公开(公告)号：US07638642B2

公开(公告)日：2009-12-29

申请号：US11572404

申请日：2005-06-23

Applicant: Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Cheol-Kyong Kim ,  Jae-Chul Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

Inventor： Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Cheol-Kyong Kim ,  Jae-Chul Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

IPC: C07D307/02

CPC classification number: C07H3/08

Abstract: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.

Abstract translation: 可以通过本发明的方法容易地和选择性地制备式（III）的3R-羧酸酯对映异构体衍生物，并且可以有效地制备高纯度的D-赤式-2,2-二氟-2-脱氧-1-氧代果糖衍生物 由作为中间体的式（III）化合物制备。

公开(公告)号：US07612207B2

公开(公告)日：2009-11-03

申请号：US12293959

申请日：2007-03-16

Applicant: Kwee Hyun Suh ,  Sang Min Yun ,  Eun Sook Kim ,  Gwan Sun Lee

Inventor： Kwee Hyun Suh ,  Sang Min Yun ,  Eun Sook Kim ,  Gwan Sun Lee

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.

Abstract translation: 本发明涉及一种氯吡格雷1,5-萘二磺酸盐或其水合物的制备方法，该方法包括使氯吡格雷酸加成盐与1,5-萘二磺酸二钠或其水合物在水中或水与有机物的混合物 溶剂。 通过本发明方法可以通过使用1,5-萘二磺酸非腐蚀性二钠制备高质量的氯萘吡格雷1,5-萘二磺酸盐。

公开(公告)号：US20090258908A1

公开(公告)日：2009-10-15

申请号：US12425499

申请日：2009-04-17

Applicant: Tae Hee HA ,  Hee Sook OH ,  Won Jeoung KIM ,  Chang Hee PARK ,  Eun Young KIM ,  Young Hoon KIM ,  Kwee Hyun SUH ,  Gwan Sun LEE

Inventor： Tae Hee HA ,  Hee Sook OH ,  Won Jeoung KIM ,  Chang Hee PARK ,  Eun Young KIM ,  Young Hoon KIM ,  Kwee Hyun SUH ,  Gwan Sun LEE

IPC: A61K31/4439 ,  C07D401/12 ,  A61P1/04

CPC classification number: C07D401/12

Abstract: This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.

Abstract translation: 本发明提供了一种用于预防或治疗胃酸相关疾病的结晶性S-奥美拉唑水合锶，其具有高光学纯度，耐受性，溶解性和不吸湿性，其制备方法和含有该组合物的药物组合物。

公开(公告)号：US20090238838A1

公开(公告)日：2009-09-24

申请号：US11947697

申请日：2007-11-29

Applicant: Dae Jin Kim ,  Sung Min Bae ,  Chang Ki Lim ,  Se Chang Kwon ,  Gwan Sun Lee ,  Dae Hae Song ,  Young Hoon Kim

Inventor： Dae Jin Kim ,  Sung Min Bae ,  Chang Ki Lim ,  Se Chang Kwon ,  Gwan Sun Lee ,  Dae Hae Song ,  Young Hoon Kim

IPC: A61K39/00 ,  C07K16/00 ,  A61P3/10 ,  A61P3/04 ,  A61P9/00

CPC classification number: C07K19/00 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  C07K2319/30

Abstract: The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.

Abstract translation: 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和载体物质及其用途。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。

公开(公告)号：US07449580B2

公开(公告)日：2008-11-11

申请号：US10598790

申请日：2005-03-03

Applicant: Sangmin Yun ,  Eun Sook Kim ,  Hee Seock Kim ,  Tae Hee Ha ,  Kwee-Hyun Suh ,  Gwan Sun Lee

Inventor： Sangmin Yun ,  Eun Sook Kim ,  Hee Seock Kim ,  Tae Hee Ha ,  Kwee-Hyun Suh ,  Gwan Sun Lee

IPC: C07D495/04

CPC classification number: C07D333/38 ,  C07D333/12 ,  C07D333/16 ,  C07D333/18 ,  C07D495/04

Abstract: Ticlopidine and clopidogrel having high blood platelet aggregation inhibitory and anti-thrombotic activities are simply prepared by reacting a substituted thiophene derivative with a 2-chlorobenzylamine derivative.

Abstract translation: 通过使取代的噻吩衍生物与2-氯苄胺衍生物反应，简单地制备具有高血小板聚集抑制和抗血栓形成活性的噻氯匹定和氯吡格雷。

公开(公告)号：US07112672B2

公开(公告)日：2006-09-26

申请号：US10475057

申请日：2002-04-17

Applicant: Gwan-Sun Lee ,  Young-Kil Chang ,  Hong-Sun Kim ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

Inventor： Gwan-Sun Lee ,  Young-Kil Chang ,  Hong-Sun Kim ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

IPC: C07D501/22

CPC classification number: C07D501/00 ,  Y02P20/55

Abstract: A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephem compound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; R1 is hydrogen or R2CH2CO—; and R2 is ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxy

Abstract translation: 通过在碱存在下将亚正膦基头孢烯化合物与乙醛反应在包含二乙醚，式（I）的溶剂混合物中，其中R是羧基保护基，选择性地制备3-（Z） - 丙烯基头孢烯化合物。 R 1是氢或R 2 CH 2 CO-; R 2是乙基，2-噻吩基，苯基，对羟基苯基或苯氧基

