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公开(公告)号：US09522501B2
公开(公告)日：2016-12-20
申请号：US12886631
申请日：2010-09-21
申请人： Brett Ian Lyons
发明人： Brett Ian Lyons
IPC分类号： B29C67/00
CPC分类号： B22F3/1055 , B22F2003/1057 , B22F2003/1058 , B28B1/001 , B28B17/0081 , B29C64/153 , B29C64/35 , B29C64/386 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y50/02 , B33Y70/00
摘要： A method and apparatus for forming objects. Layers of precursor material may be placed on top of each other. The layers of precursor material may be selectively cured as the layers of precursor material are placed on top of each other to form an object and a frame associated with the object.
摘要翻译： 一种用于形成物体的方法和装置。 前体材料层可以放置在彼此的顶部。 当前体材料的层被放置在彼此的顶部上以形成与物体相关联的物体和框架时，可以选择性地固化前体材料层。
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公开(公告)号：US20160319977A1
公开(公告)日：2016-11-03
申请号：US15144420
申请日：2016-05-02
申请人： Ian Lyons
发明人： Ian Lyons
CPC分类号： F16L55/105 , E03F7/04 , F16K1/2007 , F16K15/03 , F16K15/031 , F16K15/033 , F16K27/0227 , F16L55/07 , F16L55/1018 , Y10T137/0486 , Y10T137/6017 , Y10T137/7903
摘要： An insert is provided for insertion through an opening in the surface of a conduit, the insert comprising an insert body having find and second open ends defining an axis of !low therebetween The insert further comprises a valve flap connected to the insert body. The valve clap is moveable between a closed position, in which it creates a closure, thereby preventing flow along said axis, and an open position in which the valve flap allows flow along the axis. The valve (lap is arranged so that, when in the open position, it is substantially U-shaped in side cross-section and is oriented with respect to the insert body so that said U-shape articles over the axis of flow.
摘要翻译： 插入件被提供用于通过导管表面中的开口插入，插入件包括插入体，该插入体具有发现和第二开口端，所述插入体具有限定在其上的低轴的轴向。插入件还包括连接到插入体的瓣瓣。 阀瓣可以在闭合位置之间移动，在闭合位置中，其产生闭合件，从而防止沿着所述轴线的流动，以及阀瓣允许沿轴线流动的打开位置。 阀（搭接布置成使得当处于打开位置时，其在侧截面中基本上为U形，并相对于插入体定向，使得所述U形制品在流动轴线上。
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公开(公告)号：US09353875B2
公开(公告)日：2016-05-31
申请号：US14002422
申请日：2012-03-01
申请人： Ian Lyons
发明人： Ian Lyons
CPC分类号： F16L55/105 , E03F7/04 , F16K1/2007 , F16K15/03 , F16K15/031 , F16K15/033 , F16K27/0227 , F16L55/07 , F16L55/1018 , Y10T137/0486 , Y10T137/6017 , Y10T137/7903
摘要： An insert is provided for insertion through an opening in the surface of a conduit, the insert comprising an insert body having first and second open ends defining an axis of flow therebetween. The insert further comprises a valve flap connected to the insert body. The valve flap is movable between a closed position in which it creates a closure, thereby preventing flow along said axis, and an open position in which the valve flap allows flow along the axis. The valve flap is arranged so that, when in the open position, it is substantially U-shaped in side cross-section and is oriented with respect to the insert body so that said U-shape arches over the axis of flow.
