公开(公告)号：US20230363418A1

公开(公告)日：2023-11-16

申请号：US18029234

申请日：2021-09-29

Applicant: CEFO CO., LTD.

Inventor： Yunhee KIM ,  Hyemi LEE ,  Hyockman KWON

IPC: A23K20/147 ,  C12N15/86 ,  A23L33/18 ,  A61K38/18 ,  A61P25/22 ,  A61P25/28

CPC classification number: A23K20/147 ,  A23L33/18 ,  A61K38/185 ,  A61P25/22 ,  A61P25/28 ,  C12N15/86

Abstract: The present invention relates to a composition for preventing or treating neuropsychologic diseases, the composition comprising a mesencephalic growth factor (mesencephalic, astrocyte-derived neurotrophic factor; MANF), a peptide derived therefrom or a fragment thereof. The administration of the MANF according to the present invention promotes the differentiation of cholinergic and/or GABAergic (γ-aminobutyric acid) nerve cells in models of memory impairment and autism to induce nerve regeneration, exhibits the effects of enhancing memory and ameliorating emotional anxiety, and ameliorates social cognition, sociability and decline in social sexual preference, whereby a composition for preventing or treating neuropsychologic diseases such as autism, ADHD, mental retardation disorder, and developmental disorder can be provided.

公开(公告)号：US11802263B2

公开(公告)日：2023-10-31

申请号：US16640849

申请日：2018-08-22

Applicant: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY ,  CEFO CO., LTD. ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Dongmok Lee ,  Woojong Lee ,  Woojin Kim ,  Hyunsook Park ,  Sunray Lee ,  Kiyoung Kim ,  Sungbum Park ,  Kwangrok Kim ,  Byumseok Koh ,  Kyongjin Choi ,  Hyejin Nam ,  Dukjin Kang

IPC: C12M1/32 ,  C12N5/0775

CPC classification number: C12M1/32 ,  C12M23/12 ,  C12N5/0667 ,  C12N2502/1157 ,  C12N2502/1382 ,  C12N2513/00 ,  C12N2533/40

Abstract: The present invention relates to a culture vessel for three-dimensional cell cultivation and a three-dimensional cell co-cultivation method using the same. The culture vessel comprises a well formed by a column positioned thereon and at least one support protruding from the column within the well. In contrast to conventional techniques, the present invention allows cells to be cultured at a position spaced from a culture vessel, thus enjoying the advantage of smoothly supplying oxygen necessary for three-dimensional cell culture structures.

公开(公告)号：US20230248776A1

公开(公告)日：2023-08-10

申请号：US17918093

申请日：2021-10-08

Applicant: CEFO Co., Ltd.

Inventor： Hyun Sook PARK ,  Yeon Kyung LEE ,  Eun Jin GO ,  Ha Jin KIM ,  Sun Ray LEE ,  Ah Reum KWON

IPC: A61K35/32 ,  A61P19/08

CPC classification number: A61K35/32 ,  A61P19/08

Abstract: The present invention relates to a method for differentiating mesenchymal stem cells into osteoblasts, a cell therapeutic agent for treating bone disease including osteoblasts differentiated by the method and a method for producing the same. In addition, the present invention relates to a method for treating bone disease, including the step of administering the osteoblasts obtained by the method to a patient with bone disease.
The differentiation method according to the present invention can stably and rapidly differentiate mesenchymal stem cells into osteoblasts. The differentiated osteoblasts have excellent blood vessel-forming ability and excellent bone-forming ability. Accordingly, the method for differentiating stem cells into osteoblasts and the osteoblasts obtained by the method, according to the present invention, can be effectively used as a cell therapeutic agent or treatment method related to bone disease.

公开(公告)号：US20230172190A1

公开(公告)日：2023-06-08

申请号：US18011133

申请日：2021-06-14

Applicant: CEFO Co., Ltd.

Inventor： Hyun Sook PARK ,  Sunray LEE

IPC: A01N1/02 ,  B01L3/00

CPC classification number: A01N1/0252 ,  B01L3/50853 ,  B01L3/50857

Abstract: The present invention relates to a cell cryopreservation device, and can comprise: a first housing for accommodating a plurality of test tubes; a second housing for covering the first housing; center support ribs extended upward from the inner bottom surface of the first housing to come in contact with and support the side surfaces of the surrounding test tubes; and side support ribs extended from the inner wall surface of the first housing toward the inner side of the first housing to come in contact with and support the side surfaces of the test tubes.

公开(公告)号：US20170283768A1

公开(公告)日：2017-10-05

申请号：US15512455

申请日：2015-09-15

Applicant: CEFO CO., LTD

Inventor： Hyun Sook PARK ,  Sun Ray LEE ,  Ji Won YANG ,  Seol CHU ,  Hyun Jung MO

IPC: C12N5/00 ,  C12N5/0775 ,  C12N5/073

CPC classification number: C12N5/0068 ,  C12M3/00 ,  C12M25/14 ,  C12N5/00 ,  C12N5/0603 ,  C12N5/0663 ,  C12N5/0667 ,  C12N5/0668 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2537/10

Abstract: The present invention relates to a method for inducing osteogenic differentiation of mesenchymal stem cells and, more particularly, to a short-time osteogenic differentiation method of culturing cells using a porous membrane and a biodegradable synthetic biogel, whereby the cells do not contact a cell culture container. The present invention can significantly shorten the induction period of osteogenic differentiation, compared to the conventional osteogenic differentiation method, and has an effect of the cells being easily separable after differentiation as well.