公开(公告)号：US20120003234A1

公开(公告)日：2012-01-05

申请号：US13140467

申请日：2009-12-21

Applicant: John Allan Hamilton ,  Andrew David Cook

Inventor： John Allan Hamilton ,  Andrew David Cook

IPC: A61K39/395 ,  A61P19/02

CPC classification number: C07K16/2866 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/243 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.

Abstract translation: 本发明一般涉及治疗和/或预防骨关节炎（OA）的方法。 根据本发明，GM-CSF拮抗剂可有效治疗骨关节炎。 GM-CSF的拮抗剂包括但不限于对GM-CSF或GM-CSF受体特异的抗体。 本发明还提供了可用于在某些疾病模型中测试拮抗剂的转基因动物，例如GM-CSF敲除小鼠。

公开(公告)号：US07703292B2

公开(公告)日：2010-04-27

申请号：US11495281

申请日：2006-07-28

Applicant: David Cook ,  Ramesh Janardhanam ,  Natarajan Venkatakrishnan

Inventor： David Cook ,  Ramesh Janardhanam ,  Natarajan Venkatakrishnan

IPC: F25C1/00 ,  G05D23/32

CPC classification number: F25C1/04 ,  F25B2600/112 ,  F25C2400/10 ,  F25C2600/04

Abstract: A refrigerator includes a housing defining a freezer storage compartment, an evaporator operatively coupled to the freezer storage compartment and configured to cool the freezer storage compartment, and an evaporator fan positioned to move air across the evaporator. The refrigerator also includes an ice maker positioned within the freezer storage compartment, a dispenser in flow communication with the ice maker and configured to dispense ice, and a control system configured to receive a signal from said dispenser indicating dispensing of a first amount of ice from the dispenser, the control system configured to activate the evaporator fan in response to the signal, the evaporator fan operating continuously for a time period upon activation.

Abstract translation: 冰箱包括限定冷冻库储存室的壳体，可操作地联接到冷冻库储存室并构造成冷却冷藏库储存室的蒸发器和定位成使空气移动通过蒸发器的蒸发器风扇。 冰箱还包括位于冷藏库储存室内的制冰机，与制冰机流体连通并配置成分配冰的分配器，以及配置成从所述分配器接收来自所述分配器的信号的控制系统，其指示从第 所述分配器，所述控制系统被配置为响应于所述信号而激活所述蒸发器风扇，所述蒸发器风扇在激活时持续一段时间。

公开(公告)号：US20080272094A9

公开(公告)日：2008-11-06

申请号：US11468393

申请日：2006-08-30

Applicant: Jonathan Mather ,  David Cook ,  David Bouthillier ,  John Sobr ,  Stephen Eickhoff

Inventor： Jonathan Mather ,  David Cook ,  David Bouthillier ,  John Sobr ,  Stephen Eickhoff

IPC: B23K9/00

CPC classification number: H05H1/34 ,  H05H2001/3442

Abstract: An improved electrode for use in a plasma arc torch. The electrode includes an electrode body, a bore defined by and disposed in the electrode body, and an insert disposed in the bore. The insert and/or the bore of the electrode are configured to improve retention of the insert in the electrode, thereby extending electrode life. The invention also includes a method for forming the electrode. The method includes a step of positioning an insert into a bore of an electrode such that an exterior gap is established that is greater than a second gap.

Abstract translation: 一种用于等离子弧焊炬的改进电极。 电极包括电极体，由电极主体限定和设置的孔，以及设置在孔中的插入件。 电极的插入物和/或孔被配置为改善插入物在电极中的保持性，从而延长电极寿命。 本发明还包括一种形成电极的方法。 该方法包括将插入件定位到电极的孔中以使得建立大于第二间隙的外部间隙的步骤。

公开(公告)号：US07429986B2

公开(公告)日：2008-09-30

申请号：US11081320

申请日：2005-03-16

Applicant: Adityo Prakash ,  Eniko Fodor ,  Edward Ratner ,  David Cook

Inventor： Adityo Prakash ,  Eniko Fodor ,  Edward Ratner ,  David Cook

IPC: G06T15/00

CPC classification number: G06T7/579

Abstract: In one embodiment according to the present invention, relative z-ordering of segments in a digital image is determined. A method comprises forward and backward motion matching of image regions to determine overlap, followed by the creation of relationships (e.g., pairwise relationships) between regions and comparing the result with the original image to determine the relative z-ordering.

