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    Method for preparing microparticles using liquid-liquid extraction
    15.
    发明授权
    Method for preparing microparticles using liquid-liquid extraction 有权
    使用液 - 液萃取制备微粒的方法

    公开(公告)号：US06884372B2

    公开(公告)日：2005-04-26

    申请号：US10821941

    申请日：2004-04-12

    Applicant: J. Michael Ramstack

    Inventor： J. Michael Ramstack

    IPC: A61K9/16 ,  B01J13/12 ,  B01J13/02 ,  B32B5/16

    CPC classification number: A61K9/1647 ,  A61K9/1694 ,  B01J13/12 ,  Y10T428/2982

    Abstract: Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the separated second phase, which is then returned (solvent poor) to the emulsion. This process of separation of a solvent rich phase, extraction of solvent, and return of a solvent poor phase, is carried out until a selected level of solvent in the emulsion is achieved. Alternatively, the separated solvent rich phase is not returned to the emulsion, but replaced with another solution, such as an aqueous solution, that is free from solvent. The solvent is preferably extracted into an extraction liquid that functions as a “solvent sink” for the solvent.

    Abstract translation: 使用液 - 液萃取制备微粒的方法和装置。 将第一相和第二相组合形成乳液。 将第二相的一部分与乳液分离（富溶剂），并从分离的第二相中提取溶剂，然后将其返回（溶剂不良）至乳液。 进行富溶相的分离，萃取溶剂和返回溶剂不良阶段的过程，直到达到乳液中所选择的溶剂含量。 或者，分离的富溶相不会返回到乳液中，而是用不含溶剂的另一溶液如水溶液代替。 优选将溶剂萃取到作为溶剂的“溶剂槽”的萃取液中。

    Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
    19.
    发明授权
    Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent 失效
    制备延长的保质期的可生物降解的生物相容的含有生物活性剂的微粒

    公开(公告)号：US5792477A

    公开(公告)日：1998-08-11

    申请号：US850679

    申请日：1997-05-02

    Applicant: Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis ,  Jean Mesens

    Inventor： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis ,  Jean Mesens

    IPC: A61K9/56 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K9/58 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/529 ,  A61K47/30 ,  A61K47/34 ,  B01J13/04 ,  B01J13/06 ,  B29B9/00 ,  B01J13/02 ,  B32B5/16

    CPC classification number: B01J13/04 ,  A61K31/519 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  Y10T428/2985

    Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymeric encapsulating binder, and an active agent having limited water solubility dissolved or dispersed in a solvent. An aqueous second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The two phases are separated. The discontinuous first phase is washed with water, or an aqueous solution of water and a solvent for residual solvent in the first phase, to reduce the level of residual solvent in the microparticles to less than about 2% by weight of the microparticles. Also disclosed are a microencapsulated drug prepared by the method for preparing biodegradable, biocompatible microparticles, and a pharmaceutical composition that includes biodegradable and biocompatible microparticles in a pharmaceutically acceptable carrier.

    Abstract translation: 一种制备可生物降解的生物相容性微粒的方法。 制备包含可生物降解的生物相容性聚合物包封粘合剂和溶解或分散在溶剂中的水溶性有限的活性剂的第一相。 制备水相第二相。 第一和第二相组合形成乳液，其中第一相是不连续的，第二相是连续的。 两个阶段分开。 不连续的第一相在第一相中用水，水溶液和残留溶剂的溶液洗涤，以将微粒中的残余溶剂的水平降低到微粒的约2重量％。 还公开了通过制备可生物降解的生物相容性微粒的方法制备的微胶囊化药物，以及包含可药用载体中可生物降解和生物相容的微粒的药物组合物。

    Preparation of biodegradable microparticles containing a biologically active agent
    20.
    发明授权
    Preparation of biodegradable microparticles containing a biologically active agent 失效
    含有生物活性剂的生物降解性微粒的制备

    公开(公告)号：US5650173A

    公开(公告)日：1997-07-22

    申请号：US725439

    申请日：1996-10-03

    Applicant: J. Michael Ramstack ,  Paul F. Herbert ,  Jan Strobel ,  Thomas J. Atkins

    Inventor： J. Michael Ramstack ,  Paul F. Herbert ,  Jan Strobel ,  Thomas J. Atkins

    IPC: A61K9/16 ,  A61K9/50 ,  B01J13/02

    CPC classification number: A61K9/1647 ,  A61K9/1694

    Abstract: Disclosed herein is a process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent, wherein a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer. The solvent blend containing the agent and polymer is dispersed in an aqueous solution to form microdroplets. The resulting emulsion is then added to an extraction medium preferably containing at least one of the solvents of the blend, whereby the rate of extraction of each solvent is controlled, whereupon the biodegradable microparticles containing the biologically active agent are formed.

    Abstract translation: 本文公开了一种制备包含可生物降解的聚合物粘合剂和生物活性剂的可生物降解的微粒的方法，其中使用至少两种不含卤代烃的基本上无毒的溶剂的混合物来溶解或分散该试剂并溶解该聚合物 。 将含有试剂和聚合物的溶剂共混物分散在水溶液中以形成微滴。 然后将所得乳液加入到优选含有至少一种共混物溶剂的萃取介质中，由此控制每种溶剂的萃取速率，由此形成含有生物活性剂的可生物降解的微粒。

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