公开(公告)号：US07038050B2

公开(公告)日：2006-05-02

申请号：US10526158

申请日：2004-07-19

Applicant: Young Ho Moon ,  Dong Jun Kim ,  Chul-Hyun Park ,  Kyung Ik Lee ,  Jae-Cheol Lee ,  Gwan Sun Lee ,  Young-Kil Chang

Inventor： Young Ho Moon ,  Dong Jun Kim ,  Chul-Hyun Park ,  Kyung Ik Lee ,  Jae-Cheol Lee ,  Gwan Sun Lee ,  Young-Kil Chang

IPC: C07D221/18 ,  C07D221/02

CPC classification number: C07J43/00

Abstract: A method for preparing a 1-androstene derivative which comprises reacting a 2-iodo-androstane derivative with an oxidizing agent while maintaining the pH of the reaction mixture at a specific range gives the 1-androstene derivative with high purity and yield.

Abstract translation: 制备1-雄甾烯衍生物的方法，其包括使2-碘 - 雄甾烷衍生物与氧化剂反应，同时将反应混合物的pH保持在特定范围，得到高纯度和产率的1-雄甾烯衍生物。

公开(公告)号：US06639068B1

公开(公告)日：2003-10-28

申请号：US10111557

申请日：2002-04-24

Applicant: Gwan-Sun Lee ,  Young-Kil Chang ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Keum-Shin Jung

Inventor： Gwan-Sun Lee ,  Young-Kil Chang ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Keum-Shin Jung

IPC: C07D50134

CPC classification number: C07D501/00

Abstract: Highly pure cefpodoxime proxetil can be prepared by a simple process comprising the step of reacting a cefpodoxime salt with 1-iodoethylisopropylcarbonate in an organic solvent in the presence of a crown ether.

Abstract translation: 高纯度头孢泊肟原料可以通过简单的方法制备，包括在冠醚存在下，使头孢泊肟盐与1-碘乙基异丙基碳酸酯在有机溶剂中反应的步骤。

公开(公告)号：US06528628B1

公开(公告)日：2003-03-04

申请号：US09869559

申请日：2001-06-29

Applicant: Kwee-Hyun Suh ,  Nam-Du Kim ,  Hyoung-Jun Pae ,  Gwan-Sun Lee

Inventor： Kwee-Hyun Suh ,  Nam-Du Kim ,  Hyoung-Jun Pae ,  Gwan-Sun Lee

IPC: C07H100

CPC classification number: C07H17/08

Abstract: A new erythromycin A 9-oxime compound which can be effectively used as intermediates for the preparation of erythromycin A oxime compound, a process for preparing the same and a process for preparing 6-O-alkyl erythromycin A or its oxime using the same is described.

Abstract translation: 描述了可以有效地用作制备红霉素A肟化合物的中间体的新的红霉素A 9 - 肟化合物，其制备方法和使用其制备6-O-烷基红霉素A或其肟的方法 。

公开(公告)号：US06515116B2

公开(公告)日：2003-02-04

申请号：US09805831

申请日：2001-03-14

Applicant: Kwee-Hyun Suh ,  Sang-Min Yun ,  Mi-Ra Seong ,  Gi-Jeong Kim ,  Gwan-Sun Lee ,  Nam-Du Kim

Inventor： Kwee-Hyun Suh ,  Sang-Min Yun ,  Mi-Ra Seong ,  Gi-Jeong Kim ,  Gwan-Sun Lee ,  Nam-Du Kim

IPC: C07H1708

CPC classification number: C07H17/08 ,  Y02P20/55

Abstract: High purity Form II crystals of clarithromycin can be easily prepared in a high yield by a process comprising the steps of: protecting the 9-oxime hydroxy group of erythromycin A 9-oxime or a salt thereof with a tropyl group and the 2′- and 4″-hydroxy groups with trimethylsilyl groups; reacting 2′,4″-O-bis(trimethylsilyl)erythromycin A 9-O-tropyloxime with a methylating agent; removing the protecting groups and the oxime group of 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-tropyloxime to obtain crude clarithromycin; treating the crude clarithromycin with methanesulfonic acid in a mixture of a water-miscible organic solvent and water to obtain crystalline clarithromycin mesylate trihydrate; and neutralizing the crystalline clarithromycin mesylate trihydrate with aqueous ammonia in a mixture of a water-miscible organic solvent and water.

Abstract translation: 克拉霉素的高纯度II型晶体可以通过包括以下步骤的方法以高产率容易地制备：保护红霉素A 9-肟的9-肟羟基或其盐与丙基和2'-和 4“ - 羟基与三甲基甲硅烷基; 使2'，4“ - O-双（三甲基甲硅烷基）红霉素A 9-O-草丙基肟与甲基化试剂反应; 除去2'，4“-O-双（三甲基甲硅烷基）-6-O-甲基红霉素A 9-O-草丙基肟的保护基和肟基，得到粗克拉霉素; 在水混溶性有机溶剂和水的混合物中用甲磺酸处理粗克拉霉素，得到结晶克拉硫霉素甲磺酸盐三水合物; 并用水混溶性有机溶剂和水的混合物用氨水中和结晶克拉硫酸甲磺酸盐三水合物。