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    Correction method for differential phase contrast imaging
    13.
    发明授权
    Correction method for differential phase contrast imaging 有权
    差分相位成像校正方法

    公开(公告)号：US08855265B2

    公开(公告)日：2014-10-07

    申请号：US13319527

    申请日：2010-06-10

    申请人： Klaus Juergen Engel ,  Dieter Geller ,  Gereon Vogtmeier

    发明人： Klaus Juergen Engel ,  Dieter Geller ,  Gereon Vogtmeier

    IPC分类号： G03H5/00 ,  A61B6/00 ,  G21K1/06 ,  G01N23/04

    CPC分类号： A61B6/00 ,  A61B6/4092 ,  A61B6/4291 ,  A61B6/484 ,  G01N23/04 ,  G21K1/06 ,  G21K2207/005

    摘要： The present invention generally refers to a correction method for grating-based X-ray differential phase contrast imaging (DPCI) as well as to an apparatus which can advantageously be applied in X-ray radiography and tomography for hard X-ray DPCI of a sample object or an anatomical region of interest to be scanned. More precisely, the proposed invention provides a suitable approach that helps to enhance the image quality of an acquired X-ray image which is affected by phase wrapping, e.g. in the resulting Moiré interference pattern of an emitted X-ray beam in the detector plane of a Talbot-Lau type interferometer after diffracting said X-ray beam at a phase-shifting beam splitter grating. This problem, which is further aggravated by noise in the obtained DPCI images, occurs if the phase between two adjacent pixels in the detected X-ray image varies by more than π radians and is effected by a line integration over the object's local phase gradient, which induces a phase offset error of π radians that leads to prominent line artifacts parallel to the direction of said line integration.

    摘要翻译： 本发明总体上涉及一种用于基于光栅的X射线差分相位对比成像（DPCI）的校正方法以及可以有利地应用于X射线照相术和X射线成像的装置，用于样品的硬X射线DPCI 对象或要扫描的感兴趣的解剖区域。 更精确地，所提出的发明提供了一种合适的方法，其有助于增强受到相位包裹影响的获得的X射线图像的图像质量，例如， 在衍射在相移分束器光栅上的所述X射线束之后，在Talbot-Lau型干涉仪的检测器平面中产生的发射的X射线束的莫尔干涉图。 如果所检测的X射线图像中的两个相邻像素之间的相位变化多于＆pgr，则发生由获得的DPCI图像中的噪声进一步恶化的问题。 弧度并且通过对象的局部相位梯度上的线积分实现，其引起相位偏移误差＆pgr; 导致与所述线集成方向平行的突出的线条伪影的弧度。

    X-RAY IMAGING WITH PIXELATED DETECTOR
    14.
    发明申请
    X-RAY IMAGING WITH PIXELATED DETECTOR 有权
    带有像素探测器的X射线成像

    公开(公告)号：US20130156157A1

    公开(公告)日：2013-06-20

    申请号：US13818696

    申请日：2011-08-30

    申请人： Klaus Juergen Engel ,  Gereon Vogtmeier

    发明人： Klaus Juergen Engel ,  Gereon Vogtmeier

    IPC分类号： G01N23/04

    CPC分类号： G01N23/04 ,  G21K1/025 ,  G21K2207/00 ,  H01J2235/068

    摘要： The invention relates to a method and an imaging system (100) for generating X-ray 101a 101b 101c 101d images. The system (100) comprises at least one X-ray source, preferably an array of X-ray sources (101a-101d), and an X-ray detector (103) with an array of sensitive pixels (103a-103e). A collimator (102) is arranged between the X-ray source and the detector such that two openings (P) of the collimator (102) allow the passage of X-rays towards two neighboring pixels (103a-103e) while the region between said pixels is substantially shielded. This shielding of the usually insensitive regions between pixels reduces unnecessary X-ray exposure. A sufficiently large X-ray intensity can be achieved by using a plurality of small X-ray sources (101a-101d).

