Abstract:
Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.
Abstract:
A power and risk score calibrator is provided, which receives quantitative power and risk scores for each quantitative segment, and receives qualitative power and risk scores for each qualitative segment. The qualitative segment and the qualitative power and risk scores are defined by a user. The system generates consolidated segments. Then consolidated power and risk scores for each of the consolidated segments are generated, respectively. The gaps between the qualitative power and risk scores and the consolidated power and risk scores are reconciled. From these reconciliations, adjustment factors are generated, which are applied by pricing power and risk value calibrators. The system may also perform a drill down to explain the gap between the qualitative scores and the consolidated scores.
Abstract:
An indexable cartridge and method that is useable in either a stagnant fluid environment or in a moving fluid environment with the indexable cartridge floatable in a stagnant fluid environment and securable in a moving fluid environment with the indexable cartridge having a housing having one or more diffusion ports and a sleeve having one or more diffusion ports indexable to a diffusion port alignment through resilient yielding of the sleeve while a set of ribs inhibit lateral flow therebetween.
Abstract:
A system and method for using multiplexed RFID transceivers and RFID tags to verify connections and communicate the connection status to a host system is provided. RFID tags that are programmed with connection specific indicia are attached at or in proximity to various connections in a pharmaceutical or biotech processing system and interrogated by remote antennas driven by a multiplexed RFID transceiver. This enables a user to verify the status of each connection and communicate the connection status to a host system.
Abstract:
The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.
Abstract:
A causality analyzer that provides attribution of causality effects for changes in revenue, margin and margin percentage is provided. The causality analyzer selects a reference time period and a comparison time period, and receives transaction data. Data cleansing and correction may be performed on the transaction data. The analyzer may then calculate change in total margin, percent margin and total revenue between the reference time period and the comparison time period using the transaction data. Each of the total margin, the percent margin and the total revenue may be disaggregated into one or more of a price effect, cost effect, quantity effect, product mix effect, customer mix effect, exchange rate effect, new and lost business, and an adjustment change. In this way the total margin, the percent margin and the total revenue are each defined as a summation of the individual causality effects. Causality effects may be disaggregated in such a way that the shared effects are allocated according to the proportion of percent change for each element, thereby unbiasing the effects to more accurately reflect actual causality.
Abstract:
A revenue causality analyzer that provides attribution of causality effects for changes in revenue. The analyzer includes a selector for selecting a reference time period and a comparison time period, a receiver configured to receive transaction data including pricing data and volume data about the products at reference and comparison times, a preparer that includes a missing data exchanger and data error corrector, an attributor for attributing causality effects including a price effect, a volume effect, a mix effect an exchange effect, a cost effect, a dividend effect, a loss effect, and an inventory appreciation effect, by analyzing transaction data through a causality equation; and an output. Price effect sums the product of change in price and volume of the products across the products and currencies. Volume effect multiplies change in volume by the revenue per product sold. Mix effect multiplies percent revenue change by the volume of products sold.
Abstract:
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
Abstract:
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
Abstract:
A control system comprising a timer based controller and a valve wherein the timer-based controller has a fixed period and the timer based controller regularly cycles the valve between a first condition and a second condition with the first portion of the cycle directing a first flow of water through a dispensable material and the remaining portion of the cycle directing a lesser flow of water through the dispensable material.