公开(公告)号：US08298154B2

公开(公告)日：2012-10-30

申请号：US11972431

申请日：2008-01-10

申请人： Bernard F. Hete ,  Eric J Ayers

发明人： Bernard F. Hete ,  Eric J Ayers

IPC分类号： A61B5/0205

CPC分类号： A61B5/02416 ,  A61B5/02405 ,  A61B5/0816 ,  A61B5/0823 ,  A61B5/1455 ,  A61B5/7207 ,  A61B5/7253 ,  A61B5/7257

摘要： Several techniques are disclosed for isolating either heart or breath rate data from a photoplethysmograph, which is a time domain signal such as from a pulse oximeter. The techniques involve the use of filtering in the frequency domain, after a Fast Fourier Transform (FFT) has been conducted on a given photoplethysmograph also references as a given set of discrete time-domain data. The filtering may be applied to an identified fundamental frequency and one or more harmonics for heart related parameters. The filter may be truncated to the frequency data set and further applied multiple times to improve roll off. After filtering, an Inverse FFT (IFFT) is used to reconstruct the time-domain signal, except with undesirable frequency content eliminated or reduced. Calculation or measurement of parameters is then conducted on this reconstructed time-domain signal.

摘要翻译： 公开了几种用于从例如来自脉搏血氧计的时间域信号的光电体积描记器中分离心脏或呼吸速率数据的技术。 在对给定的光电体积描记仪进行快速傅里叶变换（FFT）之后，技术还涉及在频域中使用滤波，也可以将参考作为一组给定的离散时域数据。 滤波可以应用于所识别的基频和用于心脏相关参数的一个或多个谐波。 滤波器可以被截断为频率数据集，并进一步应用多次以改善滚降。 滤波后，使用逆FFT（IFFT）重建时域信号，除了消除或减少不期望的频率内容。 然后对该重构的时域信号进行参数的计算或测量。

公开(公告)号：US20090223460A1

公开(公告)日：2009-09-10

申请号：US12401572

申请日：2009-03-10

申请人： Eric W. Starr ,  Bernard F. Hete

发明人： Eric W. Starr ,  Bernard F. Hete

IPC分类号： A01K1/03

CPC分类号： A01K1/031 ,  A01K1/0613 ,  A61D7/04

摘要： A hypoxia, or other bioactive gas, chamber is provided for use in animal research conducted on non-anesthetized small animals with direct physiologic monitoring.

摘要翻译： 提供缺氧或其他生物活性气体室用于在具有直接生理监测的非麻醉小动物上进行的动物研究。

公开(公告)号：US20130085354A1

公开(公告)日：2013-04-04

申请号：US13626083

申请日：2012-09-25

申请人： Bernard F. Hete ,  Eric J. Ayers

发明人： Bernard F. Hete ,  Eric J. Ayers

IPC分类号： A61B5/1455 ,  A61B5/0205

CPC分类号： A61B5/14551 ,  A61B5/0205 ,  A61B5/02405 ,  A61B5/02416 ,  A61B5/0816 ,  A61B5/7207 ,  A61B5/7253 ,  A61B5/7257 ,  A61B5/7278

摘要： Several techniques are disclosed for isolating either heart or breath rate data from a photoplethysmograph, which is a time domain signal such as from a pulse oximeter. The techniques involve the use of filtering in the frequency domain, after a Fast Fourier Transform (FFT) has been conducted on a given photoplethysmograph also references as a given set of discrete time-domain data. The filtering may be applied to an identified fundamental frequency and one or more harmonics for heart related parameters. The filter may be truncated to the frequency data set and further applied multiple times to improve roll off. After filtering, an Inverse FFT (IFFT) is used to reconstruct the time-domain signal, except with undesirable frequency content eliminated or reduced. Calculation or measurement of parameters is then conducted on this reconstructed time-domain signal.

摘要翻译： 公开了几种用于从例如来自脉搏血氧计的时间域信号的光电体积描记器中分离心脏或呼吸速率数据的技术。 在对给定的光电体积描记仪进行快速傅里叶变换（FFT）之后，技术还涉及在频域中使用滤波，也可以将参考作为一组给定的离散时域数据。 滤波可以应用于所识别的基频和用于心脏相关参数的一个或多个谐波。 滤波器可以被截断为频率数据集，并进一步应用多次以改善滚降。 滤波后，使用逆FFT（IFFT）重建时域信号，除了消除或减少不期望的频率内容。 然后对该重构的时域信号进行参数的计算或测量。

公开(公告)号：US08359079B2

公开(公告)日：2013-01-22

申请号：US11858879

申请日：2007-09-20

申请人： Bernard F. Hete ,  Eric W Starr ,  Eric J Ayers

发明人： Bernard F. Hete ,  Eric W Starr ,  Eric J Ayers

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/02416 ,  A61B5/0816 ,  A61B5/7257 ,  A61B5/7278 ,  A61B2503/40

摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to a subject. These parameters, together with the conventional physiologic parameters obtained from a pulse oximeter system, can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular applications for animal research.

