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公开(公告)号：US08445446B2
公开(公告)日：2013-05-21
申请号：US13135129
申请日：2011-06-23
申请人： Alexander Deiters , Ashton T. Cropp , Jason W. Chin , Christopher J. Anderson , Peter G. Schultz
发明人： Alexander Deiters , Ashton T. Cropp , Jason W. Chin , Christopher J. Anderson , Peter G. Schultz
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US08357532B2
公开(公告)日：2013-01-22
申请号：US13443800
申请日：2012-04-10
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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公开(公告)号：US08114648B2
公开(公告)日：2012-02-14
申请号：US11978188
申请日：2007-10-26
申请人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。
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公开(公告)号：US08114628B2
公开(公告)日：2012-02-14
申请号：US11978121
申请日：2007-10-26
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US20110217733A1
公开(公告)日：2011-09-08
申请号：US11978223
申请日：2007-10-26
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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16.发明申请Methods and compositions for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs 审中-公开用于产生正交tRNA-aminoacyltRNA合成酶对的方法和组合物公开(公告)号：US20110027867A1
公开(公告)日：2011-02-03
申请号：US11978217
申请日：2007-10-26
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
IPC分类号： C12N1/00
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in viva
摘要翻译： 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于将非天然氨基酸掺入viva蛋白质中
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公开(公告)号：US07638300B2
公开(公告)日：2009-12-29
申请号：US11583551
申请日：2006-10-18
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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18.发明申请公开(公告)号：US20090048434A1
公开(公告)日：2009-02-19
申请号：US11982877
申请日：2007-11-06
申请人： Oliver Rackham , Jason W. Chin
发明人： Oliver Rackham , Jason W. Chin
CPC分类号： C12N15/67 , C12N15/1034 , C12N15/1089 , C12N15/11
摘要： Orthogonal ribosome orthogonal mRNA pairs are provided, as are methods for their selection involving a novel positive-negative selection approach, and methods for their use. Also provided are cellular logic circuits involving orthogonal ribosomes.
摘要翻译： 提供正交核糖体正交mRNA对，以及涉及新型阳性 - 阴性选择方法的选择方法及其使用方法。 还提供了涉及正交核糖体的细胞逻辑电路。
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公开(公告)号：US08945926B2
公开(公告)日：2015-02-03
申请号：US13329202
申请日：2011-12-16
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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20.发明申请Methods and Compositions for the Production of Orthogonal tRNA-Aminoacyl tRNA Synthetase Pairs 审中-公开正交tRNA-氨基酰基tRNA合成酶对的制备方法和组合公开(公告)号：US20130309720A1
公开(公告)日：2013-11-21
申请号：US13475792
申请日：2012-05-18
申请人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
摘要翻译： 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于在体内将非天然氨基酸掺入蛋白质。
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