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公开(公告)号:US20230020133A1
公开(公告)日:2023-01-19
申请号:US17756734
申请日:2020-12-04
Applicant: VitreaLab GmbH , CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Jonas ZEUNER , Chiara GREGANTI , Roberto OSELLAME
IPC: F21V8/00
Abstract: An optical device for controlling light from an external light source including: at least a first and a second waveguide for guiding a light beam emitted from the external light source; and at least a first beam shaping structure with a first light emitting area for emitting a light beam and a second beam shaping structure with a second light emitting area for emitting a light beam, wherein the first waveguide guides the light beam emitted from the external light source to the first beam shaping structure and the second waveguide guides the light beam emitted from the external light source to the second beam shaping structure; wherein the first and the second beam shaping structure-are each configured such that the uniformity of the radiant density profile of a light beam emitted from the respective light emitting area of the respective beam shaping structure is higher than that of the light beam guided to the respective beam shaping structure by the respective waveguide. Backlight unit including such an optical device; and optical system, in particular holographic display, including such a backlight unit and a spatial light modulator.
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公开(公告)号:US20220380766A1
公开(公告)日:2022-12-01
申请号:US17413550
申请日:2019-12-16
Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM AKA , Consiglio Nazionale delle Ricerche
Inventor: Gabriel LOPEZ-BERESTEIN , Paola AMERO , Cristian RODRIGUEZ-AGUAYO , Rahul MITRA , Anil K. SOOD , Vittorio DE FRANCISCIS , David VOLK , Lokesh Ganesh L. RAO
IPC: C12N15/115 , A61K31/337 , A61K33/243 , A61P35/00
Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.
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公开(公告)号:US20220291311A1
公开(公告)日:2022-09-15
申请号:US17629137
申请日:2020-07-21
Inventor: Carlo RIZZA , Angelo GALANTE , Marco FANTASIA , Marcello ALECCI
IPC: G01R33/36 , A61B5/055 , G01R33/341 , G01R33/60
Abstract: An apparatus for increasing efficiency in the transmission phase and sensitivity in the reception phase, in specific regions of space, of magnetic resonance imaging technique by using at least one metamaterial or dielectric material is provided. Placing the metamaterial or dielectric material in a suitable geometry, in the space delimited by an RF coil and a sample, allows using the surface plasmonic resonances or equivalent dielectric resonances, induced in the metamaterial or dielectric material by the RF coil, to amplify the intensity of the magnetic field in the spatial region of the sample, improving the intensity of the signal transmission and/or the sensitivity of detection. The metamaterial or dielectric material is positioned outside the RF coil to maximize the amplification effect.
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公开(公告)号:US11408632B2
公开(公告)日:2022-08-09
申请号:US16618358
申请日:2018-05-30
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Ottaviano Allegretti , Paolo Dionisi Vici
IPC: F24F11/84 , F24F5/00 , F24F6/02 , F24F11/00 , F24F110/22 , F24F110/12
Abstract: A climate generator adapted to produce a flow of air at controlled temperature and at relative humidity values (tc, ic) is described, which includes a bubbler (100) which receives a flow of air to be conditioned (Ga), heat exchangers (120) associated with the bubbler (100) to adjust the temperature of the water volume (W) of the bubbler and/or to provide an amount of latent heat of evaporation to the aforesaid volume of water (W); and heaters (180) for heating the flow of air at the dew point (Gb) exiting from the bubbler (100) to the controlled temperature value of the flow of air, wherein the temperature of the volume of water (W) is established as a function of the controlled temperature and relative humidity values (tc, ic), so that the heating of the flow of air at the dew point (Gb) from the temperature of the water volume (W) to the controlled temperature value determines a decrease in the relative humidity (ic) of the flow of air to the controlled relative humidity value.
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公开(公告)号:US20220064090A1
公开(公告)日:2022-03-03
申请号:US17371941
申请日:2021-07-09
Applicant: Consiglio Nazionale delle Ricerche , Università degli Studi di Modena e Reggio Emilia , Mediteknology S.r.l. , Sapienza Università di Roma
Inventor: Pasquale Linciano , Cinzia Citti , Fabiana Russo , Livio Luongo , Monica Iannotta , Carmela Belardo , Sabatino Maione , Maria Angela Vandelli , Flavio Forni , Giuseppe Gigli , Aldo Laganá , Anna Laura Capriotti , Carmela Maria Montone , Giuseppe Cannazza
IPC: C07C37/11 , C07D311/94
Abstract: The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical compositions and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.
