公开(公告)号：US20210318277A1

公开(公告)日：2021-10-14

申请号：US17283716

申请日：2019-10-11

申请人： KAGAMI INC.

发明人： Tatsuhiko IKEDA ,  Masashi MlTA

IPC分类号： G01N30/86 ,  G01N30/74 ,  G06T7/00 ,  G06T7/50

摘要： An analysis method for data generated by at least two parameters is provided. The method includes a comparison step of making a comparison between a data shape of a target component in a measurement sample and a standard shape acquired in advance, and a step of identifying the target component in the measurement sample based on the comparison.

公开(公告)号：US11099191B2

公开(公告)日：2021-08-24

申请号：US16302226

申请日：2017-05-17

申请人： Osaka University ,  Kagami Inc.

发明人： Yoshitaka Isaka ,  Tomonori Kimura ,  Keiko Yasuda ,  Kenji Hamase ,  Masashi Mita

IPC分类号： G01N33/68 ,  G01N33/72

摘要： The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

公开(公告)号：US20240145091A1

公开(公告)日：2024-05-02

申请号：US18488380

申请日：2023-10-17

申请人： National Institutes of Biomedical Innovation, Health and Nutrition ,  Kagami Inc.

发明人： Tomonori KIMURA ,  Shihoko KIMURA ,  Yasuhiro YASUTOMI ,  Masamitsu ASAKA ,  Emiko URANO ,  Daichi UTSUMI ,  Masashi MITA

IPC分类号： G16H50/20 ,  A61K31/198 ,  A61K31/401 ,  A61P31/12 ,  G16H20/10

CPC分类号： G16H50/20 ,  A61K31/198 ,  A61K31/401 ,  A61P31/12 ,  G16H20/10

摘要： Provided herein is a method for modulating the amount of virus in a subject comprising administering to the subject an agent for controlling an indicator associated with a D-amino acid in the subject.

公开(公告)号：US10852308B2

公开(公告)日：2020-12-01

申请号：US15580855

申请日：2016-06-10

申请人： Kanazawa University ,  Kagami Inc.

发明人： Takashi Wada ,  Kengo Furuichi ,  Norihiro Sakai ,  Yasunori Iwata ,  Akinori Hara ,  Yusuke Nakade ,  Kenji Hamase ,  Yurika Miyoshi ,  Maiko Nakane ,  Masashi Mita

IPC分类号： G01N33/00 ,  G01N33/68

摘要： The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.

公开(公告)号：US20240238236A1

公开(公告)日：2024-07-18

申请号：US18561927

申请日：2022-05-19

申请人： KAGAMI INC. ,  NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY

发明人： Takashi WADA ,  Norihiko SAKAI ,  Yasunori IWATA ,  Yusuke NAKADE ,  Taku KOBAYASHI ,  Masashi MITA

IPC分类号： A61K31/198 ,  A61K31/519 ,  A61P3/10

CPC分类号： A61K31/198 ,  A61K31/519 ,  A61P3/10

摘要： The present invention provides a composition for regulating carbohydrate metabolism, the composition containing, as an active ingredient, an agent for controlling the amount of D-amino acid in the living body of a subject. Moreover, the present invention provides a method for assessing carbohydrate metabolism conditions of a subject by monitoring the amount of D-amino acid in the living body of the subject.

公开(公告)号：US20220170945A1

公开(公告)日：2022-06-02

申请号：US17442069

申请日：2020-03-23

申请人： Kagami Inc. ,  National Institutes of Biomedical, Innovation, Health and Nutrition

发明人： Masashi MITA ,  Tatsuhiko IKEDA ,  Tomonori KIMURA

IPC分类号： G01N33/68 ,  G01N33/70

摘要： The present invention provides: a method for assisting the evaluation of renal pathological conditions, said method comprising using, as an index, a combination of renal reabsorption and excretion ratios of D-serine and/or D-asparagine in a subject with the blood D-serine and/or D-asparagine levels; a system for evaluating renal pathological conditions; and a program for evaluating renal pathological conditions. The present invention also provides: a method for monitoring renal pathological conditions; and a method for monitoring an effect of treating a renal disease.

公开(公告)号：US20210220309A1

公开(公告)日：2021-07-22

申请号：US16972898

申请日：2019-06-06

申请人： National University Corporation Kanazawa University ,  Kagami Inc.

发明人： Takashi WADA ,  Kengo FURUICHI ,  Norihiko SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Masashi MITA

IPC分类号： A61K31/198 ,  A61P13/12 ,  A61K9/00

摘要： The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, a kidney inflammation inhibitor, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-alanine or a derivative thereof. In addition, the present invention pertains to the use of D-alanine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.

公开(公告)号：US10753911B2

公开(公告)日：2020-08-25

申请号：US15555862

申请日：2016-05-10

申请人： KAGAMI INC.

发明人： Kenji Hamase ,  Shoto Ishigo ,  Yurika Miyoshi ,  Tadashi Ueda ,  Masashi Mita

IPC分类号： G01N30/06 ,  G01N30/88 ,  G01N30/74 ,  G01N30/78 ,  G01N33/68 ,  G01N30/86 ,  G01N30/72

摘要： A chiral analysis method of a bound amino acid includes a step of hydrolyzing a bound amino acid using a deuterium chloride-deuterium oxide solution and/or deuterium oxide; a step of separating, by chiral separation, a D-form and an L-form of an amino acid generated by the hydrolyzation; a step of generating fragments from the separated amino acid; and a step of selecting and analyzing a predetermined fragment that contains an α carbon and does not contain a side chain from the generated fragments, by mass spectrometry.