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16 条记录 (耗时 0.019 秒)

    Valve Insert
    12.
    发明申请
    Valve Insert 审中-公开
    阀门插入

    公开(公告)号：US20140060673A1

    公开(公告)日：2014-03-06

    申请号：US14002422

    申请日：2012-03-01

    申请人： Ian Lyons

    发明人： Ian Lyons

    IPC分类号： F16K15/03 ,  F16L55/07

    CPC分类号： F16L55/105 ,  E03F7/04 ,  F16K1/2007 ,  F16K15/03 ,  F16K15/031 ,  F16K15/033 ,  F16K27/0227 ,  F16L55/07 ,  F16L55/1018 ,  Y10T137/0486 ,  Y10T137/6017 ,  Y10T137/7903

    摘要： An insert is provided for insertion through an opening in the surface of a conduit, the insert comprising an insert body having first and second open ends defining an axis of flow therebetween. The insert further comprises a valve flap connected to the insert body. The valve flap is movable between a closed position in which it creates a closure, thereby preventing flow along said axis, and an open position in which the valve flap allows flow along the axis. The valve flap is arranged so that, when in the open position, it is substantially U-shaped in side cross-section and is oriented with respect to the insert body so that said U-shape arches over the axis of flow.

    摘要翻译： 提供了用于插入通过导管表面中的开口的插入件，插入件包括具有限定其间的流动轴线的第一和第二开口端的插入体。 插入件还包括连接到插入体的阀瓣。 阀瓣可在闭合位置之间移动，在闭合位置中，阀瓣形成闭合件，从而防止沿着所述轴线的流动，以及阀瓣允许沿轴线流动的打开位置。 阀瓣被布置成使得当处于打开位置时，它在侧截面中基本上为U形，并且相对于插入体定向，使得所述U形弓形件在流动轴线上弯曲。

    Methods for the culture of human embryonic stem cells on human feeder cells
    14.
    发明授权
    Methods for the culture of human embryonic stem cells on human feeder cells 有权
    人胚胎干细胞培养人饲养细胞的方法

    公开(公告)号：US07432104B2

    公开(公告)日：2008-10-07

    申请号：US10486408

    申请日：2002-08-06

    申请人： Maisam Mitalipova ,  Ian Lyons

    发明人： Maisam Mitalipova ,  Ian Lyons

    IPC分类号： C12N5/02 ,  C12N5/08

    CPC分类号： C12N5/0606 ,  A61K35/12 ,  C12N2501/115 ,  C12N2501/235 ,  C12N2502/13 ,  C12N2502/1323 ,  C12N2502/1335 ,  C12N2502/1394 ,  C12N2502/243

    摘要： Methods and cell culture medium for the generation of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human granulosa feeder cells, muscle cells, Fallopian ductal epithelial cells, bone marrow stromal cells, and skin fibroblasts and the embryonic stem cells maintain their pluripotent phenotype. The human pluripotent embryonic stem cells can be cultured without feeder cells, and in the presence of supplemental growth factors. The human pluripotent embryonic stem cells can be alternatively cultured with conditioned medium obtained from a cell culture capable of maintaining human embryonic stem cells in a pluripotent state, wherein the cell culture is a human granulosa cell culture.

    摘要翻译： 公开了用于产生人多能胚胎干细胞的方法和细胞培养基。 人胚胎干细胞与人粒细胞饲养细胞，肌肉细胞，输卵管上皮细胞，骨髓基质细胞和皮肤成纤维细胞一起培养，胚胎干细胞维持其多能表型。 人类多能胚胎干细胞可以在没有饲养细胞的条件下培养，并且在补充生长因子的存在下进行培养。 可以将人多能胚胎干细胞与来自能够维持多能状态的人胚胎干细胞的细胞培养物的条件培养基一起培养，其中细胞培养物是人粒细胞培养物。

    Compositions and methods for neural cell production and stabilization
    15.
    发明申请
    Compositions and methods for neural cell production and stabilization 审中-公开
    神经细胞生成和稳定化的组成和方法

    公开(公告)号：US20060211111A1

    公开(公告)日：2006-09-21

    申请号：US10539951

    申请日：2003-12-18

    申请人： Maisam Mitalipova ,  Ian Lyons ,  Brian Condie ,  Allan Robins ,  Scott Noggle

    发明人： Maisam Mitalipova ,  Ian Lyons ,  Brian Condie ,  Allan Robins ,  Scott Noggle

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0618 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2501/235 ,  C12N2502/14 ,  C12N2506/02

    摘要： The present invention provides compositions and methods for mammalian neural cell production, their stabilization and their proliferation. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a cell line or in cell culture and further contacting the cells with MEDII conditioned medium for the generation of stable mammalian neural cells from pluripotent mammalian stem cells. The invention further provides methods for the stabilization of a neural cell in culture comprising contacting the neural cell with MEDII conditioned medium. Preferably, the stabilized neural cell is a neural progenitor cell.

    摘要翻译： 本发明提供哺乳动物神经细胞产生的组合物和方法，其稳定化及其增殖。 更具体地说，本发明提供了细胞分化方法，其通过在细胞系或细胞培养物中培养细胞并进一步使细胞与MEDII条件培养基接触，用于从多能哺乳动物干细胞产生稳定的哺乳动物神经细胞。 本发明还提供了稳定培养物中神经细胞的方法，包括使神经细胞与MEDII条件培养基接触。 优选地，稳定的神经细胞是神经祖细胞。