    摘要翻译： 本发明涉及一种用于产生X射线101a 101b 101c 101d图像的方法和成像系统（100）。 系统（100）包括至少一个X射线源，优选X射线源阵列（101a-101d）和具有敏感像素阵列（103a-103e）的X射线检测器（103）。 准直器（102）布置在X射线源和检测器之间，使得准直器（102）的两个开口（P）允许X射线朝向两个相邻像素（103a-103e）通过，而所述准直器 像素基本被屏蔽。 像素之间通常不敏感区域的这种屏蔽减少了不必要的X射线曝光。 通过使用多个小的X射线源（101a-101d）可以获得足够大的X射线强度。

    PHASE CONTRAST IMAGING
    15.
    发明申请
    PHASE CONTRAST IMAGING 有权
    相位对比成像

    公开(公告)号：US20120243658A1

    公开(公告)日：2012-09-27

    申请号：US13514682

    申请日：2010-12-03

    申请人： Dieter Geller ,  Klaus Juergen Engel ,  Gereon Vogtmeier ,  Thomas Koehler ,  Ewald Roessl

    发明人： Dieter Geller ,  Klaus Juergen Engel ,  Gereon Vogtmeier ,  Thomas Koehler ,  Ewald Roessl

    IPC分类号： G01N23/04

    CPC分类号： A61B6/00 ,  A61B6/4291 ,  A61B6/4441 ,  A61B6/484

    摘要： X-ray devices for Phase Contrast Imaging (PCI) are often built up with the help of gratings. For large field-of-views (FOV), production cost and complexity of these gratings could increase significantly as they need to have a focused geometry. Instead of a pure PCI with a large FOV, this invention suggests to combine a traditional absorption X-ray-imaging system with large-FOV with an insertable low-cost PCI system with small-FOV, The invention supports the user to direct the PCI system with reduced FOV to a region that he regards as most interesting for performing a PCI scan thus eliminating X-ray dose exposure for scanning regions not interesting for a radiologist. The PCI scan may be generated on the basis of local tomography.

    摘要翻译： 用于相位对比成像（PCI）的X射线装置通常在光栅的帮助下构建。 对于大视野（FOV）来说，这些光栅的生产成本和复杂性可能会因为需要聚焦几何而显着增加。 本发明不是采用具有大FOV的纯PCI，而是将传统的吸收X射线成像系统与大型FOV结合，并具有小FOV的可插入低成本PCI系统。本发明支持用户指导PCI 系统将FOV降低到他认为对于执行PCI扫描最有趣的区域，从而消除了用于放射科医生不感兴趣的扫描区域的X射线剂量曝光。 可以基于局部断层摄影产生PCI扫描。

    SCANNING SYSTEM FOR DIFFERENTIAL PHASE CONTRAST IMAGING
    16.
    发明申请
    SCANNING SYSTEM FOR DIFFERENTIAL PHASE CONTRAST IMAGING 有权
    扫描系统进行差分相位成像

    公开(公告)号：US20120236992A1

    公开(公告)日：2012-09-20

    申请号：US13514312

    申请日：2010-12-08

    申请人： Klaus Juergen Engel ,  Dieter Geller ,  Gereon Vogtmeier ,  Thomas Koehler

    发明人： Klaus Juergen Engel ,  Dieter Geller ,  Gereon Vogtmeier ,  Thomas Koehler

    IPC分类号： G01N23/04 ,  B82Y99/00

    CPC分类号： A61B6/00 ,  A61B6/032 ,  A61B6/4291 ,  A61B6/484 ,  A61B6/488 ,  A61B6/5241

    摘要： The invention relates to the field of X-ray differential phase contrast imaging. For scanning large objects and for an improved contrast to noise ration, an X-ray device (10) for imaging an object (18) is provided. The X-ray device (10) comprises an X-ray emitter arrangement (12) and an X-ray detector arrangement (14), wherein the X-ray emitter arrangement (14) is adapted to emit an X-ray beam (16) through the object (18) onto the X-ray detector arrangement (14). The X-ray beam (16) is at least partial spatial coherent and fan-shaped. The X-ray detector arrangement (14) comprises a phase grating (50) and an absorber grating (52). The X-ray detector arrangement (14) comprises an area detector (54) for detecting X-rays, wherein the X-ray device is adapted to generate image data from the detected X-rays and to extract phase information from the X-ray image data, the phase information relating to a phase shift of X-rays caused by the object (18). The object (18) has a region of interest (32) which is larger than a detection area of the X-ray detector (18) and the X-ray device (10) is adapted to generate image data of the region of interest (32) by moving the object (18) and the X-ray detector arrangement (14) relative to each other.

