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公开(公告)号：US09119543B2
公开(公告)日：2015-09-01
申请号：US13321190
申请日：2010-07-23
CPC分类号： A61B5/04004 , A61B5/04001 , A61B5/7239 , A61B2562/0209 , A61B2562/046 , A61N1/0534 , A61N1/36182
摘要： A system (10) and a method for deep brain stimulation are provided. The system (10) comprises a probe (11) and a processor (14). The probe (11) comprises an array of sensing electrodes (12) for acquiring signals representing neuronal activity at corresponding positions in a brain and an array of stimulation electrodes (12) for applying stimulation amplitudes to corresponding brain regions. The processor (14) is operably coupled to the sensing electrodes (12) and the stimulation electrodes (12) and is arranged for performing the method according to the invention. The method comprises receiving (21) the acquired signals from the sensing electrodes (12), processing (22) the acquired signals to find at least one brain region with atypical neuronal activity, based on the acquired signals determining (23) a spatial distribution of stimulation amplitudes over the array of stimulation electrodes (12), and applying (24) the spatial distribution of stimulation amplitudes to the array of stimulation electrodes (12) in order to stimulate the at least one region with atypical neuronal activity.
摘要翻译： 提供一种系统（10）和深脑刺激的方法。 系统（10）包括探针（11）和处理器（14）。 探针（11）包括用于获取表示脑中对应位置的神经元活动的信号的感测电极阵列（12），以及用于对相应的脑区域施加刺激振幅的刺激电极阵列（12）。 处理器（14）可操作地耦合到感测电极（12）和刺激电极（12），并被布置用于执行根据本发明的方法。 该方法包括从所述感测电极（12）接收（21）获取的信号，处理（22）所获取的信号，以基于所获取的信号确定（23）空间分布，以获得具有非典型神经元活动的至少一个脑区域 在刺激电极阵列上的刺激幅度，以及将刺激幅度的空间分布应用于刺激电极阵列（12），以刺激具有非典型神经元活动的至少一个区域。
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公开(公告)号：US09095698B2
公开(公告)日：2015-08-04
申请号：US13517473
申请日：2010-12-21
CPC分类号： A61N1/0534 , A61N1/36082 , A61N1/36182 , A61N1/36185
摘要： System for providing a stimulus comprising a probe with multiple electrodes each capable of providing a particular current to surrounding tissue a generator for providing to each of the electrodes the particular current a controller for controlling the generator to provide current to the electrodes to achieve a desired electrical field around the probe.
摘要翻译： 用于提供刺激的系统，其包括具有多个电极的探针，每个电极能够向周围组织提供特定的电流，用于向每个电极提供特定电流，用于控制发电机以向电极提供电流以实现期望的电 探头周围的场。
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公开(公告)号：US08688230B2
公开(公告)日：2014-04-01
申请号：US13265408
申请日：2010-04-21
申请人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
发明人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
IPC分类号： A61N1/08
CPC分类号： A61N1/375 , A61N1/0529 , A61N1/0539 , A61N1/37229
摘要： A system (102) comprising a box (104) for implanting in a mammal body part (106), which box is provided with a first electrical contact (110, 121, 114, 116, 118, 120), and a module (108) for accommodating in the box, which module is provided with a second electrical contact (122, 124, 126) for cooperation with said first electrical contact. The first electrical contact and the second electrical contact are mutually movable, at least in a stationary accommodation of the module in the box, between a contact position in which said first and second electrical contacts are electrically connected, and a non-contact position in which said first and second electrical contacts are separated from each other.
摘要翻译： 一种系统（102），包括用于植入哺乳动物体部分（106）中的盒（104），所述盒设置有第一电触头（110,121,114,116,118,120）和模块（108 ），用于容纳在盒中，该模块设置有用于与所述第一电触点配合的第二电触点（122,124,126）。 所述第一电触点和所述第二电接触件至少在所述模块在所述模块的静态容纳部中，在所述第一和第二电触点电连接的触点位置和非接触位置之间， 所述第一和第二电触点彼此分离。
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公开(公告)号：US20130030500A1
公开(公告)日：2013-01-31
申请号：US13581484
申请日：2011-02-25
申请人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
发明人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
摘要： A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11). The method comprises sequentially applying a test current to n stimulation electrodes (11), n being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), for each test current at one of the n stimulation electrodes (11), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (η)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (11), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
摘要翻译： 提供一种方法和控制系统（20），用于确定脑刺激探针（10）的刺激设置与相应的V场之间的关系。 脑刺激探针（10）包括多个刺激电极（11）。 V场是围绕刺激电极（11）的脑组织中的电场。 所述方法包括对n个刺激电极（11）依次施加测试电流，n是在刺激探针（10）的刺激电极（11）的数量之间的数量，对于在n个刺激之一的每个测试电流 电极（11），根据刺激设置和所测量的激发电压，测量m个刺激电极处的所得激励电压，m为2个与脑刺激探针（10）的刺激电极（11）的数量之间的数字，导出 耦合矩阵中的元素（q，p），反映两个刺激电极（11）之间的电阻抗的量，并且使用用于确定的耦合矩阵 刺激设置与相应V字段之间的关系。
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公开(公告)号：US20120184837A1
公开(公告)日：2012-07-19
申请号：US13349895
申请日：2012-01-13
IPC分类号： A61B5/0478 , A61B5/0484
CPC分类号： A61N1/0534 , A61B5/0478 , A61B5/0484
摘要： The invention relates to a probe for stimulation and recording of neural activity in the brain, the probe comprising an axially extending shaft. In one embodiment, at least one stimulation electrode partially encircles the shaft besides at a gap, wherein one or more recording electrodes are located in the gap.
