公开(公告)号：USD585280S1

公开(公告)日：2009-01-27

申请号：US29266561

申请日：2006-09-25

Applicant: Iain Charles Edward Stuart

Designer： Iain Charles Edward Stuart

公开(公告)号：US20080187573A1

公开(公告)日：2008-08-07

申请号：US11850141

申请日：2007-09-05

Applicant: Francesca Mary Brewer ,  Edward Stuart Johnson ,  Anthony Clarke

Inventor： Francesca Mary Brewer ,  Edward Stuart Johnson ,  Anthony Clarke

IPC: A61K31/131 ,  A61K9/00

CPC classification number: A61K31/137 ,  A61K9/0056 ,  A61K9/2095 ,  A61K31/136

Abstract: A fast dispersing solid pharmaceutical composition having a monoamine oxidase B inhibitor as the only active ingredient is disclosed for the treatment of Parkinson's disease. The composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membranes, such that at least 5% of the active ingredient is absorbed in one minute, as determined by a buccal absorption test.

Abstract translation: 公开了具有单胺氧化酶B抑制剂作为唯一活性成分的快速分散固体药物组合物用于治疗帕金森病。 将组合物配制成促进通过颊，舌下，咽和/或食管粘膜的吸收，使得至少5％的活性成分在一分钟内被吸收，如通过口腔吸收试验测定的。

公开(公告)号：US09668804B2

公开(公告)日：2017-06-06

申请号：US13676082

申请日：2012-11-13

Applicant: Suhasa Bangalore Kodandaramaiah ,  Edward Stuart Boyden ,  Crag Richard Forest ,  Brian Yichiun Chow ,  Giovanni Talei Franzesi

Inventor： Suhasa Bangalore Kodandaramaiah ,  Edward Stuart Boyden ,  Crag Richard Forest ,  Brian Yichiun Chow ,  Giovanni Talei Franzesi

IPC: A61B5/053 ,  A61B34/30 ,  A61B18/14 ,  A61B5/00 ,  A61B5/04

CPC classification number: A61B18/14 ,  A61B5/04001 ,  A61B5/0538 ,  A61B5/6885 ,  A61B34/30 ,  A61B2503/40

Abstract: In an automated methodology for carrying out in vivo cell patch clamping, a cell patch clamping device is automatically moved into position and targeted to a neuron. Neuron contact is determined by analyzing the temporal series of measured resistance levels at the cell patch clamping device as it is moved. The difference between successive resistance levels is computed and compared to a threshold, which must be exceeded for a minimum number of computations before neuron contact is assumed. Pneumatic control methods are used to achieve gigaseal formation and cell break-in, leading to whole-cell patch clamp formation. An automated robotic system capable of performing this methodology automatically performs patch clamping in vivo, automatically detecting cells by analyzing the temporal sequence of electrode impedance changes. By continuously monitoring the patching process and rapidly executing actions triggered by specific measurements, the robot can rapidly find neurons in the living brain and establish recordings.

公开(公告)号：US20160000590A1

公开(公告)日：2016-01-07

申请号：US14681076

申请日：2015-04-07

Applicant: Edward Stuart Boyden ,  Giovanni Talei Franzesi ,  Christian Wentz ,  Nir Grossman ,  Elazer R. Edelman ,  Colin Derdeyn ,  Eric Leuthardt

Inventor： Edward Stuart Boyden ,  Giovanni Talei Franzesi ,  Christian Wentz ,  Nir Grossman ,  Elazer R. Edelman ,  Colin Derdeyn ,  Eric Leuthardt

IPC: A61F2/90 ,  A61B5/07 ,  A61B5/00 ,  A61N2/02 ,  A61B5/04

CPC classification number: A61F2/90 ,  A61B5/026 ,  A61B5/04 ,  A61B5/076 ,  A61B5/686 ,  A61B5/6862 ,  A61F2/82 ,  A61F2230/0069 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36117 ,  A61N1/375 ,  A61N1/3787 ,  A61N2/02

Abstract: An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. The device includes an internal skeleton, a flexible substrate attached to the exterior of the skeleton, at least one pair of electrodes located on the substrate, and power and control circuitry connected to the electrodes. The power and control circuitry may include connectors for direct powering of the electrodes or circuit elements for wireless powering of the device by RF-based, optical-based, ultrasound-based, piezoelectric, or vibrational energy harvesting methods. The power and control circuitry may include circuit elements for wireless communication, including between the device and the external environment, and may include on-board processing for control of the electrodes.