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公开(公告)号:US20210402374A1
公开(公告)日:2021-12-30
申请号:US17292596
申请日:2019-09-30
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE , MEDICA S.P.A.
Inventor: Manuela Melucci , Vincenzo Palermo , Massimo Zambianchi , Andrea Liscio , Alessandro Kovtun , Emanuele Treossi , Luisa Maria Navacchia , Letizia Bocchi
Abstract: A method for the treatment of a substrate; the substrate comprises hollow fibre membranes, each of which has a side wall, comprising a base material, and an inner lumen, which is delimited by the side wall; the base material comprises a polysulfone or a derivative thereof; the substrate is placed in contact with graphene oxide in the presence of a liquid so as to obtain an intermediate compound, from which the liquid is at least partially removed and which is thermally treated so that the graphene oxide is at least partially fixed to the substrate and a treated material is obtained comprising treated fibres.
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公开(公告)号:US20210371595A1
公开(公告)日:2021-12-02
申请号:US17052881
申请日:2019-05-10
Applicant: ENI S.P.A. , CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Alberto Renato De Angelis , Laura Boggioni , Simona Losio
Abstract: Elastomeric copolymer with a high sulfur content, comprising sulfur in a quantity higher than or equal to 40% by weight, preferably ranging from 55% by weight to 90% by weight, with respect to the total weight of said elastomeric copolymer, and at least one monomer having general formula (I): CH2═CH—(CH2)y-(X)n-(X)m-(CH2)x—CH═CH2 (I) wherein: X represents a sulfur atom, a selenium atom, a tellurium atom, preferably a sulfur atom, a selenium atom; y and x, equal to or different from one another, are a whole number ranging from 0 to 4; n and m, equal to or different from one another, are a whole number ranging from 0 to 3, at least one of n and m being equal to 1; said monomer being present in a quantity lower than or equal to 60% by weight, preferably ranging from 10% by weight to 45% by weight, with respect to the total weight of said elastomeric copolymer; provided that, in the case wherein in said general formula (I) X is sulfur, y and x are 1, at least one of n and m must be different from 1 and the sum of n+m must be different from 1. Said elastomeric copolymer with a high sulfur content can be advantageously used in a great many applications such as, for example, thermal insulation, conveyor
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公开(公告)号:US20210147395A1
公开(公告)日:2021-05-20
申请号:US17045028
申请日:2019-04-02
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE , MOLIPHARMA S.R.L.
Inventor: Maria Cristina DE ROSA , Davide PIROLLI , Giovanni SCAMBIA , Daniela GALLO , Marco PETRILLO , Marta DE DONATO , Benedetta RIGHINO
IPC: C07D405/06 , C07D471/04
Abstract: The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.
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公开(公告)号:US10895528B2
公开(公告)日:2021-01-19
申请号:US15765029
申请日:2016-09-30
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE—CNR
Inventor: Davide Mazzotti , Pablo Cancio Pastor , Iacopo Galli , Paolo De Natale , Giovanni Giusfredi
IPC: G01N21/3504 , G01J3/42 , G01N21/39
Abstract: The present invention is relative to a method of ring-down spectroscopy in saturated-absorption condition, for measuring a first concentration of a gas through a measurement of the spectrum of a molecular transition of said gas.
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公开(公告)号:US10520425B2
公开(公告)日:2019-12-31
申请号:US15763742
申请日:2016-09-27
Applicant: POLITECNICO DI MILANO , CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Andrea Bassi , Petra Paiè , Roberto Osellame , Francesca Bragheri
Abstract: An integrated optofluidic device to illuminate, along an irradiation direction, a fluidic sample containing an object to be analysed, the device comprising: a substrate comprising an entry surface and being made of a material transparent to a light beam incident through the entry surface along the irradiation direction; a microfluidic channel formed in the substrate and having a channel portion intercepting the irradiation direction and extending along a longitudinal axis transverse to the irradiation direction, the microfluidic channel comprising a first flow inlet port for loading a fluidic sample therein, and an elongated lens cavity for an optofluidic cylindrical lens, the cavity being formed in the substrate and being arranged along the beam irradiation direction between the entry surface and the microfluidic channel, wherein the lens cavity is in fluid communication with a lens inlet port for loading a lens fluid.
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