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公开(公告)号：US09180299B2
公开(公告)日：2015-11-10
申请号：US12518158
申请日：2007-11-16
CPC分类号： A61N1/36139 , A61N1/05 , A61N1/0529 , A61N1/0534 , A61N1/3605 , A61N1/3606 , A61N1/36082 , A61N1/36185
摘要： The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead; each of the one or more stimulation elements is capable of providing electrical stimulation to the brain tissue in the target area; and each of the one or more sensing elements is capable of detecting electrical signals produced by nerve cells within the brain; wherein after the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiring any additional implantations of the lead after the first implantation. A stimulation system including the DBS lead and a pulse generator is disclosed. Also disclosed is a method of providing therapeutic DBS to brain tissue using the lead.
摘要翻译： 本公开涉及具有远端的深部脑刺激（DBS）引线，其用于向患者的大脑的刺激目标区域中的组织提供治疗性电刺激，包括一个或多个刺激元件的阵列和位于远端的感测元件 领先的结束 所述一个或多个刺激元件中的每一个能够向目标区域中的脑组织提供电刺激; 并且所述一个或多个感测元件中的每一个能够检测由脑内的神经细胞产生的电信号; 其中在沿着通过非外科手术预先确定的轨迹将引线首次植入脑中之后，刺激和感测元件的阵列能够促进目标区域的位置和每个刺激的确定 为了在刺激目标区域中的脑组织提供治疗刺激所需的刺激参数的要素，而不需要在第一次植入之后再进行铅的注入。 公开了包括DBS引线和脉冲发生器的刺激系统。 还公开了使用铅向脑组织提供治疗性DBS的方法。
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公开(公告)号：US08688230B2
公开(公告)日：2014-04-01
申请号：US13265408
申请日：2010-04-21
申请人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
发明人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
IPC分类号： A61N1/08
CPC分类号： A61N1/375 , A61N1/0529 , A61N1/0539 , A61N1/37229
摘要： A system (102) comprising a box (104) for implanting in a mammal body part (106), which box is provided with a first electrical contact (110, 121, 114, 116, 118, 120), and a module (108) for accommodating in the box, which module is provided with a second electrical contact (122, 124, 126) for cooperation with said first electrical contact. The first electrical contact and the second electrical contact are mutually movable, at least in a stationary accommodation of the module in the box, between a contact position in which said first and second electrical contacts are electrically connected, and a non-contact position in which said first and second electrical contacts are separated from each other.
摘要翻译： 一种系统（102），包括用于植入哺乳动物体部分（106）中的盒（104），所述盒设置有第一电触头（110,121,114,116,118,120）和模块（108 ），用于容纳在盒中，该模块设置有用于与所述第一电触点配合的第二电触点（122,124,126）。 所述第一电触点和所述第二电接触件至少在所述模块在所述模块的静态容纳部中，在所述第一和第二电触点电连接的触点位置和非接触位置之间， 所述第一和第二电触点彼此分离。
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公开(公告)号：US20130030500A1
公开(公告)日：2013-01-31
申请号：US13581484
申请日：2011-02-25
申请人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
发明人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
摘要： A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11). The method comprises sequentially applying a test current to n stimulation electrodes (11), n being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), for each test current at one of the n stimulation electrodes (11), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (η)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (11), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
摘要翻译： 提供一种方法和控制系统（20），用于确定脑刺激探针（10）的刺激设置与相应的V场之间的关系。 脑刺激探针（10）包括多个刺激电极（11）。 V场是围绕刺激电极（11）的脑组织中的电场。 所述方法包括对n个刺激电极（11）依次施加测试电流，n是在刺激探针（10）的刺激电极（11）的数量之间的数量，对于在n个刺激之一的每个测试电流 电极（11），根据刺激设置和所测量的激发电压，测量m个刺激电极处的所得激励电压，m为2个与脑刺激探针（10）的刺激电极（11）的数量之间的数字，导出 耦合矩阵中的元素（q，p），反映两个刺激电极（11）之间的电阻抗的量，并且使用用于确定的耦合矩阵 刺激设置与相应V字段之间的关系。
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公开(公告)号：US08929992B2
公开(公告)日：2015-01-06
申请号：US13581484
申请日：2011-02-25
申请人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
发明人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
CPC分类号： A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
摘要： A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11). The method comprises sequentially applying a test current to n stimulation electrodes (11), n being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), for each test current at one of the n stimulation electrodes (11), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (η)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (11), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
