiver coupled to the tail and selectively receiving a signal associated with light directed into the tail from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data.

摘要翻译： 综合的尾部安装的血压监测器和脉搏血氧计系统包括构造成选择性地阻塞穿过尾部的血流的尾部血流阻塞构件; 耦合到所述尾部血流阻塞构件的传感器，其检测其操作程度; 耦合到尾部的光源比尾部血流阻塞构件更靠近尾部的远端，并且选择性地将两种不同波长的光引导到尾部中; 耦合到尾部的光接收器并且选择性地接收与从光源引导到尾部中的光相关联的信号; 以及控制器，被配置为从数据中选择性地从数据和脉搏血氧计参数确定血压参数。

公开(公告)号：US20080262326A1

公开(公告)日：2008-10-23

申请号：US12106781

申请日：2008-04-21

申请人： Bernard F. Hete ,  Eric J. Ayers

发明人： Bernard F. Hete ,  Eric J. Ayers

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/02416 ,  A61B5/0816

摘要： A signal processing method of processing a physiologic signal, such as a Photoplethysmography Signal having at least some cardiac components and/or respirator components in the physiologic signal, the processing including the steps of: Identifying a potential cardiac and or respiratory components of a physiologic signal wherein the potential cardiac and or respiratory components have a series of peaks and valleys; Calculating a comparison of the durations of a peak to valley sub-component and a valley to peak sub component of the potential cardiac and or respiratory components; and Utilizing the calculated comparison to evaluate the potential cardiac and or respiratory components.

摘要翻译： 一种处理生理信号的信号处理方法，例如在生理信号中具有至少一些心脏成分和/或呼吸器成分的光电体积描记信号，所述处理包括以下步骤：识别生理信号的潜在心脏和/或呼吸成分 其中所述潜在心脏和/或呼吸成分具有一系列峰和谷; 计算潜在的心脏和/或呼吸成分的峰谷亚组分的持续时间和谷到峰次分量的比较; 并利用计算的比较来评估潜在的心脏和/或呼吸成分。

公开(公告)号：US20080194932A1

公开(公告)日：2008-08-14

申请号：US11972595

申请日：2008-01-10

申请人： Eric J. Ayers ,  Bernard F. Hete ,  Eric W. Starr

发明人： Eric J. Ayers ,  Bernard F. Hete ,  Eric W. Starr

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/0205 ,  A61B5/0816 ,  A61B5/742 ,  A61B2503/40

摘要： A user interface for a pulse oximetry device that calculates physiologic parameters of a subject including at least a subject's heart rate and SpO2, is disclosed wherein the interface comprises a graphical display of at least one raw data signal of the pulse oximetry device that maintains heart and breath rate components and a display of the calculated heart rate and SpO2 of the subject. The interface may further include a user selectable data averaging function in which the interface is configured to selectively obtain and display averages of at least some of the calculated physiologic parameters over a defined period.

摘要翻译： 公开了一种脉搏血氧饱和度测量装置的用户界面，其用于计算包括至少一个对象的心率和主观心理状况的对象的生理参数，其中该界面包括图形 显示维持心脏和呼吸速率分量的脉搏血氧饱和度测量装置的至少一个原始数据信号，并显示所述对象的计算心率和计算心率和S 。 接口还可以包括用户可选择的数据平均功能，其中接口被配置为在规定的周期内选择性地获得和显示所计算的生理参数中的至少一些的平均值。

公开(公告)号：US20080168951A1

公开(公告)日：2008-07-17

申请号：US12013409

申请日：2008-01-11

申请人： Eric W. Starr ,  Patrick W. Truitt ,  Bernard F. Hete

发明人： Eric W. Starr ,  Patrick W. Truitt ,  Bernard F. Hete

IPC分类号： A01K1/06 ,  A61D3/00 ,  A01K29/00

CPC分类号： A01K1/0613 ,  A61D3/00

摘要： A restraining tube for small animals (preferably animals with tails) is designed to facilitate physiologic measurements of the animal through an integrated or associated sensor mount. The physiologic sensors include those for the measurement of pulse oximetry and other measurements such as breath rate, heart rate, pulse distention and breath distention, temperature to name a few. A tail engaging sensor mount geometry is provided for a particular pulse oximeter into the back plate of the tube. The immobility of the animal is especially important given the fact that pulse oximetry measurements are extremely susceptible to even the smallest motion artifact.

摘要翻译： 用于小动物（优选具有尾巴的动物）的限制管被设计成通过集成的或相关联的传感器支架促进动物的生理测量。 生理传感器包括用于测量脉搏血氧饱和度和其他测量的测量，例如呼吸速率，心率，脉搏膨胀和呼吸膨胀，温度等等。 提供尾部接合传感器安装几何形状用于特定的脉搏血氧计进入管的后板。 考虑到脉搏血氧饱和度测量甚至对最小的运动伪影极其敏感，动物的不动性是特别重要的。

公开(公告)号：US20080168948A1

公开(公告)日：2008-07-17

申请号：US12013410

申请日：2008-01-11

申请人： Patrick W. Truitt ,  Bernard F. Hete ,  Eric W. Starr

发明人： Patrick W. Truitt ,  Bernard F. Hete ,  Eric W. Starr

IPC分类号： A01K29/00 ,  A01K1/06 ,  A61D3/00

CPC分类号： A01K1/0613 ,  A61D3/00

摘要： A small animal restraining tube comprises a tube configured to receive a small animal therein; a nosecone within the tube and coupled thereto and configured to abut the animal within the tube to confine the animal on one side of the tube; an endplate coupled to the tube and configured to confine a body portion of the animal on a side opposite the nosecone, whereby the body of the animal is confined within the tube between the nosecone and the endplate, the endplate including an opening there through configured to receive a tail of the animal when the animal is confined within the tube; and a tubular loader mechanism selectively coupled to the tube, wherein the loader mechanism is configured to selectively receive the animal therein and configured to transfer the animal to the retraining tube.

摘要翻译： 小动物限制管包括构造成在其中容纳小动物的管; 管内并且与管连接并配置成邻接管内的动物以将动物限制在管的一侧上; 端板，其耦合到所述管并且被配置为将所述动物的身体部分限制在与所述鼻子相对的一侧上，由此所述动物的身体被限制在所述管中，所述鼻甲和所述端板之间，所述端板包括通过所述开口配置成 当动物被限制在管内时，接收动物的尾巴; 以及选择性地联接到所述管的管状装载机构，其中所述装载机构构造成选择性地接收所述动物并且构造成将所述动物转移到所述再培训管。