摘要翻译： 医疗装置和技术从耦合到受试者的脉搏血氧计系统获得受试者的呼吸速率，呼吸膨胀和脉搏扩张测量。 这些参数以及从脉搏血氧计系统获得的常规生理参数可用于帮助控制受试者的通气水平和麻醉水平。 该发展具有人类应用和动物研究的特殊应用。

公开(公告)号：US20120004517A1

公开(公告)日：2012-01-05

申请号：US12980324

申请日：2010-12-28

申请人： Eric W. Starr ,  Bernard F. Hete

发明人： Eric W. Starr ,  Bernard F. Hete

IPC分类号： A61B5/02 ,  A61B5/1455 ,  A61B5/022

CPC分类号： A61B5/02255 ,  A61B5/14552 ,  A61B2503/40

摘要： An integrated blood pressure monitor and pulse oximeter system includes a blood flow occlusion member configured to selectively occlude blood flow through an appendage of the animal (e.g., the neck or tail); a sensor coupled to the blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the appendage; a light receiver coupled to the appendage and selectively receiving a signal associated with light directed into the appendage from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data.

摘要翻译： 综合血压监测器和脉搏血氧计系统包括血液阻塞构件，其构造成选择性地阻塞通过动物的附肢（例如颈部或尾部）的血流; 耦合到所述血流阻塞构件的传感器，其检测其操作程度; 耦合到尾部的光源比尾部血流阻塞构件更靠近尾部远端，并且将两种不同波长的光选择性地引导到附属物中; 耦合到附件的光接收器并且选择性地接收与从光源引导到附属物中的光相关联的信号; 以及控制器，被配置为从数据中选择性地从数据和脉搏血氧计参数确定血压参数。

公开(公告)号：US20110313264A1

公开(公告)日：2011-12-22

申请号：US12968273

申请日：2010-12-14

申请人： Bernard F. Hete

发明人： Bernard F. Hete

IPC分类号： A61B5/1455

CPC分类号： A61B5/0806 ,  A61B5/02416

摘要： A full body plethysmographic chamber includes a noninvasive photoplethysmographic sensor within the chamber. The noninvasive photoplethysmographic sensor is for mobile animals such as small rodents, namely rats and mice in the full body plethysmographic chamber and is useful in a laboratory research environment. The noninvasive photoplethysmographic sensor may be a neck clip or collar which provides an easily affixed attachment mechanism. The neck location will provide significant blood flow under all conditions and also offers inherent bite resistance to the sensor platform. The system of the present invention provides a commutator for the sensor wires for allowing untwisting of the system wires.

摘要翻译： 全身体积描记腔室包括腔内的无创光电体积描记传感器。 无创光电体积描记传感器适用于小型啮齿动物，即全身体积描记腔中的大鼠和小鼠等移动动物，可用于实验室研究环境。 无创光电体积描记传感器可以是提供容易附着的附接机构的颈夹或颈圈。 颈部位置将在所有条件下提供显着的血流量，并且还提供对传感器平台的固有咬合阻力。 本发明的系统提供一种用于传感器线的换向器，用于允许系统线的解捻。

公开(公告)号：US20110137185A1

公开(公告)日：2011-06-09

申请号：US12785421

申请日：2010-05-21

申请人： Bernard F. Hete ,  Eric W. Starr

发明人： Bernard F. Hete ,  Eric W. Starr

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/14552 ,  A61B5/6826 ,  A61B2503/40

摘要： A noninvasive photoplethysmographic sensor platform for small animals provides a spring biased sensor clip, wherein at least one side of the sensor clip is provided with a saddle faced clip face member. The saddle shape of the clip face member may have a hinge end, toward the hinge of the clip, which is longer in the longitudinal direction of the clip and shorter in depth than the distal end. The shorter distal end side (measured longitudinally) of this saddle shape facilitates the ability to align the transmitted and received light with the bone, while the overall saddle shape of the facing provides a physical grip to capture enough tissue to prevent the clip from relocating over time while it is attached to the limb. The shorter hinge end side (depth-wise) also allows the clip to close when it is fully assembled. The edges of the saddle shaped clip are preferably rounded off to prevent the contusions of the tissue that may result from long-term contact. This saddle faced feature works well on only one side of the clip.