摘要翻译： 提供一种方法和控制系统（20），用于确定脑刺激探针（10）的刺激设置与相应的V场之间的关系。 脑刺激探针（10）包括多个刺激电极（11）。 V场是围绕刺激电极（11）的脑组织中的电场。 所述方法包括对n个刺激电极（11）依次施加测试电流，n是在刺激探针（10）的刺激电极（11）的数量之间的数量，对于在n个刺激之一的每个测试电流 电极（11），根据刺激设置和所测量的激发电压，测量m个刺激电极处的所得激励电压，m为2个与脑刺激探针（10）的刺激电极（11）的数量之间的数字，导出 耦合矩阵中的元素（q，p），反映两个刺激电极（11）之间的电阻抗的量，并且使用用于确定的耦合矩阵 刺激设置与相应V字段之间的关系。
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公开(公告)号：US20130035585A1
公开(公告)日：2013-02-07
申请号：US13640517
申请日：2011-03-31
IPC分类号： A61B5/055
CPC分类号： G01R33/28 , A61B5/055 , A61B5/061 , A61B90/11 , A61B90/14 , A61B2017/3405 , A61B2090/061 , A61B2090/374 , A61B2090/3954 , G01R33/286 , G01R33/34046 , G01R33/58
摘要： The invention relates to a preparing apparatus for preparing an influencing procedure for influencing a subject. The preparing apparatus (1) comprises a subject coil (3) for generating a magnetic resonance image of he subject (7), an instrument guide device (5) for guiding an instrument (6) for influencing the subject (7), a marker (9) being visible in the magnetic resonance image, and an attaching element for attaching the instrument guide device (5) to the subject coil (3) in a known spatial relationship. Since the spatial relationship between the instrument guide device (5) and the subject coil (3) is known, if they are attached to each other, a time consuming registration procedure for registering an influence trajectory, which has been planned based on the magnetic resonance image, and the instrument guide device (5) can be avoided.
摘要翻译： 本发明涉及一种用于制定影响对象的影响程序的准备装置。 准备装置（1）包括用于产生被检体（7）的磁共振图像的被检体线圈（3），用于引导用于影响被检体（7）的器械（6）的仪器引导装置（5） （9）在磁共振图像中可见，以及用于以已知的空间关系将仪器引导装置（5）附接到对象线圈（3）的附接元件。 由于仪器引导装置（5）与被检体线圈（3）之间的空间关系是已知的，因此如果它们彼此附接，则基于磁共振计划的用于记录影响轨迹的耗时登记过程 图像和仪器引导装置（5）。
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6.发明授权公开(公告)号：US08166876B2
公开(公告)日：2012-05-01
申请号：US11913320
申请日：2006-05-01
IPC分类号： B41F1/00
摘要： A device (1) for transferring a pattern (12) from a stamp (10) to a substrate (20) comprises a table (22) for supporting a substrate (20), a flexible stamp (10) and a movably arranged body (25) having a pressure chamber (27) for exerting pressure on a portion of the stamp (10), so that the portion is pushed toward the substrate (20) and contacts the substrate (20). During a pattern transferring process, the body (25) is moved. As a result, adjacent portions of the stamp (10) successively go through a process of being pushed toward the substrate (20), getting in contact with the substrate (20), and being allowed to move back in place again. In this way, it is achieved that the pattern (12) of the stamp (10) is transferred to the substrate (20), without the introduction of vibrations, so that the transfer of the pattern (12) takes place in a highly accurate fashion.
摘要翻译： 用于将图案（12）从印模（10）传送到基板（20）的装置（1）包括用于支撑基板（20）的台（22），柔性印模（10）和可移动布置的主体 25），其具有用于对所述印模（10）的一部分施加压力的压力室（27），使得所述部分被推向所述基板（20）并与所述基板（20）接触。 在图案转印过程中，主体（25）被移动。 结果，印模（10）的相邻部分依次经过被推向基板（20）的过程，与基板（20）接触，并被允许再次回到原位。 以这种方式，实现了将印模（10）的图案（12）传递到基板（20）而不引入振动，使得图案（12）的转印发生在高精度 时尚。
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7.发明申请Apparatus For Monitoring a Person Having an Interest to an Object, and Method Thereof 审中-公开用于监控对对象感兴趣的人的设备及其方法公开(公告)号：US20080228577A1
公开(公告)日：2008-09-18
申请号：US11997174
申请日：2006-07-31
CPC分类号： G06Q30/0255 , G06K9/00597 , G06Q30/02 , G06T7/70 , G06T2207/30196 , G09F27/00
摘要： The invention relates to a method of monitoring a person having an interest to an object. The method comprising steps of: (210) providing a data processor (111) for obtaining interaction data related to a remote interaction between the person and at least one of a plurality of the objects (131, 132, 133), (240) using the data processor for analysis of the interaction data to identify a particular one of the objects (133), to which the person has the interest, and (250) obtaining additional data related to the particular object for informing the person about the particular object. The analysis of the interaction data may comprise a step (220) of identifying a remote location where the interest of the person is focused, and a step (230) of determining locations of the objects with respect to the remote location.
