摘要:
A radiation detector device for detecting a primary radiation includes a scintillator which generates a converted primary radiation in response to incoming primary radiation and a photo detector for detecting the converted primary radiation. The radiation detector device further includes a secondary radiation source for irradiating the scintillator with a secondary radiation which has a wavelength different from a wavelength of the first radiation and which is capable of producing a spatially more uniform response of the scintillator to primary radiation.
摘要:
The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.
摘要:
The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.
摘要:
The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.
摘要:
A method for providing information about a spatial gain distribution of a scintillator for a primary radiation is provided which does not require the irradiation of the scintillator with the primary radiation. The method comprises the step of irradiating the scintillator with a secondary radiation for generating an image of a spatial secondary gain distribution of the scintillator for said second radiation. The spatial secondary gain distribution image corresponds to an image of the spatial primary gain distribution for the primary radiation. In an embodiment of the invention, i.e. in an X-rayimaging device where the primary radiation is X-rayradiation, the invention provides for an accurate calibration of the X-raydetector without irradiating the X-raydetector with X-rayradiation. Rather, irradiation with UV radiation as the secondary radiation provides the desired spatial secondary gain distribution image which can be used for calibration.
摘要:
A method for manufacturing a photo-responsive device having a photo-sensitive layer is proposed. The method comprises the following steps: a) providing a clean substrate inside an evacuated evaporation chamber; b) evaporating lead oxide (PbO) from a first crucible to form a seeding layer on the surface of the substrate; c) affecting upon the seeding layer such that only tetragonal lead oxide forms the seeding layer and/or such that the initially grown orthorhombic lead oxide forming the seeding layer is transformed into tetragonal lead oxide; and d) continuing to evaporate lead oxide until the final thickness of the photo-sensitive layer has been deposited onto the substrate. As a result the method yields a photo-responsive device comprising a photo-sensitive layer of lead oxide, which entirely consists of tetragonal lead oxide.
摘要:
A detector unit (301) for detecting electromagnetic radiation (106), the detector unit (301) comprising a conversion material (332) adapted for converting impinging electromagnetic radiation (106) into electric charge carriers, a charge collection electrode (331) adapted for collecting the converted electric charge carriers, a shielding electrode (334, 335) adapted to form a capacitance with the charge collection electrode (331), and an evaluation circuit (312 to 315) electrically coupled with the charge collection electrode (331) and adapted for evaluating the electromagnetic radiation (106) based on the collected electric charge carriers.
摘要:
The application describes an X-ray detector, which uses direct X-ray conversion (DiCo) combined with CMOS pixel circuits. DiCo materials have to be used with high voltage to achieve a high field strength. This makes the sensor prone to leakage currents, which falsify the measured charge result. Moreover, most direct conversion materials suffer from large residual signals that lead to temporal artifacts (ghost images) in an X-ray image sequence. A circuit is described, which senses the sensor's dark current including residual signals from previous exposures before the sensor is exposed (again) to X-ray, and freezes relevant circuit parameters at the end of the sensing phase in such way, that the dark current (leakage current and residual signal) can still be drained during exposure. Therefore, the charge pulses generated in the sensor due to X-ray exposure can be integrated without charges carried by the leakage current or residual signal, thus obtaining a more accurate estimate of the deposited X-ray energy.
摘要:
The invention relates to a detector and a method for the production of consecutive X-ray images. This involves the generation in the detector by X-radiation during an exposure interval (Texp) of a current flow (I(t)) which is integrated (Qdk*, Qsig*, Qac*) in a memory capacity and read out in a subsequent readout phase (Trd). In order to minimize the influence of slowly decaying residual currents (Iac), the current (I(t)) is integrated only during the exposure interval (Texp). By this means, disturbing artifacts due to residual signals from earlier photographs are minimized.
摘要:
According to an exemplary embodiment of the invention a detector unit 301 for detecting electro-magnetic radiation may be provided. The detector unit 301 may comprise a conversion material 332 adapted for converting impinging electro-magnetic radiation into electric charge carriers. Moreover, the detector unit 301 may comprise a charge collection electrode 331 adapted for collecting the converted electric 321 charge carriers and an evaluation circuit 312, 313, 314 adapted for evaluating the electro-magnetic radiation based on the collected electric charge carriers. Moreover, the detector unit 301 may comprise a semiconductor 373 which may be electrically coupled between the charge 331 collection electrode 331 and the evaluation circuit 312, 313, 314.