公开(公告)号：US20050250178A1

公开(公告)日：2005-11-10

申请号：US10614599

申请日：2003-07-07

Applicant: David Andrew ,  David Lewin ,  Diane Pennica ,  Luca Rastelli ,  Bruce Tallion

Inventor： David Andrew ,  David Lewin ,  Diane Pennica ,  Luca Rastelli ,  Bruce Tallion

IPC: A61K38/00 ,  C07K14/52 ,  C12N1/21 ,  C12N15/19 ,  C07H21/04 ,  C07K14/705 ,  C07K16/28

CPC classification number: C07K14/52 ,  A61K38/00

Abstract: The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.

Abstract translation: 本发明提供了称为FCTRX多肽的新型多肽，以及编码FCTRX多肽的多核苷酸和免疫特异性结合FCTRX或FCTRX多肽，多核苷酸或抗体的衍生物，变体，突变体或片段的抗体。 本发明还提供了FCTRX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US20210073739A1

公开(公告)日：2021-03-11

申请号：US16948172

申请日：2020-09-06

Applicant: Benjamin Kwitek ,  David Lewin

Inventor： Benjamin Kwitek ,  David Lewin

IPC: G06Q10/10 ,  G06Q10/06

Abstract: A method for workforce talent, tracking and development, that uses a computer for sending information to each of a plurality of applicants for a job. The computer gets information from people making recommendations about whether to hire the applicants. It sends information to the applicants indicating whether or not they have been selected for the job, including an accepted applicant for the job, and multiple other applicants who were not accepted for the job; and after a job has been accepted, using the computer for tracking multiple applicants including at least the accepted applicant for the job, and multiple of the other applicants.

公开(公告)号：US08152327B2

公开(公告)日：2012-04-10

申请号：US12572910

申请日：2009-10-02

Applicant: David C. Brands ,  R. Stephen Mulder ,  David Lewin

Inventor： David C. Brands ,  R. Stephen Mulder ,  David Lewin

IPC: F21L4/00 ,  G02B5/04

CPC classification number: F21L4/027 ,  F21V5/006 ,  F21V5/04 ,  F21V7/0091 ,  F21V14/06 ,  F21V14/065 ,  F21Y2115/10 ,  G02B19/0028 ,  G02B19/0061 ,  Y10S362/80

Abstract: A lens for a flashlight or other lighting unit provides for focusing light from a source, such as an LED, to provide a light beam adjustable between a spot beam and a wide beam. The lens includes a lens body with a front face, a rear LED-receiving well, and a side surface extending between the front face and the rear well. The front face includes a central surface surrounded by an annular concave surface. The rear well includes a space for the LED to be adjusted in position. The rear well space is defined by a concavely-curved sidewall and a concavely-curved base. The concave curvature of the sidewall and base may be Bezier curves.

Abstract translation: 用于手电筒或其他照明单元的透镜提供聚焦来自诸如LED的源的光，以提供在点光束和宽光束之间可调节的光束。 透镜包括具有前表面的透镜体，后LED接收孔以及在前表面和后孔之间延伸的侧表面。 前表面包括由环形凹面包围的中心表面。 后井包括用于将LED调节到适当位置的空间。 后井空间由凹曲面的侧壁和凹弯曲的基部限定。 侧壁和底座的凹曲率可以是贝塞尔曲线。

公开(公告)号：US20070015700A1

公开(公告)日：2007-01-18

申请号：US11333773

申请日：2006-01-17

Applicant: David Lewin ,  Timothy Stewart

Inventor： David Lewin ,  Timothy Stewart

IPC: A01K67/027 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC classification number: C12N9/1205 ,  C07K14/575

Abstract: Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity.

Abstract translation: 公开了在进食和空腹循环期间差异调节的基因。 这些基因及其编码的多肽可用于抵抗肥胖症。

公开(公告)号：US20060294612A1

公开(公告)日：2006-12-28

申请号：US11278477

申请日：2006-04-03

Applicant: David Lewin ,  Timothy Stewart

Inventor： David Lewin ,  Timothy Stewart

IPC: C12Q1/68 ,  G01N33/567 ,  A01K67/027 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/72 ,  C07K16/28

CPC classification number: C07K14/5759 ,  A61K38/00 ,  C07K14/705

Abstract: A novel G-protein coupled receptor-like retinoic acid induced molecule was identified as being differentially expressed (GPCR-like RAIG1) in an animal model of fasting and feeding. Compositions and methods pertaining to treatment and diagnosis of various metabolic disorders, such as cachexia and obesity.

Abstract translation: 在禁食和喂食的动物模型中，鉴定出新型G蛋白偶联受体样视黄酸诱导分子为差异表达（GPCR样RAIG1）。 关于治疗和诊断各种代谢疾病如恶病质和肥胖症的组合物和方法。

公开(公告)号：US20050074767A1

公开(公告)日：2005-04-07

申请号：US10608865

申请日：2003-06-27

Applicant: David Lewin ,  Timothy Stewart

Inventor： David Lewin ,  Timothy Stewart

IPC: C12N15/09 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P3/04 ,  C07K14/00 ,  C07K14/47 ,  C07K14/575 ,  C07K14/665 ,  C07K14/805 ,  C07K16/18 ,  C12M1/00 ,  C12M1/34 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12Q1/02 ,  C12Q1/68

CPC classification number: C07K14/665 ,  A61K38/00 ,  A61K2123/00 ,  C07K14/57554 ,  C07K14/5759 ,  C07K14/805 ,  C12N9/6424 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y304/21094

Abstract: The instant invention is concerned with genes associated with obesity. Additionally, the invention provides methods of using the differential expression of these genes associated with obesity to diagnose and treat obesity, as well as to screen for compounds useful for treating obesity.

Abstract translation: 本发明涉及与肥胖相关的基因。 另外，本发明提供了使用与肥胖相关的这些基因的差异表达来诊断和治疗肥胖症以及筛选可用于治疗肥胖症的化合物的方法。