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11.发明申请Small molecule modulators of hepatocyte growth factor (scatter factor) activity 有权肝细胞生长因子（分散因子）活性的小分子调节剂公开(公告)号：US20050192331A1
公开(公告)日：2005-09-01
申请号：US11025373
申请日：2004-12-29
Applicant: David Zembower , David Eiznhamer
Inventor： David Zembower , David Eiznhamer
IPC: A61K31/4155 , C07D231/12 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , A61K31/416 , C07D43/02 , C07D45/02 , C07D49/02
CPC classification number: C07D231/12 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14
Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
Abstract translation: 本发明提供具有式（I）的化合物及其药学上可接受的衍生物，其中R 1，R 2和B如本文中所述的类别和亚类所述， 并且还提供其药物组合物及其用于治疗其中HGF / SF或其活性或其激动剂或拮抗剂具有治疗有用作用的许多病症或疾病中的任何一种的方法。
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12.发明授权公开(公告)号：US07714017B2
公开(公告)日：2010-05-11
申请号：US11247431
申请日：2005-10-11
Applicant: Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Mikhaylovich Polozov , Wayne Edward Zeller
Inventor： Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Mikhaylovich Polozov , Wayne Edward Zeller
IPC: A61K31/403 , A61K31/404 , A61K31/405 , C07D209/02 , C07D209/04 , A61K31/19 , A61K31/192 , C07C61/12
CPC classification number: C07D263/58 , C07D209/08 , C07D209/12 , C07D209/34 , C07D235/06 , C07D487/04 , C07D513/04
Abstract: Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:
Abstract translation: 公开了用于治疗或预防前列腺素介导的疾病或病症的环取代的稠合双环羧酸。 化合物具有通式A的代表性实例是：
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公开(公告)号：US20090291948A1
公开(公告)日：2009-11-26
申请号：US12534390
申请日：2009-08-03
Applicant: Jasbir Singh , Mark E. Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou
Inventor： Jasbir Singh , Mark E. Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou
IPC: A61K31/538 , C07D403/02 , A61K31/4162 , G01N33/566 , C07D513/04 , C07D487/02 , A61K31/429 , A61K31/4188 , A61K31/47 , C07D215/02 , C07D215/227 , C07D265/36 , C07D209/04 , A61K31/405 , A61P29/00 , A61P9/10
CPC classification number: C07D263/58 , C07D209/12 , C07D209/30 , C07D209/34 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:
Abstract translation: 公开了用于治疗或预防前列腺素介导的疾病或病症的酰基磺酰胺，邻位取代的稠合双环化合物。 化合物具有通式A的代表性实例是：
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14.发明授权公开(公告)号：US07598397B2
公开(公告)日：2009-10-06
申请号：US11169161
申请日：2005-06-27
Applicant: Jasbir Singh , Mark E. Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou
Inventor： Jasbir Singh , Mark E. Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou
IPC: C07D411/00
CPC classification number: C07D263/58 , C07D209/12 , C07D209/30 , C07D209/34 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:
Abstract translation: 公开了用于治疗或预防前列腺素介导的疾病或病症的酰基磺酰胺，邻位取代的稠合双环化合物。 化合物具有通式A的代表性实例是：
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Patent Agency Ranking
公开(公告)号：US20070213319A1
公开(公告)日：2007-09-13
申请号：US11651927
申请日：2007-01-10
Applicant: David Zembower , Jasbir Singh , Rama Mishra , Dawoon Jung , Xiaokang Zhu
Inventor： David Zembower , Jasbir Singh , Rama Mishra , Dawoon Jung , Xiaokang Zhu
IPC: A61K31/55 , A61K31/5377 , A61K31/517 , C07D413/02 , C07D405/02 , C07D403/02
CPC classification number: C07D239/95 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D409/12 , C07D413/04
Abstract: This invention is directed to compounds and compositions that have biological properties useful for modulating HGF/SF activity. In certain embodiments, said compounds and compositions may be used in the treatment and prophylaxis of cancer or other dysproliferative diseases, as well as inflammatory diseases such as rheumatoid arthritis.
Abstract translation: 本发明涉及具有可用于调节HGF / SF活性的生物学特性的化合物和组合物。 在某些实施方案中，所述化合物和组合物可用于治疗和预防癌症或其它增生性疾病，以及炎性疾病如类风湿性关节炎。
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16.发明申请公开(公告)号：US20060142355A1
公开(公告)日：2006-06-29
申请号：US11247431
申请日：2005-10-11
Applicant: Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Polozov , Wayne Zeller
Inventor： Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Polozov , Wayne Zeller
IPC: A61K31/43 , A61K31/4188 , A61K31/4162 , C07D498/02 , C07D487/02
CPC classification number: C07D263/58 , C07D209/08 , C07D209/12 , C07D209/34 , C07D235/06 , C07D487/04 , C07D513/04
Abstract: Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:
Abstract translation: 公开了用于治疗或预防前列腺素介导的疾病或病症的环取代的稠合双环羧酸。 化合物具有通式A的代表性实例是：
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17.发明申请Small molecule modulators of hepatocyte growth factor (scatter factor) activity 有权肝细胞生长因子（分散因子）活性的小分子调节剂公开(公告)号：US20050113369A1
公开(公告)日：2005-05-26
申请号：US11024615
申请日：2004-12-29
Applicant: David Zembower , David Eiznhamer
Inventor： David Zembower , David Eiznhamer
IPC: A61K31/4155 , C07D231/12 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , A61K31/541 , A61K31/416 , A61K31/4439 , A61K31/496 , A61K31/5377
CPC classification number: C07D231/12 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14
Abstract: The present invention provides compounds having formula (1): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
Abstract translation: 本发明提供具有式（1）的化合物及其药学上可接受的衍生物，其中R 1，R 2和B如本文中所述的类别和亚类所述， 并且还提供其药物组合物及其用于治疗其中HGF / SF或其活性或其激动剂或拮抗剂具有治疗有用作用的许多病症或疾病中的任何一种的方法。
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公开(公告)号：US5977385A
公开(公告)日：1999-11-02
申请号：US115984
申请日：1998-07-15
Applicant: Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
Inventor： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
IPC: A61K45/06 , C07D311/16 , C07D493/04 , C07D493/14 , C07D493/00
CPC classification number: C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
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公开(公告)号：US5859050A
公开(公告)日：1999-01-12
申请号：US926307
申请日：1997-09-05
Applicant: Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Lin Lin
Inventor： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Lin Lin
IPC: A61K45/06 , C07D311/16 , C07D493/04 , C07D493/14 , A61K31/35
CPC classification number: C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
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