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公开(公告)号：US5892001A
公开(公告)日：1999-04-06
申请号：US725969
申请日：1996-10-04
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
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公开(公告)号：US5552303A
公开(公告)日：1996-09-03
申请号：US31399
申请日：1993-03-08
申请人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
CPC分类号： C07K14/5443 , A61K38/00 , C07K2319/02
摘要： There is disclosed a mammalian epithelium-derived T-cell factor (EFT) polypeptide, derivatives thereof, DNA sequences, recombinant DNA molecules and transformed host cells that produce ETF polypeptides. More particularly, this invention provides isolated mammalian ETF polypeptides and derivatives thereof that regulate events in T-lymphocyte proliferation.
摘要翻译： 公开了哺乳动物上皮衍生的T细胞因子（EFT）多肽，其衍生物，DNA序列，重组DNA分子和产生ETF多肽的转化的宿主细胞。 更具体地，本发明提供分离的哺乳动物ETF多肽及其衍生物，其调节T淋巴细胞增殖中的事件。
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公开(公告)号：US20100015137A1
公开(公告)日：2010-01-21
申请号：US12343429
申请日：2008-12-23
申请人： Charles Rauch , Henning Walczak
发明人： Charles Rauch , Henning Walczak
IPC分类号： A61K39/395
CPC分类号： C07K14/70578 , A61K38/00 , C07K1/22 , C07K14/715
摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.
摘要翻译： 称为TRAIL受体的蛋白质结合称为TNF相关凋亡诱导配体（TRAIL）的蛋白质。 TRAIL受体可用于纯化TRAIL或抑制其活性。 提供了编码TRAIL-R多肽的分离的DNA序列，以及含有DNA序列的表达载体和用这些重组表达载体转化的宿主细胞。 还提供了与TRAIL-R免疫反应的抗体。
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公开(公告)号：US07528239B1
公开(公告)日：2009-05-05
申请号：US09378045
申请日：1999-08-20
申请人： Charles Rauch , Henning Walczak
发明人： Charles Rauch , Henning Walczak
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K14/70578 , A61K38/00 , C07K1/22 , C07K14/715
摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.
摘要翻译： 称为TRAIL受体的蛋白质结合称为TNF相关凋亡诱导配体（TRAIL）的蛋白质。 TRAIL受体可用于纯化TRAIL或抑制其活性。 提供了编码TRAIL-R多肽的分离的DNA序列，以及含有DNA序列的表达载体，以及用这些重组表达载体转化的宿主细胞。 还提供了与TRAIL-R免疫反应的抗体。
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公开(公告)号：US06569642B1
公开(公告)日：2003-05-27
申请号：US09536201
申请日：2000-03-27
申请人： Charles Rauch , Henning Walczak
发明人： Charles Rauch , Henning Walczak
IPC分类号： C07H2104
CPC分类号： C07K16/2878 , A61K38/00 , C07K14/70578 , C07K14/715 , C07K2317/34
摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.
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公开(公告)号：US06406877B2
公开(公告)日：2002-06-18
申请号：US09727169
申请日：2000-11-29
IPC分类号： C12Q137
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将来自26kD细胞形式的TNF-α转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US07695948B2
公开(公告)日：2010-04-13
申请号：US11709436
申请日：2007-02-21
IPC分类号： C12N9/48
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 将TNF-α从26kD细胞形式转化为17kD形式的金属蛋白酶已被分离并纯化，cDNA序列已知。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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18.发明授权Method of treating cancer by administering an epithelum-derived T-cell factor 失效通过施用上皮衍生的T细胞因子治疗癌症的方法公开(公告)号：US07625553B2
公开(公告)日：2009-12-01
申请号：US11704726
申请日：2007-02-09
CPC分类号： C07K14/5443 , A61K38/00
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
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公开(公告)号：US07199224B2
公开(公告)日：2007-04-03
申请号：US10423729
申请日：2003-04-25
申请人： Roy A Black , Charles Rauch , Carl J March , Douglas P Cerretti
发明人： Roy A Black , Charles Rauch , Carl J March , Douglas P Cerretti
IPC分类号： C07K16/00
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将来自26kD细胞形式的TNF-α转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US06642358B1
公开(公告)日：2003-11-04
申请号：US09578392
申请日：2000-05-25
申请人： Charles Rauch , Henning Walczak
发明人： Charles Rauch , Henning Walczak
IPC分类号： C07K1400
CPC分类号： C07K16/2878 , A61K38/00 , C07K14/70578 , C07K14/715 , C07K2317/34
摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.
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