摘要翻译： 提供了用于插入通过导管表面中的开口的插入件，插入件包括具有限定其间的流动轴线的第一和第二开口端的插入体。 插入件还包括连接到插入体的阀瓣。 阀瓣可在闭合位置之间移动，在闭合位置中，阀瓣形成闭合件，从而防止沿所述轴线的流动，以及阀瓣允许沿轴线流动的打开位置。 阀瓣被布置成使得当处于打开位置时，它在侧截面中基本上为U形，并且相对于插入体定向，使得所述U形弓形件在流动轴线上弯曲。
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公开(公告)号：US20100171241A1
公开(公告)日：2010-07-08
申请号：US12349204
申请日：2009-01-06
IPC分类号： B29C35/08
CPC分类号： B29C64/153 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： A method and apparatus is present for manufacturing parts. A powder material is comprised of a polymer that is semi-crystalline. The powder material has an overlap between a melting temperature range and a crystallization temperature range. The powder material also has a size particular distribution that is substantially a Gaussian distribution, a particle shape that is substantially spherical, and a desired melt flow rate that is less than a temperature at which the powder material begins to chemically break down. The powder material is selected to form a selected powder material. A part is manufactured using an energy delivery system and the selected powder material.
摘要翻译： 存在用于制造零件的方法和装置。 粉末材料由半结晶的聚合物组成。 粉末材料在熔融温度范围和结晶温度范围之间具有重叠。 粉末材料还具有基本上高斯分布，基本上为球形的粒子形状和小于粉末材料开始化学分解的温度的期望的熔体流动速率的尺寸特定分布。 选择粉末材料以形成选定的粉末材料。 使用能量输送系统和所选择的粉末材料制造零件。
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公开(公告)号：US20090186407A1
公开(公告)日：2009-07-23
申请号：US12104364
申请日：2008-04-16
申请人： Maisam Mitalipova , Ian Lyons
发明人： Maisam Mitalipova , Ian Lyons
IPC分类号： C12N5/08
CPC分类号： C12N5/0606 , A61K35/12 , C12N2501/115 , C12N2501/235 , C12N2502/13 , C12N2502/1323 , C12N2502/1335 , C12N2502/1394 , C12N2502/243
摘要： Methods and cell culture medium for the generation and maintenance of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human feeder cell conditioned medium, and the embryonic stem cells maintain their pluripotent phenotype. The human pluripotent embryonic stem cells can be cultured without feeder cells, and in the presence of supplemental growth factors.
摘要翻译： 公开了用于产生和维持人多能胚胎干细胞的方法和细胞培养基。 人胚胎干细胞与人饲养细胞条件培养基一起培养，胚胎干细胞维持其多能表型。 人类多能胚胎干细胞可以在没有饲养细胞的条件下培养，并且在补充生长因子的存在下进行培养。
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公开(公告)号：US09933102B2
公开(公告)日：2018-04-03
申请号：US15144420
申请日：2016-05-02
申请人： Ian Lyons
发明人： Ian Lyons
CPC分类号： F16L55/105 , E03F7/04 , F16K1/2007 , F16K15/03 , F16K15/031 , F16K15/033 , F16K27/0227 , F16L55/07 , F16L55/1018 , Y10T137/0486 , Y10T137/6017 , Y10T137/7903
摘要： An insert is provided for insertion through an opening in the surface of a conduit, the insert comprising an insert body having first and second open ends defining an axis of flow therebetween. The insert further comprises a valve flap connected to the insert body. The valve flap is moveable between a closed position in which it creates a closure, thereby preventing flow along said axis, and an open position in which the valve flap allows flow along the axis. The valve flap is arranged so that, when in the open position, it is substantially U-shaped in side cross-section and is oriented with respect to the insert body so that said U-shape arches over the axis of flow.
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7.发明授权Method, apparatus and material mixture for direct digital manufacturing of fiber reinforced parts 有权用于直接数字制造纤维增强件的方法，设备和材料混合物公开(公告)号：US09457521B2
公开(公告)日：2016-10-04
申请号：US13223924
申请日：2011-09-01
CPC分类号： B29C70/88 , B22F3/1055 , B29C64/00 , B29C67/0051 , B33Y10/00 , B33Y30/00 , C22C47/025 , C22C47/04 , Y02P10/295
摘要： A part is manufactured by introducing magnetic particles into a matrix material, and orienting the particles by coupling them with an electromagnetic field. The matrix material is solidified in patterned layers while the particles remain oriented by the field.
