Abstract:
This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T—R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
Abstract translation:本发明描述了式IV的新型吡唑化合物:其中环D是5-7元单环或选自芳基,杂芳基,杂环基或碳环基的8-10元双环; R x和R y独立地选自T-R 3,或与它们的插入原子一起形成具有1-3个选自氧,硫或氮的环杂原子的稠合的,不饱和的或部分不饱和的5-8元环; R2,R2',T和R3如说明书中所述。 这些化合物可用作蛋白激酶抑制剂,特别是作为用于治疗诸如癌症,糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。
Abstract:
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
Abstract:
The invention provides a process for selecting and ordering one or more sets of linguistic objects. The invention orders a current list of items for selection that comprises a first list of one or more items of a first language and a second list of one or more items of a second language, the current list of items being displayed in an order based on the first language having a priority over the second language. In response to a user selection of one item from the second list, the invention changes a priority for ordering a subsequent list of items to order the subsequent list of items based on the second language having a priority over the first language.
Abstract:
A housing for animal feedstuff including a base, a roof extending over the base, uprights spaced apart from one another and extending between the base and the roof, and a container locatable between the uprights for containing feedstuff. Livestock, such as cattle, access feedstuff within the container by way of spaces between the uprights. In an embodiment, the uprights are telescopic and the roof can be pivoted between raised and lowered positions relative to the uprights.
Abstract:
There is disclosed an enhanced text entry system which uses word-level analysis to automatically correct inaccuracies in user keystroke entries on reduced keyboards such as those implemented on a touch-sensitive panel or display screen, or on mechanical keyboard systems. A method and system are defined which determine one or more alternate textual interpretations of each sequence of inputs detected within a designated auto-correcting keyboard region. The actual contact locations for the keystrokes may occur outside the boundaries of the specific keyboard key regions associated with the actual characters of the word interpretations proposed or offered for selection, where the distance from each contact location to each corresponding intended character may in general increase with the expected frequency of the intended word in the language or in a particular context. Likewise, in a mechanical keyboard system, the keys actuated may differ from the keys actually associated with the letters of the word interpretations. Each such sequence corresponds to a complete word, and the user can easily select the intended word from among the generated interpretations. Additionally, when the system cannot identify a sufficient number of likely word interpretation candidates of the same length as the input sequence, candidates are identified whose initial letters correspond to a likely interpretation of the input sequence. The approach utilizes the information contained in the entire sequence of keystrokes corresponding to a word in order to determine the user's likely intention for each character of the sequence. The system also accommodates punctuation characters such as hyphens or apostrophes that are commonly embedded in words such as hyphenated compounds and contractions in English, and characters with special diacritics such as are commonly found in various European languages, e.g., diacritic accent. Special functions may be applied depending on where the user touches the intended string in a displayed word selection list. Once the user selects the desired string, it is automatically “accepted” for output and the next input detected starts a new input sequence corresponding to the entry of a next word.
Abstract:
An adapter and method for through the lens (TTL) laser range sensor probes enables use of a TTL probe of a given exit pupil size to be used with a shared objective lens requiring a entrance pupil size, as entered from the laser range sensor, that is different from the TTL probe exit pupil size. Embodiments of the adapter include optics, such as a first lens and a resolving second lens that expand or contract the TTL laser radiation depending on whether the first lens is a diverging, a negative focal length lens, or a converging, positive focal length lens, and the second lens is converging or diverging, respectively, in a Galilean arrangement. Embodiments also provide a Keplerian arrangement, can function with non-collimated radiation, and can include mirrors to yield a more compact adapter. Additional embodiments include at least one adjustable lens element between the first and second lenses, the at least one adjustable lens element being connected to an actuator for movement along the optical path. The adapter can be arranged in a folded configuration in which mirrors are used to form a more compact adapter.
Abstract:
An orthopedic screw having a torque driving head with a rounded side a spherical wall for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4 to about 12° and the major diameter of the screw remaining substantially the same meaning that the major diameter is constant to about +/−0.05 mm along the length of the threaded portion. The screw includes a multilobe torque driving recess joined to a cylindrical recess. In a further embodiment, the screw has an insertion tip which is forms a portion of a sphere.
Abstract:
From a text entry tool, a digital data processing device receives inherently ambiguous user input. Independent of any other user input, the device interprets the received user input against a vocabulary to yield candidates such as words (of which the user input forms the entire word or part such as a root, stem, syllable, affix), or phrases having the user input as one word. The device displays the candidates and applies speech recognition to spoken user input. If the recognized speech comprises one of the candidates, that candidate is selected. If the recognized speech forms an extension of a candidate, the extended candidate is selected. If the recognized speech comprises other input, various other actions are taken.
Abstract:
This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
Abstract:
A hybrid approach to improve handwriting recognition and voice recognition in data process systems is disclosed. In one embodiment, a front end is used to recognize strokes, characters and/or phonemes. The front end returns candidates with relative or absolute probabilities of matching to the input. Based on linguistic characteristics of the language, e.g. alphabetical or ideographic language for the words being entered, e.g. frequency of words and phrases being used, likely part of speech of the word entered, the morphology of the language, or the context in which the word is entered), a back end combines the candidates determined by the front end from inputs for words to match with known words and the probabilities of the use of such words in the current context.