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    Controlled release systems containing heparin and growth factors
    12.
    发明授权
    Controlled release systems containing heparin and growth factors 失效
    含有HEPARIN和生长因子的控制释放系统

    公开(公告)号：US5100668A

    公开(公告)日：1992-03-31

    申请号：US206520

    申请日：1988-06-14

    Applicant: Elazer R. Edelman ,  Robert S. Langer ,  Michael Klagsburn ,  Edith Mathiowitz

    Inventor： Elazer R. Edelman ,  Robert S. Langer ,  Michael Klagsburn ,  Edith Mathiowitz

    IPC: A61K9/16 ,  A61K9/50 ,  A61K38/18 ,  A61K47/48

    CPC classification number: A61K47/4823 ,  A61K38/1825 ,  A61K9/167 ,  A61K9/5036 ,  Y10S530/813 ,  Y10S530/815 ,  Y10S530/816

    Abstract: A system for stabilizing fibroblast-derived growth factors, maintaining their bioactivity over a prolonged period of time and controllably releasing them for use is disclosed. The system uses growth factors bound to biocompatible substrates via heparin or heparin derived compounds to maintain the bioactivity of the growth factors. A growth factor bound to a heparin coated substrate can be used independently as a controlled release device, or can be incorporated into a reservoir or matrix type controlled release devices to further enhance the controlled release properties. The stabilized growth factors can be implanted into a patient, thereby providing a means for producing an in vivo controlled release of a growth factor to the patient.

    Abstract translation: 公开了一种用于稳定成纤维细胞衍生生长因子的系统，其在长时间内保持其生物活性并且可控地释放它们以供使用。 该系统使用通过肝素或肝素衍生的化合物结合生物相容性底物的生长因子，以维持生长因子的生物活性。 与肝素包被的底物结合的生长因子可以独立地用作控释装置，或者可以并入储存器或基质型受控释放装置中以进一步增强控制释放性质。 可以将稳定的生长因子植入患者体内，从而提供生产体内受控制的生长因子释放给患者的手段。

    MECHANICAL TESTING SYSTEM AND METHOD
    15.
    发明申请
    MECHANICAL TESTING SYSTEM AND METHOD 有权
    机械试验系统及方法

    公开(公告)号：US20130042697A1

    公开(公告)日：2013-02-21

    申请号：US13695343

    申请日：2011-05-31

    Applicant: Elazer R. Edelman ,  Kay Dee Furman ,  Gerard J. Desany

    Inventor： Elazer R. Edelman ,  Kay Dee Furman ,  Gerard J. Desany

    IPC: G01N3/20 ,  G01N3/22 ,  G01N3/08

    CPC classification number: G01N3/08 ,  G01N3/04 ,  G01N3/32 ,  G01N2203/0005 ,  G01N2203/0023 ,  G01N2203/0026 ,  G01N2203/0028 ,  G01N2203/0073 ,  G01N2203/0089 ,  G01N2203/0242 ,  G01N2203/0246 ,  G01N2203/0266 ,  G01N2203/0274 ,  G01N2203/0435

    Abstract: A fixture facilitates using a linear force of a uni-axial test machine to subject a test sample to bending forces. The test machine includes a frame and a crosshead. To generate the linear force, the crosshead translates with reference to the frame in a plane of motion. The fixture includes an upper connecting link, a lower connecting link, and two transverse arms. The upper connecting link is configured to attach to the crosshead for receiving the linear force, and the lower connecting link is configured to attach to the frame. The two transverse arms are pivotably carried between the upper and lower links. Each transverse arm has an inner end configured to attach to the test sample, the test sample being suspended between the arms. The transverse arms pivot in opposite directions in response to the linear force applied to the upper connecting link, exposing the sample to bending forces.

    Abstract translation: 固定装置有助于使用单轴测试机的线性力来使测试样品承受弯曲力。 试验机包括框架和十字头。 为了产生线性力，十字头在运动平面中相对于框架平移。 固定装置包括上连接连杆，下连接连杆和两横向臂。 上连接链接被配置为附接到十字头以接收线性力，并且下连接链路被配置为附接到框架。 两个横向臂可枢转地承载在上部和下部连杆之间。 每个横臂具有构造成附接到测试样品的内端，测试样品悬挂在臂之间。 横向臂响应于施加到上连接连杆的线性力而以相反的方向枢转，将样品暴露于弯曲力。

    Expandable medical device with beneficial agent in openings
    16.
    发明授权
    Expandable medical device with beneficial agent in openings 有权
    具有开口的有益剂的可扩展医疗器械

    公开(公告)号：US08202313B2

    公开(公告)日：2012-06-19

    申请号：US10849324

    申请日：2004-05-19

    Applicant: John F. Shanley ,  Neal L. Eigler ,  Elazer R. Edelman

    Inventor： John F. Shanley ,  Neal L. Eigler ,  Elazer R. Edelman

    IPC: A61F2/82

    CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2250/0004 ,  A61F2250/0068

    Abstract: An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.