    摘要翻译： 本发明涉及X射线差分相位成像领域。 为了扫描大型物体并改善与噪音比较的对比度，提供了用于对物体（18）成像的X射线装置（10）。 X射线装置（10）包括X射线发射器装置（12）和X射线检测器装置（14），其中X射线发射器装置（14）适于发射X射线束（16） ）通过物体（18）到X射线检测器装置（14）上。 X射线束（16）至少部分空间相干和扇形。 X射线检测器装置（14）包括相位光栅（50）和吸收光栅（52）。 X射线检测器装置（14）包括用于检测X射线的区域检测器（54），其中X射线装置适于从检测到的X射线产生图像数据，并从X射线 图像数据，与由对象（18）引起的X射线的相移相关的相位信息。 物体（18）具有大于X射线检测器（18）的检测区域的感兴趣区域（32），并且X射线装置（10）适于产生感兴趣区域的图像数据（ 32）通过相对于彼此移动物体（18）和X射线检测器装置（14）。

    Apparatus for deburring with planing tools a metal strand cut to length by gas cutting
    19.
    发明申请
    Apparatus for deburring with planing tools a metal strand cut to length by gas cutting 有权
    用于通过刨削工具去毛刺的装置，通过气体切割切割成长度的金属线

    公开(公告)号：US20080170922A1

    公开(公告)日：2008-07-17

    申请号：US12006887

    申请日：2008-01-07

    申请人： Hans-Juergen Engel ,  Wolfgang Maly

    发明人： Hans-Juergen Engel ,  Wolfgang Maly

    IPC分类号： B22D11/126 ,  B22D11/12 ,  B23D1/26

    CPC分类号： B23K37/08 ,  B22D11/1265 ,  B23D79/021 ,  B23K7/10 ,  Y10T409/50164 ,  Y10T409/503608 ,  Y10T409/5041 ,  Y10T409/505084

    摘要： An apparatus is described for deburring with planing tools (7) a metal strand (1) cut to length by gas cutting, which planing tools are adjustably held each for themselves transversally to the metal strand (1) in a support (6), and with a drive for the relative advancing movement of the planing tools (7) relative to the metal strand (1) which is cut to length. In order to provide advantageous deburring conditions it is proposed that the annular support (6) comprises at least two sets of planing tools (7) which are radially adjustable to the metal strand (1) cut to length, which sets are arranged behind one another in the longitudinal direction of the metal strand (1) cut to length and which are staggered against each other set by set.

    摘要翻译： 描述了一种用于通过刨削工具（7）去毛刺的装置，其中通过气体切割切割成长度的金属线束（1），其中所述刨切工具可自动地在支撑件（6）中横向地固定到金属绞线（1）;以及 具有用于相对于被切割成长度的金属绞线（1）相对前进的刨刀（7）的运动的驱动。 为了提供有利的去毛刺条件，提出了环形支撑件（6）包括至少两组刨削工具（7），该组刨刀具可径向调节到金属绞线（1）的长度，这些组彼此相对布置 在金属绞线（1）的长度方向上切割成长度并且彼此交错设置。

    NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF
    20.
    发明申请
    NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF 审中-公开
    具有降低细胞毒性的新型碱金属磷酸衍生物及其用途

    公开(公告)号：US20070167408A1

    公开(公告)日：2007-07-19

    申请号：US11612506

    申请日：2006-12-19

    申请人： Daniel PERRISSOUD ,  Mathias Pietras ,  Juergen Engel

    发明人： Daniel PERRISSOUD ,  Mathias Pietras ,  Juergen Engel

    IPC分类号： A61K31/675

    CPC分类号： A61K31/675 ,  Y02A50/463

    摘要： The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.

    摘要翻译： 本发明提供了具有降低的细胞毒性的新型烷基磷脂衍生物，其可用于治疗由微生物特别是细菌，真菌，原生动物和/或病毒引起的哺乳动物，优选人类的各种疾病和/或病理生理条件。 这种烷基磷脂可以作为单一药物使用，也可以在组合疗法中使用，也可用于治疗肿瘤。