Abstract translation: 电子血管内装置被放置成与血管壁紧密接触并且用于血管壁和周围靶组织的电刺激和/或电记录。 电极可以通过将它们连接到外部硬件的连接器进行操作，或者可以结合电子器件以允许无线电力，信息传输和控制。 该装置包括内部骨架，附接到骨架外部的柔性基底，位于基底上的至少一对电极以及连接到电极的电力和控制电路。 功率和控制电路可以包括用于直接为电极或电路元件供电的连接器，用于通过基于RF的，基于光学的，基于超声的，压电的或振动能量收集方法来无线供电设备。 功率和控制电路可以包括用于无线通信的电路元件，包括在设备和外部环境之间，并且可以包括用于控制电极的板载处理。

公开(公告)号：US20140228857A1

公开(公告)日：2014-08-14

申请号：US14079630

申请日：2013-11-13

Applicant: Suhasa Bangalore Kodandaramaiah ,  Edward Stuart Boyden ,  Craig Richard Forest

Inventor： Suhasa Bangalore Kodandaramaiah ,  Edward Stuart Boyden ,  Craig Richard Forest

IPC: A61B19/00

CPC classification number: A61B34/30 ,  A61B5/04001 ,  A61B5/0538 ,  A61B5/6885 ,  A61B34/32 ,  A61B2503/40

Abstract: In an automated method for in vivo multiple cell patch clamping, cell patch clamping devices are automatically moved into position and targeted to multiple corresponding cells. Cell contact is determined by analyzing the temporal series of measured resistance levels at the clamping devices as they are moved. The difference between successive resistance levels is computed and compared to a threshold, which must be exceeded for a minimum number of computations before neuron contact is assumed. Pneumatic control methods are used to achieve cell-attached or gigaseal formation and subsequent cell break-in, leading to whole-cell patch clamp formation. An automated robotic system automatically performs patch clamping in vivo, automatically detecting cells according to the methodology by analyzing the temporal sequence of electrode impedance changes. By continuously monitoring the patching process and rapidly executing actions triggered by specific measurements, the robot can rapidly find neurons in the living brain and establish recordings.

Abstract translation: 在用于体内多细胞膜片钳夹的自动化方法中，细胞膜片夹紧装置被自动移动到位并被靶向多个相应的细胞。 通过分析夹持装置移动时的测量电阻值的时间序列来确定电池触点。 计算连续电阻水平之间的差异，并与阈值进行比较，阈值在假设神经元接触之前必须超过最小计算次数。 气动控制方法用于实现细胞附着或基因组形成和随后的细胞破裂，导致全细胞膜片钳形成。 自动机器人系统在体内自动执行贴片钳制，通过分析电极阻抗变化的时间序列，根据方法自动检测细胞。 通过持续监测修补过程并快速执行由特定测量触发的动作，机器人可以快速发现活体大脑中的神经元并建立记录。

公开(公告)号：US08767984B2

公开(公告)日：2014-07-01

申请号：US12746357

申请日：2008-12-08

Applicant: Edward Stuart Fletcher

Inventor： Edward Stuart Fletcher

IPC: H04R5/02

CPC classification number: H04R5/02 ,  H04R1/24 ,  H04R1/2842 ,  H04R1/323 ,  H04R2205/022

Abstract: Apparatus for reproduction of stereo sound from a two channel signal, having one or more first transducers (3a, 3b) for reproducing a signal comprising one of or the sum of the two channels, and one or more second transducers (5) for reproducing a signal comprising the difference between the two channels. The apparatus is arranged such that the signal generated by the one or more first transducers (3a, 3b) is transmitted from an output plane in a direction substantially orthogonal to the output plane. The apparatus also has a duct (6) associated with the one or more second transducers (5) and is arranged to conduct the signal generated by the one or more second transducers (5) such that it is transmitted along a direction substantially parallel to the output plane from a point spaced from the plane in the direction in which the signal generated by the one or more first transducers (3a, 3b) is transmitted.