    Abstract translation: 一种具有多个细长支柱的可扩张医疗装置，所述多个细长支柱通过延性铰链连接在一起以形成可从具有第一直径的圆柱体膨胀至具有第二直径的圆柱体的基本上圆柱形的装置。 多个支柱和延性铰链被布置成改善支柱的空间分布，这在用支柱输送有益试剂时是特别重要的。 改进的支柱布置扩展到基本上平行四边形的形状，以改善对周围组织的有益剂分布。 有益剂可以装载到支柱内的开口中或涂覆到支柱上以输送到组织。

    ENDOVASCULAR PLATFORMS FOR THE DIFFERENTIAL TARGETING OF MOLECULES TO VESSEL WALL AND VESSEL LUMEN
    17.
    发明申请
    ENDOVASCULAR PLATFORMS FOR THE DIFFERENTIAL TARGETING OF MOLECULES TO VESSEL WALL AND VESSEL LUMEN 审中-公开
    用于差异分配到血管壁和血管壁的分子的内部平台

    公开(公告)号：US20110004293A1

    公开(公告)日：2011-01-06

    申请号：US12834470

    申请日：2010-07-12

    Applicant: Kumaran Kolandaivelu ,  Abraham Tzafriri ,  Vijaya B. Kolachalama ,  Elazer R. Edelman

    Inventor： Kumaran Kolandaivelu ,  Abraham Tzafriri ,  Vijaya B. Kolachalama ,  Elazer R. Edelman

    IPC: A61F2/82

    CPC classification number: A61F2/82 ,  A61F2002/068 ,  A61F2250/0067

    Abstract: A drug delivering medical system intended for placement into a blood vessel is provided. The drug delivering medical system includes a stent device having a plurality of interconnected distinct strut elements comprising distinct strut element surfaces. At least some of the distinct strut surfaces are neither in contact with the lumen wall nor in contact with wall-contacting flow recirculation zones. The stent device releases at least one biologically active compound intended for distal delivery and provides sufficient surface area for delivering the required drug dose to a distal tissue.

    Abstract translation: 提供了用于放置在血管中的药物递送医疗系统。 药物递送医疗系统包括支架装置，其具有包括不同的支柱元件表面的多个互连的不同的支柱元件。 至少一些不同的支柱表面既不与管腔壁接触，也不与壁接触的流动再循环区域接触。 支架装置释放用于远端输送的至少一种生物活性化合物，并提供足够的表面积以将所需药物剂量递送至远端组织。

    EXPANDABLE MEDICAL DEVICE FOR DELIVERY OF BENEFICIAL AGENT
    20.
    发明申请
    EXPANDABLE MEDICAL DEVICE FOR DELIVERY OF BENEFICIAL AGENT 有权
    用于交付受益人的可扩展医疗设备

    公开(公告)号：US20090163995A1

    公开(公告)日：2009-06-25

    申请号：US12390542

    申请日：2009-02-23

    Applicant: John F. Shanley ,  Neal L. Eigler ,  Kinam Park ,  Elazer R. Edelman

    Inventor： John F. Shanley ,  Neal L. Eigler ,  Kinam Park ,  Elazer R. Edelman

    IPC: A61F2/06

    CPC classification number: A61L31/10 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/003 ,  A61F2250/0031 ,  A61F2250/0068 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/622

    Abstract: An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.

    Abstract translation: 可扩张医疗装置具有连接在一起的多个细长支柱，以形成一个基本上圆柱形的装置，该装置可从具有第一直径的圆柱体扩展到具有第二直径的圆筒。 所述多个支柱中的至少一个支柱包括至少部分穿过所述支柱的厚度延伸的至少一个开口。 将有益剂加载到支柱内的开口中以实现试剂的期望的释放动力学。 或者，有益试剂被加载成被配置成实现所需试剂输送曲线的形状。 可以实现各种各样的输送曲线，包括零级，脉冲，增加，减少，正弦和其他输送曲线。

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