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    SINGLE-CHAIN TNF LIGAND FAMILY MOLECULES AND FUSION PROTEINS AND DERIVATIVES THEREOF
    15.
    发明申请
    SINGLE-CHAIN TNF LIGAND FAMILY MOLECULES AND FUSION PROTEINS AND DERIVATIVES THEREOF 审中-公开

    公开(公告)号：US20180094059A1

    公开(公告)日：2018-04-05

    申请号：US15558372

    申请日：2016-03-18

    Applicant: UNIVERSITÄT STUTTGART ,  BIONTECH AG

    Inventor： Ugur SAHIN ,  Roland KONTERMANN ,  Klaus PFIZENMAIER ,  Martin SIEGEMUND ,  Meike HUTT ,  Oliver SEIFERT

    IPC: C07K16/28 ,  C07K16/32 ,  C07K14/705

    CPC classification number: C07K16/2863 ,  C07K14/70575 ,  C07K16/32 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/91

    Abstract: The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family members (THD) in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof, and a component B comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three THDs in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof. Further, the invention relates to a nucleic acid comprising said polypeptides, a vector comprising said nucleic acid and a pharmaceutical composition comprising said polypeptides, or said nucleic acids or said vector. Further, the present invention relates to said polypeptides, said nucleic acid or said vector for the use as a medicament or for the use in the diagnosis, prophylaxis or treatment of hyperproliferative disorders and inflammatory disorders.

    TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEINS
    19.
    发明申请
    TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEINS 审中-公开
    涉及自身免疫反应的肿瘤疫苗

    公开(公告)号：US20170072035A1

    公开(公告)日：2017-03-16

    申请号：US15341528

    申请日：2016-11-02

    Applicant: BioNTech AG

    Inventor： Thorsten Klamp ,  Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Thomas Hiller ,  Jens Schumacher

    IPC: A61K39/00 ,  C07K14/47 ,  C12N7/00 ,  C07K14/005

    Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

    Abstract translation: 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者内针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者中的自身蛋白质。

    CANNULA, AN INJECTION OR INFUSION DEVICE AND METHODS OF USING THE CANNULA OR THE INJECTION OR INFUSION DEVICE
    20.
    发明申请
    CANNULA, AN INJECTION OR INFUSION DEVICE AND METHODS OF USING THE CANNULA OR THE INJECTION OR INFUSION DEVICE 审中-公开
    肛门，注射或输注装置及使用肛门或注射或输注装置的方法

    公开(公告)号：US20170007776A1

    公开(公告)日：2017-01-12

    申请号：US15115384

    申请日：2014-02-05

    Applicant: BIONTECH AG ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenbert-Univer

    Inventor： Ugur Sahin

    IPC: A61M5/32 ,  A61M5/315

    CPC classification number: A61M5/3291 ,  A61M5/315 ,  A61M5/3286

    Abstract: The present invention provides a cannula (300) with a distal end (311) and a proximal end (312), comprising a sidewall (301) defining a lumen (302) for receiving a fluid (800) from a feeding device (400, 500), wherein the sidewall (301) comprises a plurality of openings (303) for supplying the fluid (800) into a target tissue (700) of a patient. Each opening (304) is in fluid communication with the lumen (302) of the cannula (300). Furthermore, an injection or infusion device (100, 200) is provided, comprising said cannula (300) and a feeding device (400, 500) for supplying the fluid (800) to the cannula (300), wherein the cannula (300) is attached or is configured to be attachable to the feeding device (400, 500). Corresponding methods are also provided, using said cannula and/or said injection or infusion device (100, 200).

    Abstract translation: 本发明提供一种具有远端（311）和近端（312）的插管（300），其包括限定用于从进给装置（400）接收流体（800）的内腔（302）的侧壁（301） 500），其中所述侧壁（301）包括用于将流体（800）供应到患者的靶组织（700）中的多个开口（303）。 每个开口（304）与插管（300）的内腔（302）流体连通。 此外，提供注射或输注装置（100,200），其包括所述插管（300）和用于将流体（800）供应到插管（300）的进给装置（400,500），其中所述插管（300） 被附接或被构造成可附接到所述进给装置（400,500）。 还提供了相应的方法，使用所述套管和/或所述注射或输注装置（100,200）。

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