摘要翻译： 通过将磁性颗粒引入基质材料中并通过将它们与电磁场耦合来定向颗粒来制造零件。 基体材料在图案化层中固化，而颗粒保持由场取向。
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公开(公告)号：US08709330B2
公开(公告)日：2014-04-29
申请号：US12349204
申请日：2009-01-06
IPC分类号： B29C67/00
CPC分类号： B29C64/153 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： A method and apparatus is present for manufacturing parts. A powder material is comprised of a polymer that is semi-crystalline. The powder material has an overlap between a melting temperature range and a crystallization temperature range. The powder material also has a size particular distribution that is substantially a Gaussian distribution, a particle shape that is substantially spherical, and a desired melt flow rate that is less than a temperature at which the powder material begins to chemically break down. The powder material is selected to form a selected powder material. A part is manufactured using an energy delivery system and the selected powder material.
摘要翻译： 存在用于制造零件的方法和装置。 粉末材料由半结晶的聚合物组成。 粉末材料在熔融温度范围和结晶温度范围之间具有重叠。 粉末材料还具有基本上高斯分布，基本上为球形的粒子形状和小于粉末材料开始化学分解的温度的期望的熔体流动速率的尺寸特定分布。 选择粉末材料以形成选定的粉末材料。 使用能量输送系统和所选择的粉末材料制造零件。
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公开(公告)号：US20050037488A1
公开(公告)日：2005-02-17
申请号：US10486408
申请日：2002-08-06
申请人： Maisam Mitalipova , Ian Lyons
发明人： Maisam Mitalipova , Ian Lyons
IPC分类号： A61K35/12 , C12N5/02 , C12N5/0735 , C12N5/08
CPC分类号： C12N5/0606 , A61K35/12 , C12N2501/115 , C12N2501/235 , C12N2502/13 , C12N2502/1323 , C12N2502/1335 , C12N2502/1394 , C12N2502/243
摘要： Methods and cell culture medium for the generation of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human granulosa feeder cells, muscle cells, Fallopian ductal epithelial cells, bone marrow stromal cells, and skin fibroblasts and the embryonic stem cells maintain their pluripotent phenotype. The human pluripotent embryonic stem cells can be cultured without feeder cells, and in the presence of supplemental growth factors. The human pluripotent embryonic stem cells can be alternatively cultured with conditioned medium obtained from a cell culture capable of maintaining human embryonic stem cells in a pluripotent state, wherein the cell culture is a human granulosa cell culture.
摘要翻译： 公开了用于产生人多能胚胎干细胞的方法和细胞培养基。 人胚胎干细胞与人粒细胞饲养细胞，肌肉细胞，输卵管上皮细胞，骨髓基质细胞和皮肤成纤维细胞一起培养，胚胎干细胞维持其多能表型。 人类多能胚胎干细胞可以在没有饲养细胞的条件下培养，并且在补充生长因子的存在下进行培养。 可以将人多能胚胎干细胞与来自能够维持多能状态的人胚胎干细胞的细胞培养物的条件培养基一起培养，其中细胞培养物是人粒细胞培养物。
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公开(公告)号：US10371304B2
公开(公告)日：2019-08-06
申请号：US15903453
申请日：2018-02-23
申请人： Ian Lyons
发明人： Ian Lyons
摘要： An insert is provided for insertion through an opening in the surface of a conduit, the insert comprising an insert body having first and second open ends defining an axis of flow therebetween. The insert further comprises a valve flap connected to the insert body. The valve flap is moveable between a closed position in which it creates a closure, thereby preventing flow along said axis, and an open position in which the valve flap allows flow along the axis. The valve flap is arranged so that, when in the open position, it is substantially U-shaped in side cross-section and is oriented with respect to the insert body so that said U-shape arches over the axis of flow.
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