摘要翻译： 本发明涉及用于刺激和记录脑中神经活动的探针，该探针包括轴向延伸的轴。 在一个实施例中，除了间隙之外，至少一个刺激电极部分地包围轴，其中一个或多个记录电极位于间隙中。
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16.发明申请公开(公告)号：US20110184492A1
公开(公告)日：2011-07-28
申请号：US13054857
申请日：2009-07-22
IPC分类号： A61N1/36
CPC分类号： A61N1/37288 , A61N1/362 , A61N1/37252
摘要： A system for communicating information between at least two medical devices implanted within the body of a subject using volume conduction of electrical signals as a means of communication and wherein one of the implanted medical devices is configured to provide electrical stimulation to the tissue is disclosed. The system comprises a first implant device having at least two transmit electrodes configured to transmit electrical stimulation pulses, wherein one of the electrodes may be a common return electrode, an encoding means configured to employ a channel as a transmitter transmission medium for stimulation pulses and encoding the information into the stimulation pulses, a second implant device having at least two receive electrodes configured to receive the transmitted stimulation pulses with encoded information, and a decoding means configured to decode the information encoded into the stimulation pulses. The disclosed system provides reliable and efficient communication between implantable receiver devices.
摘要翻译： 公开了一种系统，用于在作为通信手段的电信号的体积传导之间在植入物体内的至少两个医疗设备之间传送信息，并且其中植入的医疗设备中的一个被配置为向组织提供电刺激。 所述系统包括具有至少两个发射电极的第一注入装置，所述至少两个发射电极被配置为传输电刺激脉冲，其中所述电极中的一个可以是公共返回电极，编码装置被配置为使用通道作为用于刺激脉冲的发射器传输介质和编码 将信息输入到刺激脉冲中，具有至少两个接收电极的第二植入装置，所述接收电极被配置为用编码信息接收所发送的刺激脉冲;以及解码装置，被配置为对编码为刺激脉冲的信息进行解码。 所公开的系统在可植入接收器设备之间提供可靠和有效的通信。
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公开(公告)号：US09265932B2
公开(公告)日：2016-02-23
申请号：US13575965
申请日：2011-02-02
CPC分类号： A61N1/0534 , A61N1/36082 , A61N1/36185
摘要： A method and control system for determining and applying stimulation settings for a brain stimulation probe (10, 12) is provided. The brain stimulation probe (10, 12) comprises a plurality of stimulation electrodes (11). The method comprises for multiple stimulation electrodes (11) of the plurality of stimulation electrodes (11): applying a test current and determining a corresponding patient response, determining a volume of influence based (32, 52, 71, 91) on the test current and a position of the stimulation electrode (11), combining the volume of influence (32, 52, 71, 91) and the corresponding patient response with generalized anatomic knowledge of stimulation induced behavior for associating the volume of influence (32, 52, 71, 91) to an anatomic structure (33, 43, 53), and determining an intersection (41, 51) of the volume of influence (32, 52, 71, 91) and the associated anatomic structure (33, 43, 53). Then, based on the determined intersections (41, 51) an optimal stimulation volume and corresponding stimulation settings for the brain stimulation probe (10, 12) are determined.
摘要翻译： 提供了一种用于确定和应用脑刺激探针（10,12）的刺激设置的方法和控制系统。 脑刺激探针（10,12）包括多个刺激电极（11）。 该方法包括多个刺激电极（11）的多个刺激电极（11）：施加测试电流并确定相应的患者反应，确定基于（32,52,71,91）的测试电流的影响体积 以及刺激电极（11）的位置，将影响体积（32,52,71,91）和相应的患者反应与刺激诱发行为的广义解剖学知识相结合以影响体积（32,52,71） ，91）到解剖结构（33,43,53），并且确定影响体积（32,52,71,91）和相关联的解剖结构（33,43,53）的交叉点（41,51） 。 然后，基于确定的交叉点（41,51），确定用于脑刺激探针（10,12）的最佳刺激体积和相应的刺激设置。
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公开(公告)号：US09180299B2
公开(公告)日：2015-11-10
申请号：US12518158
申请日：2007-11-16
CPC分类号： A61N1/36139 , A61N1/05 , A61N1/0529 , A61N1/0534 , A61N1/3605 , A61N1/3606 , A61N1/36082 , A61N1/36185
摘要： The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead; each of the one or more stimulation elements is capable of providing electrical stimulation to the brain tissue in the target area; and each of the one or more sensing elements is capable of detecting electrical signals produced by nerve cells within the brain; wherein after the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiring any additional implantations of the lead after the first implantation. A stimulation system including the DBS lead and a pulse generator is disclosed. Also disclosed is a method of providing therapeutic DBS to brain tissue using the lead.
