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    2-'4(Phenylamino)-Piperidin-1-Yl!-N-Phenyl-Acetamine Derivatives and Related Compounds as Neuropeptide Y5 (NPY5) Ligands for the Treatment of Obesity
    12.
    发明申请
    2-'4(Phenylamino)-Piperidin-1-Yl!-N-Phenyl-Acetamine Derivatives and Related Compounds as Neuropeptide Y5 (NPY5) Ligands for the Treatment of Obesity 失效
    2-'4（苯基氨基）哌啶-1-基] -N-苯基 - 乙酰胺衍生物和相关化合物作为神经肽Y5（NPY5）用于治疗肥胖的配体

    公开(公告)号：US20080119516A1

    公开(公告)日：2008-05-22

    申请号：US10565979

    申请日：2004-07-29

    Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Angeles Fisas Escasany

    Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Angeles Fisas Escasany

    IPC: A61K31/445 ,  A61K31/4468 ,  A61K31/4709 ,  A61P25/00 ,  A61P3/04 ,  A61P5/00 ,  C07D211/58 ,  C07D215/12 ,  C07D401/10

    CPC classification number: C04B35/632 ,  C07D211/58 ,  C07D401/12 ,  C07D405/12

    Abstract: It was an object of the present invention to provide novel compounds that are suitable in particular as active substances in medicaments, preferably in medicaments for the regulation of neuropeptide Y receptors, particularly preferably of neuropeptide Y5 (NPY5) receptor, for the regulation of food ingestion (food intake), preferably for the prophylaxis and/or treatment of disorders of food ingestion, such as obesity, anorexia, cachexia, bulimia or type II (non insulin dependent) diabetes, for the prophylaxis and/or treatment of disorders of the peripheral nervous system, disorders of the central nervous system, anxiety, depression, cognitive disorders, preferably memory disorders, cardiovascular diseases, pain, epilepsy, arthritis, hypertensive syndrom, inflammatory diseases, immune diseases and other NPY5 mediated disorders in animals and mammals, including man. Said object was achieved by providing 1,4-disubstituted piperidine compounds of general formula (I) wherein the substituents are defined in claim 1.

    Abstract translation: 本发明的目的是提供特别适用于药物中的活性物质的新型化合物，优选用于调节神经肽Y受体，特别优选神经肽Y5（NPY5）受体的药物用于调节食物摄取 （食物摄取），优选用于预防和/或治疗食物摄取的疾病，例如肥胖症，厌食症，恶病质，贪食症或II型（非胰岛素依赖型）糖尿病，用于预防和/或治疗外周疾病 神经系统，中枢神经系统疾病，焦虑症，抑郁症，认知障碍，优选记忆障碍，心血管疾病，疼痛，癫痫，关节炎，高血压综合征，炎性疾病，免疫疾病和其他NPY5介导的动物和哺乳动物的疾病，包括人 。 所述目的是通过提供通式（I）的1,4-二取代的哌啶化合物来实现的，其中取代基如权利要求1中所定义。

    2-′4(phenylamino)-piperidin-1-yl!-n-phenyl-acetamine derivatives and related compounds as neuropeptide Y5 (NPY5) ligands for the treatment of obesity
    16.
    发明授权
    2-′4(phenylamino)-piperidin-1-yl!-n-phenyl-acetamine derivatives and related compounds as neuropeptide Y5 (NPY5) ligands for the treatment of obesity 失效
    （苯基氨基） - 哌啶-1-基 - 苯基 - 乙酰胺衍生物和作为治疗肥胖症的神经肽Y5（NPY5）配体的相关化合物

    公开(公告)号：US07888510B2

    公开(公告)日：2011-02-15

    申请号：US10565979

    申请日：2004-07-29

    Applicant: Antoni Jover Torrens ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Angeles Fisas Escasany ,  Helmut-Heinrich Buschmann

    Inventor： Antoni Jover Torrens ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Angeles Fisas Escasany ,  Helmut-Heinrich Buschmann

    IPC: C07D407/12 ,  C07D401/12 ,  A61K31/4525 ,  A61K31/4545

    CPC classification number: C04B35/632 ,  C07D211/58 ,  C07D401/12 ,  C07D405/12

    Abstract: It was an object of the present invention to provide novel compounds that are suitable in particular as active substances in medicaments, preferably in medicaments for the regulation of neuropeptide Y receptors, particularly preferably of neuropeptide Y5 (NPY5) receptor, for the regulation of food ingestion (food intake), preferably for the prophylaxis and/or treatment of disorders of food ingestion, such as obesity, anorexia, cachexia, bulimia or type II (non insulin dependent) diabetes, for the prophylaxis and/or treatment of disorders of the peripheral nervous system, disorders of the central nervous system, anxiety, depression, cognitive disorders, preferably memory disorders, cardiovascular diseases, pain, epilepsy, arthritis, hypertensive syndrome, inflammatory diseases, immune diseases and other NPY5 mediated disorders in animals and mammals, including man. Said object was achieved by providing 1,4-disubstituted piperidine compounds of general formula (I) wherein the substituents are defined in claim 1.

    Abstract translation: 本发明的目的是提供特别适用于药物中的活性物质的新型化合物，优选用于调节神经肽Y受体，特别优选神经肽Y5（NPY5）受体的药物用于调节食物摄取 （食物摄取），优选用于预防和/或治疗食物摄取的疾病，例如肥胖症，厌食症，恶病质，贪食症或II型（非胰岛素依赖型）糖尿病，用于预防和/或治疗外周疾病 神经系统，中枢神经系统疾病，焦虑症，抑郁症，认知障碍，优选记忆障碍，心血管疾病，疼痛，癫痫，关节炎，高血压综合征，炎性疾病，免疫疾病和动物和哺乳动物中的其他NPY5介导的疾病，包括人 。 所述目的是通过提供通式（I）的1,4-二取代的哌啶化合物来实现的，其中取代基如权利要求1中所定义。

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