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公开(公告)号：US20110110977A1
公开(公告)日：2011-05-12
申请号：US12083905
申请日：2006-10-17
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/70 , C12N2740/16134
摘要： Compositions comprising multivalent and adjuvanted HIV Env glycoproteins are described. Methods of using these compositions for treatment and prevention of HIV are also provided.
摘要翻译： 描述了包含多价和佐剂的HIV Env糖蛋白的组合物。 还提供了使用这些组合物治疗和预防HIV的方法。
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2.发明申请公开(公告)号：US20110052632A1
公开(公告)日：2011-03-03
申请号：US12943195
申请日：2010-11-10
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C12N2740/16122 , C12N2740/16134 , A61K2300/00
摘要： The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using these polynucleotides are also disclosed.
摘要翻译： 本公开涉及编码HIV Env多肽的新型多核苷酸。 特别地，本公开涉及编码Env多肽的源自HIV菌株博茨瓦纳MJ4的序列。 还公开了包含这些多核苷酸的组合物和使用这些多核苷酸的方法。
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3.发明申请POLYNUCLEOTIDES ENCODING ANTIGENIC HIV TYPE C POLYPEPTIDES, POLYPEPTIDES AND USES THEREOF 审中-公开多核苷酸编码抗原型HIV多肽，多肽及其用途公开(公告)号：US20100316698A1
公开(公告)日：2010-12-16
申请号：US12620511
申请日：2009-11-17
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of HIV Type C proteins are also described.
摘要翻译： 本发明涉及编码免疫原性HIV C型多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，包装细胞系的产生和HIV C型蛋白的产生的应用中的用途。
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公开(公告)号：US20090208530A1
公开(公告)日：2009-08-20
申请号：US12365215
申请日：2009-02-04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C12N2740/16122 , C12N2740/16134 , A61K2300/00
摘要： The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using polynucleotides are also disclosed.
摘要翻译： 本公开涉及编码HIV Env多肽的新型多核苷酸。 特别地，本公开涉及编码Env多肽的源自HIV菌株博茨瓦纳MJ4的序列。 还公开了包含这些多核苷酸的组合物和使用多核苷酸的方法。
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公开(公告)号：US20070166784A1
公开(公告)日：2007-07-19
申请号：US10571882
申请日：2004-09-15
申请人： Susan Barnett , Victor Gomez-Roman , Ying Lian , Bo Peng , Marjorie Robert-Guroff , Indresh Srivastava
发明人： Susan Barnett , Victor Gomez-Roman , Ying Lian , Bo Peng , Marjorie Robert-Guroff , Indresh Srivastava
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K16/1063 , C07K2317/21 , C07K2317/732 , C07K2317/76 , C12N2740/16134
摘要： The present invention relates to methods, polynucleotides, and polypeptides encoding immunogenic HIV polypeptides derived from different strains within an HIV subtype and/or immunogenic HIV polypeptides from different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are described. The combination approaches described herein have been shown to induce broad and potent neutralizing activity against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
摘要翻译： 本发明涉及编码来自不同亚型的HIV亚型中的不同菌株和/或来自不同亚型的免疫原性HIV多肽的免疫原性HIV多肽的方法，多核苷酸和多肽。 描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 已经显示本文描述的组合方法可以诱导针对给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的中和活性。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。
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公开(公告)号：US20110045017A1
公开(公告)日：2011-02-24
申请号：US12941176
申请日：2010-11-08
IPC分类号： A61K39/295
CPC分类号： C07K14/005 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/543 , A61K2039/55544 , A61K2039/55594 , A61K2039/575 , A61K2039/6037 , C12N2740/16034 , C12N2740/16222
摘要： This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compositions of the invention can be used to treat or prevent HIV infection.
摘要翻译： 本发明涉及包含HIV抗原和粘膜佐剂的药物组合物以及通过施用这些组合物在受试者中提高免疫应答的方法。 优选地，本发明的药物组合物可用于治疗或预防HIV感染。
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公开(公告)号：US07718401B2
公开(公告)日：2010-05-18
申请号：US12026619
申请日：2008-02-06
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 还描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env-，tat-或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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8.发明申请POLYNUCLEOTIDES ENCODING ANTIGENIC HIV TYPE B POLYPEPTIDES, POLYPEPTIDES, AND USES THEREOF 审中-公开编码抗原型HIV多肽的多核苷酸，多肽及其用途公开(公告)号：US20080095833A1
公开(公告)日：2008-04-24
申请号：US11872342
申请日：2007-10-15
申请人： Jan Zur Megede , Susan Barnett , Ying Lian
发明人： Jan Zur Megede , Susan Barnett , Ying Lian
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5156 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了在包括免疫，产生包装细胞系以及产生HIV多肽的应用中多核苷酸的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及来自其的这些多核苷酸和多肽产物的用途，包括免疫原性组合物的制剂及其用途。
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9.发明申请Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof 有权编码抗原性HIV B型多肽的多核苷酸，多肽及其用途公开(公告)号：US20050214256A1
公开(公告)日：2005-09-29
申请号：US10976619
申请日：2004-10-29
申请人： Jan Megede , Susan Barnett , Ying Lian
发明人： Jan Megede , Susan Barnett , Ying Lian
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5156 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了在包括免疫，产生包装细胞系以及产生HIV多肽的应用中多核苷酸的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及来自其的这些多核苷酸和多肽产物的用途，包括免疫原性组合物的制剂及其用途。
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10.发明申请EXPRESSION CASSETTES ENDCODING HIV-1 SOUTH AFRICAN SUBTYPE C MODIFIED PROTEINS 审中-公开表达蛋白质终止HIV-1南非亚型C修饰蛋白公开(公告)号：US20120269851A1
公开(公告)日：2012-10-25
申请号：US13399977
申请日：2012-02-17
申请人： Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse van Rensburg , Thomas J. Scriba
发明人： Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse van Rensburg , Thomas J. Scriba
IPC分类号： C12N15/63 , C12N1/21 , C12N1/19 , A61K48/00 , A61K39/21 , A61P37/04 , A61P31/18 , C12N5/10 , C12P21/02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2720/00034 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2799/027 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polypeptides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了多肽在包括免疫，产生包装细胞系以及产生HIV多肽的应用中的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及来自其的这些多核苷酸和多肽产物的用途，包括免疫原性组合物的制剂及其用途。
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