摘要翻译： 本发明涉及一种监视对物体感兴趣的人的方法。 该方法包括以下步骤：（210）提供数据处理器（111），用于获得与所述人与多个对象（131,132,133），（240）中的至少一个之间的远程交互相关的交互数据，所述交互数据使用 所述数据处理器用于分析所述交互数据以识别所述人感兴趣的对象（133）中的特定一个，以及（250）获得与所述特定对象相关的附加数据，以通知所述人关于所述特定对象。 交互数据的分析可以包括识别人的兴趣被聚焦的远程位置的步骤（220）;以及确定对象相对于远程位置的位置的步骤（230）。
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公开(公告)号：US20080165085A1
公开(公告)日：2008-07-10
申请号：US10598233
申请日：2005-02-22
IPC分类号： G09G3/16
CPC分类号： G02B6/032 , G02B6/001 , G02B6/0073 , G02B6/0096 , G02B6/02 , G02B6/06 , G02B6/4298
摘要： The present invention relates to an elongated display fiber (1) comprising an optical fiber body (2) having a plurality of pixel positions distributed along the length of said fiber (1). At least one light source (3) is arranged to selectively illuminate said fiber (1) from at least one end thereof. Addressing means are operably associated with said fiber for sequential addressing of one of each of said pixel positions. The display fiber (1) further comprises means for selectively causing said fiber (1) to emit light at said addressed one of said pixel positions. The present invention further relates to a display apparatus (11) comprising at least one elongated display fiber (1) according to the present invention.
摘要翻译： 本发明涉及一种细长显示光纤（1），其包括具有沿着所述光纤（1）的长度分布的多个像素位置的光纤体（2）。 至少一个光源（3）布置成从其至少一个端部选择性地照射所述光纤（1）。 寻址装置可操作地与所述光纤相关联，用于顺序寻址每个所述像素位置中的一个。 显示光纤（1）还包括用于选择性地使所述光纤（1）在所述寻址的所述像素位置处发光的装置。 本发明还涉及包括根据本发明的至少一个细长显示纤维（1）的显示装置（11）。
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公开(公告)号：US20080161086A1
公开(公告)日：2008-07-03
申请号：US11815017
申请日：2006-01-27
IPC分类号： A63F3/02
CPC分类号： A63F3/02 , A63F3/00643 , A63F2250/265 , A63F2300/1043 , A63F2300/1075
摘要： A pawn (10) for use on a board (21) is provided. The pawn (10) is arranged to provide a trigger signal upon a touch of a triggerable part of the pawn (10) by a user, and comprises communication means for communicating the trigger signal to a board (21). The pawn (10) comprises at least two separate triggerable sub-parts (11, 12) for, upon a touch of each respective one of the at least two separate triggerable sub-parts (11, 12) by a user, respectively providing a first and a second trigger signal. The first and the second trigger signal are mutually distinguishable. Such a pawn (10) can easily be used for activating a certain function of a set of functions. A function is selected by touching a corresponding triggerable sub-part (11, 12).
摘要翻译： 提供了用于板（21）的棋子（10）。 典当（10）被布置为在用户触摸典当（10）的可触发部分时提供触发信号，并且包括用于将触发信号传送到板（21）的通信装置。 典当（10）包括至少两个单独的可触发子部分（11,12），用于在用户触摸所述至少两个可分离的可触发子部件（11,12）中的每个相应的一个时分别提供 第一和第二触发信号。 第一和第二触发信号是相互区分的。 这样的棋子（10）可以容易地用于激活一组功能的某个功能。 通过触摸相应的可触发子部分（11,12）来选择一个功能。
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公开(公告)号：US09387318B2
公开(公告)日：2016-07-12
申请号：US12442862
申请日：2007-09-21
CPC分类号： A61N1/0529 , A61N1/0472 , A61N1/0476 , A61N1/05
摘要： A stimulation apparatus includes a stimulation lead (102), a multiplexer (114), a stimulation signal generator (116), and a signal detector (120). The stimulation lead (102) includes a plurality of stimulation electrodes (112) disposed in an array about a distal portion of the lead body (110). The arrangement of the electrodes (112) facilitates the controlled steering of stimulating electrical field (118) in three dimensions. Four dimensional field steering may also be provided.
摘要翻译： 刺激装置包括刺激引线（102），多路复用器（114），刺激信号发生器（116）和信号检测器（120）。 刺激引线（102）包括围绕引线主体（110）的远端部分排列成阵列的多个刺激电极（112）。 电极（112）的布置有助于三维地控制刺激电场（118）的转向。 还可以提供四维场转向。
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