摘要翻译： 用于小动物的非侵入式光电容积传感器平台提供弹簧偏置传感器夹，其中传感器夹的至少一侧设置有鞍形面夹具构件。 夹面构件的鞍座形状可以具有朝向夹子的铰链的铰链端，其在夹子的纵向方向上较长并且比远端更深。 这种马鞍形状的较短的远端侧（纵向测量）有助于将透射和接收的光与骨骼对准的能力，而面部的整体鞍座形状提供物理抓地力以捕获足够的组织以防止夹子重新定位在 时间，而它附加到肢体。 较短的铰链端侧（深度方向）也允许夹子完全组装后关闭。 鞍状夹子的边缘优选地倒圆，以防止长期接触可能引起的组织挫伤。 这个马鞍面对的功能只能在剪辑的一侧工作。

公开(公告)号：US07922666B2

公开(公告)日：2011-04-12

申请号：US11858881

申请日：2007-09-20

申请人： Eric W Starr ,  Eric J Ayers ,  Bernard F. Hete

发明人： Eric W Starr ,  Eric J Ayers ,  Bernard F. Hete

IPC分类号： A61B5/0205 ,  A61B5/1455 ,  A61B5/024

CPC分类号： A61B5/02007 ,  A61B5/0205 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/4821 ,  A61B5/7257 ,  A61B5/746 ,  A61B2503/40 ,  A61M16/0051 ,  A61M16/01 ,  A61M16/024

摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to the subject. These parameters together with the conventional physiologic parameters obtained from a pulse oximeter system can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular application for animal research.

摘要翻译： 医疗装置和技术从耦合到受试者的脉搏血氧计系统获得受试者的呼吸速率，呼吸膨胀和脉搏扩张测量。 这些参数与从脉搏血氧计系统获得的常规生理参数一起可用于帮助控制受试者的通气水平和麻醉水平。 该发展具有人类应用和动物研究的特殊应用。

公开(公告)号：US20080295842A1

公开(公告)日：2008-12-04

申请号：US12129643

申请日：2008-05-29

申请人： Bernard F. Hete

发明人： Bernard F. Hete

IPC分类号： A61M16/10 ,  A61M16/20 ,  A62B7/02 ,  A62B9/02

CPC分类号： A61M16/12 ,  A61M2202/0208 ,  A61M2202/0266

摘要： An apparatus for supplying a precise oxygen-nitrogen gas mixture to an animal comprises (i) A source of pressurized oxygen gas, (ii) A source of pressurized nitrogen gas, (iii) A mechanical two-gas blending valve having a first and second gas inlet couplings, and an outlet coupling, the gas blending valve having a manual selector that can incrementally adjust the oxygen-nitrogen gas mixture within a range of mixtures, and a face plate on the blending valve including markings adjacent to the manual selector that are indicative of specific oxygen-nitrogen mixtures, wherein the gas inlets are coupled to the sources of oxygen and nitrogen, respectively, (iv) A gas dispenser coupled to the outlet of the mechanical two gas blending valve; and (v) An animal interface coupling to deliver the gas mixture to the subject animal. The apparatus may be provided for mixtures of air and any gas of interest.

摘要翻译： 用于向动物供应精确的氧 - 氮气体混合物的装置包括（i）加压氧气源，（ii）加压氮气源，（iii）机械二气混合阀，其具有第一和第二 气体入口联接器和出口联接器，气体混合阀具有手动选择器，其可以在混合物范围内逐渐调节氧 - 氮气体混合物，并且混合阀上的面板包括与手动选择器相邻的标记 指示特定的氧 - 氮混合物，其中气体入口分别与氧和氮源连接;（iv）与机械两气体混合阀的出口相连的气体分配器; 和（v）耦合以将气体混合物输送到受试动物的动物界面。 可以为空气和感兴趣的任何气体的混合物提供装置。

公开(公告)号：US20120143071A1

公开(公告)日：2012-06-07

申请号：US13156489

申请日：2011-06-09

申请人： Bernard F. Hete ,  Eric J. Ayers ,  Eric W. Starr

发明人： Bernard F. Hete ,  Eric J. Ayers ,  Eric W. Starr

IPC分类号： A61B5/02

CPC分类号： A61B5/02416 ,  A61B5/7257 ,  A61B2503/40

摘要： A noninvasive photoplethysmographic sensor system for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor for mobile animals such as small rodents utilizes multiple FFT's in the processing of the phtotoplethysmograophic signal, where each FFT has a different time record of the signals such as a number of points, or a zero padded FFTs. The noninvasive photoplethysmographic sensor for mobile animals provides actigraphy measurements for the animal.

摘要翻译： 用于诸如小鼠和小鼠之类的移动动物的无创光电体积描记传感器系统是有用的，例如在实验室研究环境中。 用于诸如小型啮齿动物的移动动物的非侵入性光电容积描记传感器在处理噬菌体同位素信号时利用多个FFT，其中每个FFT具有诸如点数或零填充FFT之类的信号的不同时间记录。 用于移动动物的无创光电体积描记传感器为动物提供了动态测量。