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11.发明授权Antigen constructs useful in the detection and differentiation of antibodies to HIV 有权用于检测和分化HIV抗体的新型抗原构建体公开(公告)号：US07615613B2
公开(公告)日：2009-11-10
申请号：US11954351
申请日：2007-12-12
申请人： John R. Hackett , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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12.发明授权Antigen constructs useful in the detection and differentiation of antibodies to HIV 失效用于HIV抗体检测和分化的抗原构建体公开(公告)号：US06846905B2
公开(公告)日：2005-01-25
申请号：US08911824
申请日：1997-08-15
申请人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
IPC分类号： G01N33/53 , A61K39/00 , C07K14/155 , C07K14/16 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/49 , C07K14/15
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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13.发明授权Antigen constructs useful in the detection and differentiation of antibodies to HIV 失效用于HIV抗体检测和分化的抗原构建体公开(公告)号：US08785596B2
公开(公告)日：2014-07-22
申请号：US12973384
申请日：2010-12-20
申请人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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14.发明授权Antigen constructs useful in the detection and differentiation of antibodies to HIV 有权用于HIV抗体检测和分化的抗原构建体公开(公告)号：US07883845B2
公开(公告)日：2011-02-08
申请号：US12574407
申请日：2009-10-06
申请人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
IPC分类号： C12Q1/70 , C07K14/005 , C07K14/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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15.发明申请Novel Antigen Constructs Useful In the Detection and Differentiation of Antibodies to HIV 有权用于HIV抗体检测和分化的新型抗原构建体公开(公告)号：US20080090994A1
公开(公告)日：2008-04-17
申请号：US11954351
申请日：2007-12-12
申请人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
发明人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
IPC分类号： C07K16/00
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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公开(公告)号：US5854001A
公开(公告)日：1998-12-29
申请号：US710637
申请日：1996-09-18
申请人： James M. Casey , Suzanne L. Bode , Billy J. Zeck , Julie Yamaguchi , Donald E. Frail , Suresh M. Desai , Sushil G. Devare
发明人： James M. Casey , Suzanne L. Bode , Billy J. Zeck , Julie Yamaguchi , Donald E. Frail , Suresh M. Desai , Sushil G. Devare
IPC分类号： C12N15/09 , A61K38/00 , C07K14/18 , C07K16/00 , C07K16/10 , C07K19/00 , C12P21/02 , C12P21/08 , C12Q1/70 , C12R1/91 , G01N33/53 , C07K2/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222
摘要： Mammalian expression systems for the production of HCV fusion proteins. Such expression systems provide high yields of HCV fusion proteins, and enable the development of diagnostic and therapeutic reagents which contain glycosylated structural antigens and also allow for the isolation of the HCV etiological agent.
摘要翻译： 用于生产HCV融合蛋白的哺乳动物表达系统。 这种表达系统提供高产量的HCV融合蛋白，并且能够开发含有糖基化结构抗原的诊断和治疗试剂，并且还允许分离HCV病原体。
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