Abstract translation: 在根据本发明的一个实施例中，确定数字图像中段的相对z-排列。 一种方法包括图像区域的向前和向后运动匹配以确定重叠，随后在区域之间建立关系（例如，成对关系），并将结果与​​原始图像进行比较以确定相对z排序。

公开(公告)号：US07364444B2

公开(公告)日：2008-04-29

申请号：US10571541

申请日：2004-09-10

Applicant: Andrew Kellock ,  Quentin David Cook

Inventor： Andrew Kellock ,  Quentin David Cook

IPC: H01R13/44

CPC classification number: H01R13/4536 ,  H01R24/64

Abstract: A shuttered electrical connector for receiving an electrical plug, the plug having a hinged tail for lockingly engaging with the connector, is disclosed. The connector includes: a body 20 defining a socket having 22 an open mouth 24; a central shutter 30 hingedly mounted to the body 20 adjacent the open mouth 24 for rotation about a first hinge axis 32; and a pair of spaced apart side shutters 40 & 50 hingedly mounted to the body 20 adjacent the open mouth 24 for rotation about a second hinge axis 42, the second hinge axis 42 parallel to and spaced apart from the first hinge axis 32. The shutters are rotatable through approximately 90 degrees from: a closed position in which together they cover the open mouth 24 while presenting a substantially flat outer face, to an open position receiving the plug in which the central shutter is offset from the side shutters.

Abstract translation: 公开了一种用于接收电插头的闭合电连接器，该插头具有用于与连接器锁定接合的铰接尾部。 连接器包括：主体20，其限定具有开口24的插座22; 中央快门30，其铰接地安装到邻近开口24的主体20上，以围绕第一铰链轴线32旋转; 以及一对间隔开的侧面快门40和50，其铰接地安装到邻近开口24的本体20上，用于围绕第二铰链轴线42旋转，第二铰链轴线42平行于第一铰链轴线32并与第一铰链轴线32间隔开。 百叶窗可以从关闭位置旋转大约90度，在该关闭位置中，它们一起覆盖开口24，同时呈现基本上平坦的外表面，到达接收塞子的打开位置，中央快门偏离侧挡板。

公开(公告)号：US20080026034A1

公开(公告)日：2008-01-31

申请号：US11493324

申请日：2006-07-26

Applicant: David Cook ,  Robert Falotico ,  Lily Kuo ,  Jonathon Z. Zhao

Inventor： David Cook ,  Robert Falotico ,  Lily Kuo ,  Jonathon Z. Zhao

IPC: A61F2/02 ,  A61K31/4745

CPC classification number: A61L31/10 ,  A61F2/07 ,  A61F2/91 ,  A61F2/95 ,  A61F2/954 ,  A61F2002/065 ,  A61F2002/075 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606

Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque. Implantable coated medical devices may be processed through annealing to better control the elution characteristics of the therapeutic agents. Furthermore, annealing leads to better therapeutic agent stability and a larger device shelf-life.

Abstract translation: 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。 药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。 可以通过退火处理可植入的涂覆的医疗装置，以更好地控制治疗剂的洗脱特性。 此外，退火导致更好的治疗剂稳定性和更大的器件保质期。

公开(公告)号：US07296610B2

公开(公告)日：2007-11-20

申请号：US10800544

申请日：2004-03-15

Applicant: Matthew Zaluzec ,  David Cook ,  Ulrich Weiss ,  Maik Broda ,  Clemens Verpoort

Inventor： Matthew Zaluzec ,  David Cook ,  Ulrich Weiss ,  Maik Broda ,  Clemens Verpoort

IPC: B22D19/04 ,  B22D19/08

CPC classification number: B22D19/0009 ,  B22D19/0081 ,  B22D19/08 ,  C23C2/02 ,  C23C4/18 ,  C23C6/00 ,  F01L3/04 ,  F01L2101/00 ,  F01L2103/00 ,  Y10T29/49231 ,  Y10T29/49984

Abstract: A method of manufacturing metallic components consisting of at least two different materials, one of them being an iron-based alloy and the other an aluminum-based alloy, and involving the steps of: depositing a metallic layer onto the body made from the iron-based alloy, said layer being an aluminum-based alloy, preferably based on Al—Si or Fe, placing the coated body in a casting mold and casting an aluminum-based alloy about the coated body. Prior to placing the body in the casting mold, the metallic layer of the body is sprayed and/or blasted with silicon powder and/or Borax (Na2B4O7—10H2O, hydrated sodium borate).