Abstract translation: 用于从双通道信号再现立体声的装置，具有一个或多个第一换能器（3a，3b），用于再现包括两个通道中的一个或两个通道之一的信号;以及一个或多个第二换能器（5），用于再现 信号包括两个通道之间的差异。 该装置被布置为使得由一个或多个第一换能器（3a，3b）产生的信号从输出平面沿大致正交于输出平面的方向传送。 该设备还具有与一个或多个第二换能器（5）相关联的管道（6），并且布置成传导由一个或多个第二换能器（5）产生的信号，使得其沿着基本上平行于 输出平面从与由所述一个或多个第一换能器（3a，3b）产生的信号的方向相对的平面间隔开的点。

公开(公告)号：US08553914B2

公开(公告)日：2013-10-08

申请号：US12440017

申请日：2007-08-21

Applicant: Edward Stuart Fletcher

Inventor： Edward Stuart Fletcher

IPC: H04R5/02

CPC classification number: H04R5/02 ,  H04R1/2819 ,  H04R2499/15 ,  H04S1/002

Abstract: Apparatus for reproducing stereo sound having a housing (1, 25) defining an at least partially enclosed space. A first transducer (7) or pair of transducers (28, 29) is provided and arranged to reproduce one, both or the sum of two audio signals. A pair of transducers (10, 32) is also provided and arranged to reproduce a signal comprising the difference of the two audio signals. As the transducers communicate with the at least partially enclosed space, and the transducers arranged to reproduce the difference between the two audio signals are each arranged to direct their output primarily in a direction generally at right angles to the direction in which the first transducer or pair of transducers primarily direct their output. The apparatus may be arranged to be placed on or adjacent a generally flat surface, and the transducers arranged to reproduce the difference of the two audio signals may be arranged to direct their output towards the flat surface.

Abstract translation: 用于再现具有限定至少部分封闭空间的外壳（1,25）的立体声的装置。 第一传感器（7）或一对换能器（28,29）被提供并布置成再现两个或两个音频信号之和。 还提供一对换能器（10,32）并且被布置成再现包括两个音频信号的差异的信号。 当换能器与至少部分封闭的空间通信时，布置成再现两个音频信号之间的差异的换能器各自被布置成主要在与第一换能器或对的方向大致成直角的方向上引导它们的输出 传感器主要指导其输出。 该装置可以被布置成放置在大致平坦的表面上或附近，并且布置成再现两个音频信号的差异的换能器可以被布置成将其输出引导到平坦表面。

公开(公告)号：US08391516B2

公开(公告)日：2013-03-05

申请号：US12733238

申请日：2008-08-14

Applicant: Edward Stuart Fletcher

Inventor： Edward Stuart Fletcher

IPC: H04R25/00

CPC classification number: H04R1/26 ,  H04R1/025 ,  H04R5/023 ,  H04R2201/023

Abstract: A method of using an audio device (2) for improving a user's (1) listening experience. The audio device has a transducer (12) for producing output sound and the method comprises the steps of driving the transducer to produce an output sound and placing the audio device against the body of the user so that the user experiences a physical response to the sound while simultaneously listening to the audio device. The audio device may be arranged to produce a resonance in a part of the user's body. Preferably the audio device is positioned on the user's chest to produce a resonance in the chest cavity of the user's body. The audio device may comprise a sum and difference speaker system.

