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公开(公告)号：US11524024B2
公开(公告)日：2022-12-13
申请号：US16890913
申请日：2020-06-02
摘要： This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.
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公开(公告)号：US11519911B2
公开(公告)日：2022-12-06
申请号：US16482216
申请日：2018-01-25
发明人： Bruce Levy , Charles N. Serhan
IPC分类号： G01N33/566
摘要： A method to determine the severity of a disease of chronic inflammation in a patient, comprising the steps of (1) collection or preparation of a bodily fluid, tissue or lavage and (2) measurement of ALX receptor ligands or ALX receptor expression in the fluid, tissue, or lavage, wherein the level of ALX receptor ligands predicts a clinical outcome or choice of treatment modality, is disclosed.
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公开(公告)号：US11504501B2
公开(公告)日：2022-11-22
申请号：US15767846
申请日：2016-10-12
发明人： Takahisa Kato , Nobuhiko Hata
摘要： The disclosure of this application relates generally to medical devices and in particular to a steerable medical instrument applicable to guide interventional tools and instruments, such as percutaneous biopsy and ablations tools and endoscopes. The steerable medical instrument has an outer and an inner tube where the inner tube is movable at the proximal end and fixed at the distal end. At least one of the outer tube and inner tube has a plurality of openings, which creates deformable portions so that the outer and the inner tubes can bend by moving the inner tube at the proximal end.
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14.发明申请公开(公告)号：US20220280114A1
公开(公告)日：2022-09-08
申请号：US17637145
申请日：2020-08-19
发明人： Sharath Krishna Bhagavatula , Kunj Bhaveshkumar Upadhayaya , Alex Andrew Lammers , Oliver Jonas , Devon Michael Thompson
摘要： An anchoring apparatus for a medical microdevice and a method of selectively maintaining the medical microdevice in a predetermined position within a body tissue are provided. The medical microdevice includes a body having longitudinally spaced proximal and distal device ends and a guidewire extending proximally from the proximal device end. The anchoring apparatus includes a selectively expandable anchor having longitudinally spaced proximal and distal anchor ends. A selected one of the proximal and distal anchor ends is connected to the distal or proximal device end, respectively. The anchor self-expands from a collapsed insertion condition to an expanded anchoring condition after insertion into a body tissue to resist post-implantation motion of the microdevice.
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公开(公告)号：US11433094B2
公开(公告)日：2022-09-06
申请号：US17227484
申请日：2021-04-12
IPC分类号： A61K31/737 , A61P3/10 , A61K9/00 , A61K9/107 , A61K47/38
摘要： This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.
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公开(公告)号：US11427869B2
公开(公告)日：2022-08-30
申请号：US15687089
申请日：2017-08-25
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Aviv Regev , Vijay K. Kuchroo , Jellert Gaublomme , Youjin Lee , Chao Wang , Nir Yosef , Hongkun Park , James Kaminski
IPC分类号： C12Q1/6883 , C12Q1/6881 , G01N33/50
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
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公开(公告)号：US20220264020A1
公开(公告)日：2022-08-18
申请号：US17673606
申请日：2022-02-16
发明人： Fumitaro Masaki , Franklin King , Takahisa Kato , Brian Ninni , HuaLei Shelley Zhang , Nobuhiko Hata
IPC分类号： H04N5/232
摘要： An apparatus for correction of a direction to which a tool channel or a camera moves or is bent in a case where a displayed image is rotated. The apparatus includes at least one memory and at least one processor that executes instructions stored in the memory to receive a directional command of a capturing direction of a camera, move the capturing direction of the camera according to the received directional command, detect a rotation amount of a captured image displayed on a monitor, wherein the captured image is captured by the camera, and correct, based on the detected rotation amount, directional information corresponding to a particular directional command or directional coordinate for moving the camera, wherein the directional information is used for moving the capturing direction of the camera.
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公开(公告)号：US20220251651A1
公开(公告)日：2022-08-11
申请号：US15759159
申请日：2016-09-09
IPC分类号： C12Q1/6881 , A61K31/45
摘要： In one aspect, the present invention features method of identifying a cell resistant to a modulator of Cereblon (CRBN). In another aspect, the present invention features a method of characterizing sensitivity of a subject to a modulator of CRBN. In yet another aspect, the present invention features a method of monitoring sensitivity of a subject to a modulator of CRBN.
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公开(公告)号：US11408898B2
公开(公告)日：2022-08-09
申请号：US17215966
申请日：2021-03-29
发明人： Omid Farokhzad , Morteza Mahmoudi , Claudia Corbo
IPC分类号： G01N33/68 , G01N33/543 , G01N33/574 , B82Y35/00 , C01G49/02 , G06K9/00 , G06N20/20 , G06K9/62 , G16B40/20
摘要： The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
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公开(公告)号：US20220238182A1
公开(公告)日：2022-07-28
申请号：US16772747
申请日：2018-12-15
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College
发明人： Max Walt Shen , Jonathan Yee-Ting Flsu , Mandana Arbab , David K. Gifford , David R. Liu , Richard Irving Sherwood
摘要： The specification provides methods for introducing a desired genetic change in a nucleotide sequence using a double-strand break (DSB)-inducing genome editing system, the method comprising: identifying one or more available cut sites in a nucleotide sequence; analyzing the nucleotide sequence and available cut sites with a computational model to identify the optimal cut site for introducing the desired genetic change into the nucleotide sequence; and contacting the nucleotide sequence with a DSB-inducing genome editing system, thereby introducing the desired genetic change in the nucleotide sequence at the cut site.
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