Abstract translation: 一种制造由至少两种不同材料组成的金属组件的方法，其中一种是铁基合金，另一种是铝基合金，包括以下步骤：将金属层沉积在由铁 - 所述层是铝基合金，优选基于Al-Si或Fe，将涂覆体放置在铸模中并且在涂覆体周围浇铸铝基合金。 在将本体放置在铸模中之前，用硅粉和/或硼砂（Na 2 B 4 O 4）喷射和/或喷射身体的金属层， N 2，水合硼酸钠）。

公开(公告)号：US20060262576A1

公开(公告)日：2006-11-23

申请号：US11392953

申请日：2006-03-30

Applicant: Jan Przybyla ,  Jonathan Clare ,  David Cook ,  Patrick Wheeler ,  Maurizio Catucci

Inventor： Jan Przybyla ,  Jonathan Clare ,  David Cook ,  Patrick Wheeler ,  Maurizio Catucci

IPC: H02M3/335

CPC classification number: H02M7/219 ,  Y02B70/1441

Abstract: An AC to DC converter comprises a bi-directional switch array converter which converts a three phase AC supply at 50/60 Hz to a high frequency single phase drive for a series resonant parallel loaded tank. The tank is transformer coupled to a rectifier and filter to give a high voltage isolated DC supply to drive a load. The switching of the converter is based on control of the resonant tank to operate as close to a desired tank reference voltage as possible.

Abstract translation: AC到DC转换器包括双向开关阵列转换器，其将50 / 60Hz的三相AC电源转换成用于串联谐振并联负载箱的高频单相驱动。 油箱是变压器连接到整流器和过滤器，以提供高压隔离的直流电源来驱动负载。 转换器的切换是基于谐振槽的控制，以尽可能接近所需的储罐参考电压来工作。

公开(公告)号：US07136841B2

公开(公告)日：2006-11-14

申请号：US10994973

申请日：2004-11-23

Applicant: David Cook

Inventor： David Cook

IPC: G06Q99/00

CPC classification number: G06Q20/04 ,  G06Q20/027 ,  G06Q20/085 ,  G06Q20/0855 ,  G06Q20/108 ,  G06Q20/12 ,  G06Q20/3674 ,  G06Q20/382 ,  G06Q20/3821 ,  G06Q20/3825 ,  G06Q20/383 ,  G06Q20/40 ,  G06Q20/401 ,  G06Q20/4012 ,  G06Q20/4016

Abstract: A system and method for authorizing certain aspects of network based transactions between a customer and a merchant is disclosed. At a credit card authorization system, merchant information, transaction information, and a credit card number of a customer is received from an e-commerce merchant. An authorization form at the credit card authorization system that contains the transaction information is created. An internet browser associated with the customer is caused to display the authorization form. A signature phrase is received from the customer via the authorization form. The received signature phrase is verified that it corresponds to a signature phrase stored in a credit card account associated with the credit card number. The internet browser associated with the customer is caused to be transferred to a web site associated with the e-commerce merchant.

Abstract translation: 公开了一种用于授权客户和商家之间基于网络的交易的某些方面的系统和方法。 在信用卡授权系统中，从电子商务商家接收到顾客的商家信息，交易信息和信用卡号。 创建包含交易信息的信用卡授权系统的授权表单。 导致与客户相关联的互联网浏览器显示授权表单。 从客户通过授权表收到签名短语。 验证所接收的签名短语，其对应于存储在与信用卡号码相关联的信用卡帐户中的签名短语。 将与客户相关联的互联网浏览器转移到与电子商务商家相关联的网站。

公开(公告)号：US20060159095A1

公开(公告)日：2006-07-20

申请号：US11036728

申请日：2005-01-14

Applicant: David Cook ,  Russell White ,  Alvaro Retana

Inventor： David Cook ,  Russell White ,  Alvaro Retana

IPC: H04L12/28

CPC classification number: H04L45/586 ,  H04L45/04 ,  H04L45/46

Abstract: A method and apparatus are presented for determining network nodes for aggregating addresses in routing information used for routing data packets over a network. Link data and reachability data are received. Link data indicates direct links between each of multiple candidate routers of a network and a different router or a network segment. Reachability data indicates a set of one or more contiguous network addresses that can be reached on each link described in the link data. A measure of possible aggregation of contiguous network addresses is determined at the candidate routers based on the link data and the reachability data. A preferred router to aggregate addresses in routing information sent between routers in the network is determined among the candidate routers based on the measure of possible aggregation at each candidate router.

Abstract translation: 提出了一种方法和装置，用于确定网络节点，用于聚合用于通过网络路由数据分组的路由信息​​中的地址。 接收到链接数据和可达性数据。 链路数据表示网络的多个候选路由器和不同路由器或网段之间的每个候选路由器之间的直接链路。 可达性数据表示在链接数据中描述的每个链路上可以达到的一组或多个连续网络地址的集合。 基于链路数据和可达性数据，在候选路由器处确定连续网络地址的可能聚合的度量。 基于每个候选路由器可能聚合的测量，在候选路由器之间确定在网络中的路由器之间发送的路由信息​​中聚合地址的优选路由器。