Abstract translation: 一种使用音频设备（2）来改善用户（1）听觉体验的方法。 音频设备具有用于产生输出声音的换能器（12），并且该方法包括以下步骤：驱动换能器以产生输出声音，并将音频设备放置在使用者的身体上，使得用户体验对声音的物理响应 同时收听音频设备。 音频设备可以被布置成在用户身体的一部分中产生谐振。 优选地，音频设备定位在用户的胸部上以在用户身体的胸腔中产生共振。 音频设备可以包括总和和差分扬声器系统。

公开(公告)号：US07917927B1

公开(公告)日：2011-03-29

申请号：US09868254

申请日：1999-12-22

Applicant: Hugh Boyd Morrison ,  Anthony Edward Stuart ,  Robert Joseph Logan ,  Charles Bryan Hunt ,  Megan Louise Brown ,  Jill Suzanne Allen

Inventor： Hugh Boyd Morrison ,  Anthony Edward Stuart ,  Robert Joseph Logan ,  Charles Bryan Hunt ,  Megan Louise Brown ,  Jill Suzanne Allen

IPC: H04N5/445 ,  H04N7/173 ,  G06F3/00

CPC classification number: H04N5/44543 ,  H04N21/4334 ,  H04N21/4345 ,  H04N21/435 ,  H04N21/478 ,  H04N21/4782 ,  H04N21/4786 ,  H04N21/482 ,  H04N21/812 ,  H04N21/8173

Abstract: A video processing apparatus may be controlled in response to selecting an advertisement displayed in connection with a productivity or communication application software program being operated on a video processing apparatus. The advertisement includes control information, which is used by the video processing apparatus to control an operating mode thereof. The control information may include both time and channel data as well as a recording data for programming a timer. Alternately, the control information may only include program data, which is passed to the electronic program guide to determine the time and channel information associated with the program data.

Abstract translation: 可以响应于选择与在视频处理设备上操作的生产力或通信应用软件程序一起显示的广告来控制视频处理设备。 广告包括由视频处理设备用于控制其操作模式的控制信息。 控制信息可以包括时间和频道数据以及用于编程定时器的记录数据。 或者，控制信息可以仅包括被传递到电子节目指南以确定与节目数据相关联的时间和频道信息的节目数据。

公开(公告)号：US20100303264A1

公开(公告)日：2010-12-02

申请号：US12746357

申请日：2008-12-08

Applicant: Edward Stuart Fletcher

Inventor： Edward Stuart Fletcher

IPC: H04R5/02

CPC classification number: H04R5/02 ,  H04R1/24 ,  H04R1/2842 ,  H04R1/323 ,  H04R2205/022

Abstract: Apparatus for reproduction of stereo sound from a two channel signal, having one or more first transducers (3a, 3b) for reproducing a signal comprising one of or the sum of the two channels, and one or more second transducers (5) for reproducing a signal comprising the difference between the two channels. The apparatus is arranged such that the signal generated by the one or more first transducers (3a, 3b) is transmitted from an output plane in a direction substantially orthogonal to the output plane. The apparatus also has a duct (6) associated with the one or more second transducers (5) and is arranged to conduct the signal generated by the one or more second transducers (5) such that it is transmitted along a direction substantially parallel to the output plane from a point spaced from the plane in the direction in which the signal generated by the one or more first transducers (3a, 3b) is transmitted.

Abstract translation: 用于从双通道信号再现立体声的装置，具有一个或多个第一换能器（3a，3b），用于再现包括两个通道中的一个或两个通道之一的信号;以及一个或多个第二换能器（5），用于再现 信号包括两个通道之间的差异。 该装置被布置为使得由一个或多个第一换能器（3a，3b）产生的信号从输出平面沿大致正交于输出平面的方向传送。 该设备还具有与一个或多个第二换能器（5）相关联的管道（6），并且布置成传导由一个或多个第二换能器（5）产生的信号，使得其沿着基本上平行于 输出平面从与由所述一个或多个第一换能器（3a，3b）产生的信号的方向相对的平面间隔开的点。