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公开(公告)号：US20060019953A1
公开(公告)日：2006-01-26
申请号：US11089701
申请日：2005-03-25
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/506 , C07D413/14 , C07D403/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US06326504B1
公开(公告)日：2001-12-04
申请号：US09154030
申请日：1998-09-16
申请人： Miguel Blasco Piquer , Bautista Enrique Mira Ferri , Juan Gabriel Martinez Fuentes , Gerardo Faus Fortea , Sebastian Subirats Huerta
发明人： Miguel Blasco Piquer , Bautista Enrique Mira Ferri , Juan Gabriel Martinez Fuentes , Gerardo Faus Fortea , Sebastian Subirats Huerta
IPC分类号： C07C100
CPC分类号： A61K36/00 , A61K35/12 , B01D11/0203 , A61K2300/00
摘要： Process for high pressure extraction of organic products from vegetable or animal matrices or extracts thereof wherein the process is carried out in the presence of one or more liquid solvents and one or more supercritical fluids wherein the proportion of the supercritical fluid is less than 50% by weight of the total weight of the solvent and the supercritical fluid.
摘要翻译： 用于从植物或动物基质或其提取物高压提取有机产物的方法，其中所述方法在一种或多种液体溶剂和一种或多种超临界流体的存在下进行，其中超临界流体的比例小于50％ 溶剂和超临界流体的总重量的重量。
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公开(公告)号：US1650223A
公开(公告)日：1927-11-22
申请号：US11775926
申请日：1926-06-22
申请人： GABRIEL MARTINEZ
发明人： GABRIEL MARTINEZ
IPC分类号： B65D75/14
CPC分类号： B65D75/14
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![Pyrrolo[2,3-D]pyrimidines as inhibitors of Janus kinases](/abs-image/US/2013/11/12/US08580802B2/abs.jpg.150x150.jpg)
公开(公告)号：US08580802B2
公开(公告)日：2013-11-12
申请号：US11528779
申请日：2006-09-28
申请人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
IPC分类号： C07D487/04 , C07D295/192 , A61K31/519 , A61K31/5377 , A61K31/496 , A61P25/28 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of the following structural formula: which are useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及以下结构式的化合物：其可用作蛋白激酶的抑制剂，特别是JAK家族激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08314125B2
公开(公告)日：2012-11-20
申请号：US12761502
申请日：2010-04-16
申请人： Andreas P. Termin , Nicole Hilgraf , Tara Leanne Hampton , Gabriel Martinez-Botella , Esther Martinborough
发明人： Andreas P. Termin , Nicole Hilgraf , Tara Leanne Hampton , Gabriel Martinez-Botella , Esther Martinborough
IPC分类号： A61K31/04
CPC分类号： C07D417/12 , C07D401/12
摘要： The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的双环化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08163917B2
公开(公告)日：2012-04-24
申请号：US12775885
申请日：2010-05-07
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120053187A1
公开(公告)日：2012-03-01
申请号：US13216606
申请日：2011-08-24
申请人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, JR.
发明人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, JR.
IPC分类号： A61K31/444 , A61K31/497 , C07D417/14 , C12N9/99 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/06 , C07D401/14 , A61K31/4439
CPC分类号： C07D417/14 , C07D417/04 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20110135603A1
公开(公告)日：2011-06-09
申请号：US12905331
申请日：2010-10-15
申请人： Tiansheng Wang , Alexander Aronov , Mark Cornebise , Francois Maltais , Mark Ledeboer , Arnaud Le Tiran , Valerie Marone , David Messesrsmith , Kevin Cottrell , Jon H. Come , Gabriel Martinez Botella
发明人： Tiansheng Wang , Alexander Aronov , Mark Cornebise , Francois Maltais , Mark Ledeboer , Arnaud Le Tiran , Valerie Marone , David Messesrsmith , Kevin Cottrell , Jon H. Come , Gabriel Martinez Botella
IPC分类号： A61K38/21 , C07D417/10 , A61K31/4439 , A61K38/02 , A61K39/395 , A61P35/00 , C07D513/04 , A61K31/444 , A61P29/00 , A61K39/00 , C12N9/99 , A61P37/02 , A61P37/06
CPC分类号： C07D513/04 , C07D417/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07501415B2
公开(公告)日：2009-03-10
申请号：US11312618
申请日：2005-12-20
申请人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
发明人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
IPC分类号： C07D403/04 , A61K31/506
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
摘要翻译： 本文描述的是可用作ERK2抑制剂的化合物。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括增殖性疾病如癌症）的严重性。
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公开(公告)号：US07244735B2
公开(公告)日：2007-07-17
申请号：US11001760
申请日：2004-12-02
申请人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis
发明人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis
IPC分类号： A61K31/496 , A61K31/506 , C07D239/48
CPC分类号： C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环B，Z 1，Z 2，U，p， Q，R 1，R 2，R 3，R 3和R 3如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种疾病的严重性，包括中风，炎性疾病，自身免疫性疾病如SLE狼疮和牛皮癣，增殖性疾病如癌症，以及与器官移植相关的病症 。
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