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11.发明申请公开(公告)号：US20120269840A1
公开(公告)日：2012-10-25
申请号：US13458232
申请日：2012-04-27
申请人： Susan W. BARNETT , Jan ZUR MEGEDE , Indresh SRIVASTAVA , Ying LIAN , Karin HARTOG , Hong LIU , Catherine GREER , Mark SELBY , Christopher WALKER
发明人： Susan W. BARNETT , Jan ZUR MEGEDE , Indresh SRIVASTAVA , Ying LIAN , Karin HARTOG , Hong LIU , Catherine GREER , Mark SELBY , Christopher WALKER
IPC分类号： C12N15/49 , C12P21/02 , A61P31/18 , C12N15/863 , C12N15/57 , A61K39/21 , C12N15/85 , C12N5/10
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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12.发明申请POLYNUCLEOTIDES ENCODING ANTIGENIC HIV TYPE C POLYPEPTIDES, POLYPEPTIDES AND USES THEREOF 有权多核苷酸编码抗原型HIV多肽，多肽及其用途公开(公告)号：US20110236469A1
公开(公告)日：2011-09-29
申请号：US13108900
申请日：2011-05-16
申请人： Susan W. BARNETT , Jan Zur Megede
发明人： Susan W. BARNETT , Jan Zur Megede
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Gag- and/or Env-containing proteins are also described.
摘要翻译： 本发明涉及编码免疫原性HIV C型Gag-和/或含Env的多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，产生包装细胞系以及产生含Gag和/或含Env的蛋白质的应用中的用途。
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13.发明申请POLYNUCLEOTIDES ENCODING ANTIGENIC HIV TYPE B POLYPEPTIDES, POLYPEPTIDES, AND USES THEREOF 有权编码抗原型HIV多肽的多核苷酸，多肽及其用途公开(公告)号：US20090004733A1
公开(公告)日：2009-01-01
申请号：US12018413
申请日：2008-01-23
申请人： Jan zur Megede , Susan W. Barnett
发明人： Jan zur Megede , Susan W. Barnett
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2740/16022 , C12N2740/16043 , C12N2740/16052 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了在包括免疫，产生包装细胞系以及产生HIV多肽的应用中多核苷酸的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及来自其的这些多核苷酸和多肽产物的用途，包括免疫原性组合物的制剂及其用途。
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14.发明授权Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof 有权编码抗原性HIV C型多肽的多核苷酸，多肽及其用途公开(公告)号：US07211659B2
公开(公告)日：2007-05-01
申请号：US10190435
申请日：2002-07-05
申请人： Jan zur Megede , Susan Barnett
发明人： Jan zur Megede , Susan Barnett
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2720/00034 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2799/027 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了在包括免疫，产生包装细胞系以及产生HIV多肽的应用中多核苷酸的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及来自其的这些多核苷酸和多肽产物的用途，包括免疫原性组合物的制剂及其用途。
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15.发明申请公开(公告)号：US20060057115A1
公开(公告)日：2006-03-16
申请号：US11100356
申请日：2005-04-06
申请人： Jan zur Megede , Susan Barnett
发明人： Jan zur Megede , Susan Barnett
IPC分类号： A61K48/00 , C12N15/867
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2740/16022 , C12N2740/16043 , C12N2740/16052 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
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16.发明授权Method of generating an immune response in a subject using fusion proteins comprising CD4 minimal modules and HIV Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes 失效使用包含CD4最小模块和HIV Tat支架多肽的融合蛋白在受试者中产生免疫应答的方法，其能够结合HIV包膜并暴露神经中和表位公开(公告)号：US08637044B2
公开(公告)日：2014-01-28
申请号：US13427234
申请日：2012-03-22
IPC分类号： A61K39/21 , A61K39/00 , A61K39/385 , C07K1/00
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
摘要翻译： 描述了包含结合HIV Env多肽与一种或多种HIV Tat多肽结合的CD4最小模块或模拟物的杂合分子。 还描述了这些杂合分子与Env的复合物以及使用多核苷酸和多肽进行诊断，治疗和预防的方法。
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17.发明授权公开(公告)号：US08541230B2
公开(公告)日：2013-09-24
申请号：US13108900
申请日：2011-05-16
申请人： Susan W. Barnett , Jan Zur Megede
发明人： Susan W. Barnett , Jan Zur Megede
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Gag- and/or Env-containing proteins are also described.
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18.发明授权Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes 有权包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和人免疫缺陷病毒（HIV）Tat支架多肽的融合蛋白公开(公告)号：US08168194B2
公开(公告)日：2012-05-01
申请号：US11883696
申请日：2006-02-03
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
摘要翻译： 描述了包含结合HIV Env多肽与一种或多种HIV Tat多肽结合的CD4最小模块或模拟物的杂合分子。 还描述了这些杂合分子与Env的复合物以及使用多核苷酸和多肽进行诊断，治疗和预防的方法。
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19.发明授权Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof 失效编码抗原性HIV C型多肽的多核苷酸，多肽及其用途公开(公告)号：US07943375B2
公开(公告)日：2011-05-17
申请号：US12215189
申请日：2008-06-25
申请人： Susan W. Barnett , Jan zur Megede
发明人： Susan W. Barnett , Jan zur Megede
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Gag- and/or Env-containing proteins are also described.
摘要翻译： 本发明涉及编码免疫原性HIV C型Gag-和/或含Env的多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，产生包装细胞系以及产生含Gag和/或含Env的蛋白质的应用中的用途。
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公开(公告)号：US20110045017A1
公开(公告)日：2011-02-24
申请号：US12941176
申请日：2010-11-08
IPC分类号： A61K39/295
CPC分类号： C07K14/005 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/543 , A61K2039/55544 , A61K2039/55594 , A61K2039/575 , A61K2039/6037 , C12N2740/16034 , C12N2740/16222
摘要： This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compositions of the invention can be used to treat or prevent HIV infection.
摘要翻译： 本发明涉及包含HIV抗原和粘膜佐剂的药物组合物以及通过施用这些组合物在受试者中提高免疫应答的方法。 优选地，本发明的药物组合物可用于治疗或预防HIV感染。
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