公开(公告)号：US20110127405A1

公开(公告)日：2011-06-02

申请号：US12992963

申请日：2009-05-18

申请人： Nir Grossman ,  Patrick Degenaar ,  Konstantin Nikolic ,  Mark Neil ,  Gordon Kennedy ,  Vincent Poher

发明人： Nir Grossman ,  Patrick Degenaar ,  Konstantin Nikolic ,  Mark Neil ,  Gordon Kennedy ,  Vincent Poher

IPC分类号： G01J1/16 ,  A61N5/06 ,  G02B21/06

CPC分类号： G02B21/004 ,  G01N21/6458 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/16

摘要： This invention describes a device for optical stimulation of cells and other biological structures. It has an ability to target multiple cells and/or multiple sub-cellular targets. The stimulation optical pattern on each cell can be independently controlled with individual frequencies. The light sensitivity of the cells can be imparted as a result of genetic expression of surface and/or subsurface proteins, chemical modification of existing proteins, or via the release of caged entities which in turn act to stimulate the cell through chemical means. The embodiment is capable of functioning on neurons but can also be used for other cells. It can perform optimal stimulation with sub-cellular resolutions, record the activity of the targeted cells and perform processing to ensure calibration.

摘要翻译： 本发明描述了用于光学刺激细胞和其他生物结构的装置。 它具有靶向多个细胞和/或多个亚细胞靶标的能力。 每个单元上的刺激光学图案可以独立地用各个频率控制。 由于表面和/或地下蛋白质的遗传表达，现有蛋白质的化学修饰，或通过释放的笼状实体，细胞的光敏感性可以赋予细胞，这些实体又通过化学方式刺激细胞。 该实施例能够在神经元上起作用，但也可用于其他细胞。 它可以用亚细胞分辨率执行最佳刺激，记录目标细胞的活性，并进行处理以确保校准。

公开(公告)号：US20160000590A1

公开(公告)日：2016-01-07

申请号：US14681076

申请日：2015-04-07

申请人： Edward Stuart Boyden ,  Giovanni Talei Franzesi ,  Christian Wentz ,  Nir Grossman ,  Elazer R. Edelman ,  Colin Derdeyn ,  Eric Leuthardt

发明人： Edward Stuart Boyden ,  Giovanni Talei Franzesi ,  Christian Wentz ,  Nir Grossman ,  Elazer R. Edelman ,  Colin Derdeyn ,  Eric Leuthardt

IPC分类号： A61F2/90 ,  A61B5/07 ,  A61B5/00 ,  A61N2/02 ,  A61B5/04

CPC分类号： A61F2/90 ,  A61B5/026 ,  A61B5/04 ,  A61B5/076 ,  A61B5/686 ,  A61B5/6862 ,  A61F2/82 ,  A61F2230/0069 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36117 ,  A61N1/375 ,  A61N1/3787 ,  A61N2/02

摘要： An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. The device includes an internal skeleton, a flexible substrate attached to the exterior of the skeleton, at least one pair of electrodes located on the substrate, and power and control circuitry connected to the electrodes. The power and control circuitry may include connectors for direct powering of the electrodes or circuit elements for wireless powering of the device by RF-based, optical-based, ultrasound-based, piezoelectric, or vibrational energy harvesting methods. The power and control circuitry may include circuit elements for wireless communication, including between the device and the external environment, and may include on-board processing for control of the electrodes.

摘要翻译： 电子血管内装置被放置成与血管壁紧密接触并且用于血管壁和周围靶组织的电刺激和/或电记录。 电极可以通过将它们连接到外部硬件的连接器进行操作，或者可以结合电子器件以允许无线电力，信息传输和控制。 该装置包括内部骨架，附接到骨架外部的柔性基底，位于基底上的至少一对电极以及连接到电极的电力和控制电路。 功率和控制电路可以包括用于直接为电极或电路元件供电的连接器，用于通过基于RF的，基于光学的，基于超声的，压电的或振动能量收集方法来无线供电设备。 功率和控制电路可以包括用于无线通信的电路元件，包括在设备和外部环境之间，并且可以包括用于控制电极的板载处理。