摘要翻译： 本公开涉及具有远端的深部脑刺激（DBS）引线，其用于向患者的大脑的刺激目标区域中的组织提供治疗性电刺激，包括一个或多个刺激元件的阵列和位于远端的感测元件 领先的结束 所述一个或多个刺激元件中的每一个能够向目标区域中的脑组织提供电刺激; 并且所述一个或多个感测元件中的每一个能够检测由脑内的神经细胞产生的电信号; 其中在沿着通过非外科手术预先确定的轨迹将引线首次植入脑中之后，刺激和感测元件的阵列能够促进目标区域的位置和每个刺激的确定 为了在刺激目标区域中的脑组织提供治疗刺激所需的刺激参数的要素，而不需要在第一次植入之后再进行铅的注入。 公开了包括DBS引线和脉冲发生器的刺激系统。 还公开了使用铅向脑组织提供治疗性DBS的方法。
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公开(公告)号：US08473973B2
公开(公告)日：2013-06-25
申请号：US10563935
申请日：2004-07-02
CPC分类号： G11B7/24038 , G11B7/007 , G11B7/244 , G11B7/258
摘要： The present invention relates to a recordable optical record carrier for recording information using a radiation beam having wavelength λ and incident on an entrance surface of the optical record carrier comprising, in this order: a protective layer facing the entrance surface; first recording stack (L0), the recording stack comprising a recording layer of an organic dye material and a groove structure; a transparent spacer layer sandwiched between the neighboring recording stacks; and a second recording stack (LN) comprising a recording layer, wherein the groove depth of the recording layer of the first recording stack (L0) is in a range from 0.241*λ/nS to 0.362*λ/nS, where nS is a refractive index of a material in a land between grooves on the groove structure.
摘要翻译： 本发明涉及一种用于使用具有波长λ并入射在光学记录载体的入射表面上的辐射束来记录信息的可记录光学记录载体，其包括以下顺序：面对入射表面的保护层; 第一记录堆叠（L0），所述记录堆叠包括有机染料材料的记录层和凹槽结构; 夹在相邻的记录叠层之间的透明间隔层; 以及包括记录层的第二记录堆叠（LN），其中第一记录堆叠（L0）的记录层的凹槽深度在从0.241 *λ/ nS到0.362 *λ/ nS的范围内，其中nS是 凹槽结构中的槽之间的焊盘中的材料的折射率。
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公开(公告)号：US20120150256A1
公开(公告)日：2012-06-14
申请号：US13321190
申请日：2010-07-23
IPC分类号： A61N1/36
CPC分类号： A61B5/04004 , A61B5/04001 , A61B5/7239 , A61B2562/0209 , A61B2562/046 , A61N1/0534 , A61N1/36182
摘要： A system (10) and a method for deep brain stimulation are provided. The system (10) comprises a probe (11) and a processor (14). The probe (11) comprises an array of sensing electrodes (12) for acquiring signals representing neuronal activity at corresponding positions in a brain and an array of stimulation electrodes (12) for applying stimulation amplitudes to corresponding brain regions. The processor (14) is operably coupled to the sensing electrodes (12) and the stimulation electrodes (12) and is arranged for performing the method according to the invention. The method comprises receiving (21) the acquired signals from the sensing electrodes (12), processing (22) the acquired signals to find at least one brain region with atypical neuronal activity, based on the acquired signals determining (23) a spatial distribution of stimulation amplitudes over the array of stimulation electrodes (12), and applying (24) the spatial distribution of stimulation amplitudes to the array of stimulation electrodes (12) in order to stimulate the at least one region with atypical neuronal activity.
摘要翻译： 提供一种系统（10）和深脑刺激的方法。 系统（10）包括探针（11）和处理器（14）。 探针（11）包括用于获取表示脑中对应位置的神经元活动的信号的感测电极阵列（12），以及用于对相应的脑区域施加刺激振幅的刺激电极阵列（12）。 处理器（14）可操作地耦合到感测电极（12）和刺激电极（12），并被布置用于执行根据本发明的方法。 该方法包括从所述感测电极（12）接收（21）获取的信号，处理（22）所获取的信号，以基于所获取的信号确定（23）空间分布，以获得具有非典型神经元活动的至少一个脑区域 在刺激电极阵列上的刺激幅度，以及将刺激幅度的空间分布应用于刺激电极阵列（12），以刺激具有非典型神经元活动的至少一个区域。
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