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公开(公告)号：US20070072172A1
公开(公告)日：2007-03-29
申请号：US11600796
申请日：2006-11-17
Applicant: Mei-Chih Wang , Chin-Yu Lin , Hui-Ti Lin
Inventor： Mei-Chih Wang , Chin-Yu Lin , Hui-Ti Lin
CPC classification number: G01N33/5067 , C12N15/85 , C12N2830/008 , C12N2830/85 , G01N2800/52
Abstract: The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer 5 flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific lineages, such as liver cells, from other cell lineages.
Abstract translation: 本发明涉及具有肝细胞特异性的嵌合调节序列。 嵌合调节序列包括近端调节序列和人甲胎蛋白（AFP）基因的侧翼区域的远端增强子5。 嵌合调节序列可用于来自其他细胞谱系的纯化特异谱系，如肝细胞。
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Patent Agency Ranking
公开(公告)号：US20050158852A1
公开(公告)日：2005-07-21
申请号：US11008929
申请日：2004-12-13
Applicant: Mei-Chih Wang , Mei-Hwei Fan-Chiang , Hui-Ti Lin , Chin-Yu Lin
Inventor： Mei-Chih Wang , Mei-Hwei Fan-Chiang , Hui-Ti Lin , Chin-Yu Lin
IPC: C12N5/0735 , C12N5/08
CPC classification number: C12N5/0606 , C12N2501/70 , C12N2502/13 , C12N2502/1323 , C12N2510/00 , C12N2533/50 , C12N2533/52 , C12N2533/54
Abstract: The present invention discloses a method for improving growth and survival of single human embryonic stem cells. The method includes the step of obtaining a single undifferentiated HES cell; mixing the single undifferentiated cell with an extracellular matrix (ECM) to encompass the cell; and inoculating the mixture onto feeder cells with a nutrient medium in a growth environment. Therefore the single cells can survive, proliferate and grow in vitro.
Abstract translation: 本发明公开了一种改善单人胚胎干细胞生长和存活的方法。 该方法包括获得单个未分化HES细胞的步骤; 将单个未分化细胞与细胞外基质（ECM）混合以包围细胞; 并在生长环境中用营养培养基将混合物接种到饲养细胞上。 因此，单细胞可以在体外存活，增殖和生长。
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公开(公告)号：US20110245103A1
公开(公告)日：2011-10-06
申请号：US13151116
申请日：2011-06-01
Applicant: Lukas C. Amler , Merrill Birkner , Chin-Yu Lin , Joachim Moecks , Andreas Strauss
Inventor： Lukas C. Amler , Merrill Birkner , Chin-Yu Lin , Joachim Moecks , Andreas Strauss
IPC: C40B30/04
CPC classification number: C12Q1/6886 , A61K39/39558 , B65B61/20 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/57407 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/57449 , G06Q99/00 , A61K2300/00
Abstract: The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab.It also describes the use of high HER2:HER3 ratio as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a HER inhibitor, such as pertuzumab.In addition, the application describes the use of high HER3 as a selection criterion for treating cancer patients with a chemotherapeutic agent, for instance gemcitabine.
Abstract translation: 本申请描述了使用低HER3作为治疗患有HER抑制剂的患者的选择标准，例如珀妥珠单抗。 它还描述了使用高HER2：HER3比例作为治疗癌症患者（如卵巢癌患者）的选择标准，其具有HER抑制剂如妥他珠单抗。 此外，本申请描述了使用高HER3作为治疗癌症患者与化疗剂例如吉西他滨的选择标准。
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公开(公告)号：US07972851B2
公开(公告)日：2011-07-05
申请号：US11600796
申请日：2006-11-17
Applicant: Mei-Chih Wang , Chin-Yu Lin , Hui-Ti Lin
Inventor： Mei-Chih Wang , Chin-Yu Lin , Hui-Ti Lin
CPC classification number: G01N33/5067 , C12N15/85 , C12N2830/008 , C12N2830/85 , G01N2800/52
Abstract: The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer 5′ flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific lineages, such as liver cells, from other cell lineages.
Abstract translation: 本发明涉及具有肝细胞特异性的嵌合调节序列。 嵌合调节序列包括近端调节序列和人甲胎蛋白（AFP）基因的远侧增强子5'侧翼区域。 嵌合调节序列可用于来自其他细胞谱系的纯化特异谱系，如肝细胞。
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公开(公告)号：US20090007937A1
公开(公告)日：2009-01-08
申请号：US12104685
申请日：2008-04-17
Applicant: Chung-Nun Chen , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-chih Wu
Inventor： Chung-Nun Chen , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-chih Wu
IPC: B08B3/04
CPC classification number: B08B3/102 , B01L3/502 , B01L2300/045 , B01L2300/046 , B01L2300/0681 , B01L2300/0832 , B01L2400/0478 , C12M47/12
Abstract: In a general aspect, an apparatus for washing biological material is provided which includes an outer sleeve, and an inner sleeve disposed within the outer sleeve. The outer sleeve has an open end for receiving the biological material, and an opposed closed end. The inner sleeve is detachably and slidably positioned within the outer sleeve, and includes a first port for receiving and dispensing washing liquid, a second port defining a liquid flow path between an interior of the inner sleeve and an interior of the outer sleeve, and a filter disposed in the second port. The filter allows passage of washing liquid but not passage of the biological material therethrough. A chamber, formed between the filter and the closed end of the outer sleeve, is configured to permit flow of washing liquid via the filter while retaining the biological material therein.
Abstract translation: 在一般方面，提供了一种用于洗涤生物材料的装置，其包括外套筒和设置在外套筒内的内套筒。 外套筒具有用于接收生物材料的开口端和相对的封闭端。 所述内套筒可拆卸地且可滑动地定位在所述外套筒内，并且包括用于接收和分配洗涤液体的第一端口，限定所述内套筒的内部和所述外套筒的内部之间的液体流路的第二端口，以及 过滤器设置在第二端口中。 过滤器允许洗涤液体通过，但不允许生物材料通过。 形成在过滤器和外套管的封闭端之间的室被构造成允许经由过滤器流动清洗液体，同时将生物材料保持在其中。
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公开(公告)号：US20060068370A1
公开(公告)日：2006-03-30
申请号：US11030110
申请日：2005-01-07
Applicant: Mei-Chih Wang , Chin-Yu Lin , Hui-Ti Lin , Mei-Hwei Fan-Chiang
Inventor： Mei-Chih Wang , Chin-Yu Lin , Hui-Ti Lin , Mei-Hwei Fan-Chiang
CPC classification number: G01N33/5067 , C12N15/85 , C12N2830/008 , C12N2830/85 , G01N2800/52
Abstract: The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer of 5′ flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific cell lineages, such as liver cells, from other cell lineages.
Abstract translation: 本发明涉及具有肝细胞特异性的嵌合调节序列。 嵌合调节序列包括近端调节序列和人甲胎蛋白（AFP）基因的5'侧翼区的远端增强子。 嵌合调节序列可用于来自其他细胞谱系的纯化特异性细胞谱系，例如肝细胞。
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