-
公开(公告)号：US20210373030A1
公开(公告)日：2021-12-02
申请号：US17286355
申请日：2019-10-17
发明人： Masashi MITA , Takashi WADA , Kengo FURUICHI , Norihiko SAKAI , Yasunori IWATA , Shinji KITAJIMA , Yusuke NAKADE
摘要： The present invention provides: a marker for determining critical stage kidney disease by using an indicator value based on the amount of D-alanine in the blood or the amount of D-alanine and L-alanine therein; a blood analysis method which uses said marker for patients undergoing surgery or intensive care; and a blood analysis system for determining critical stage kidney disease in patients undergoing surgery or intensive care.
-
公开(公告)号：US20210283082A1
公开(公告)日：2021-09-16
申请号：US16972906
申请日：2019-06-06
发明人： Takashi WADA , Kengo FURUICHI , Norihiko SAKAI , Yasunori IWATA , Akinori HARA , Yusuke NAKADE , Kenji HAMASE , Masashi MITA
IPC分类号： A61K31/198 , A61P13/12 , A61K9/00
摘要： The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, an inflammation inhibitor for the kidneys, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-serine or a derivative thereof. In addition, the present invention pertains to the use of D-serine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.
-
3.发明公开公开(公告)号：US20240238236A1
公开(公告)日：2024-07-18
申请号：US18561927
申请日：2022-05-19
发明人： Takashi WADA , Norihiko SAKAI , Yasunori IWATA , Yusuke NAKADE , Taku KOBAYASHI , Masashi MITA
IPC分类号： A61K31/198 , A61K31/519 , A61P3/10
CPC分类号： A61K31/198 , A61K31/519 , A61P3/10
摘要： The present invention provides a composition for regulating carbohydrate metabolism, the composition containing, as an active ingredient, an agent for controlling the amount of D-amino acid in the living body of a subject. Moreover, the present invention provides a method for assessing carbohydrate metabolism conditions of a subject by monitoring the amount of D-amino acid in the living body of the subject.
-
公开(公告)号：US20210220309A1
公开(公告)日：2021-07-22
申请号：US16972898
申请日：2019-06-06
发明人： Takashi WADA , Kengo FURUICHI , Norihiko SAKAI , Yasunori IWATA , Akinori HARA , Yusuke NAKADE , Kenji HAMASE , Masashi MITA
IPC分类号： A61K31/198 , A61P13/12 , A61K9/00
摘要： The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, a kidney inflammation inhibitor, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-alanine or a derivative thereof. In addition, the present invention pertains to the use of D-alanine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.
-
5.发明公开公开(公告)号：US20230220387A1
公开(公告)日：2023-07-13
申请号：US17789399
申请日：2020-12-25
申请人： Kagami Inc. , Public University Corporation Nara Medical University , National Institutes of Biomedical Innovation, Health and Nutrition
发明人： Masashi MITA , Rikako SUZUKI , Shushi NAGAMORI , Pattama WIRIYASERMKUL , Pornparn KONGPRACHA , Satomi MORIYAMA , Tomonori KIMURA
IPC分类号： C12N15/113 , A61K31/192 , A61K31/616 , A61K31/465 , A61K31/198 , A61K31/197
CPC分类号： C12N15/113 , A61K31/192 , A61K31/616 , A61K31/465 , A61K31/198 , A61K31/197 , C12N2310/14
摘要： The present invention provides a D-serine transport modifier which is characterized by controlling the transport of D-serine into and out of cells by a D-serine transporter protein, a pharmaceutical composition which comprises the same as an active component and treats or prevents diseases relating to an increase or decrease in the amount of D-serine, and a screening method of substances that control the transport of D-serine. The present invention also provides a screening method of a D-serine transporter protein.
-
公开(公告)号：US20240145091A1
公开(公告)日：2024-05-02
申请号：US18488380
申请日：2023-10-17
发明人： Tomonori KIMURA , Shihoko KIMURA , Yasuhiro YASUTOMI , Masamitsu ASAKA , Emiko URANO , Daichi UTSUMI , Masashi MITA
IPC分类号： G16H50/20 , A61K31/198 , A61K31/401 , A61P31/12 , G16H20/10
CPC分类号： G16H50/20 , A61K31/198 , A61K31/401 , A61P31/12 , G16H20/10
摘要： Provided herein is a method for modulating the amount of virus in a subject comprising administering to the subject an agent for controlling an indicator associated with a D-amino acid in the subject.
-
公开(公告)号：US20220003774A1
公开(公告)日：2022-01-06
申请号：US17374777
申请日：2021-07-13
申请人： Osaka University , Kagami Inc.
发明人： Yoshitaka ISAKA , Tomonori KIMURA , Keiko YASUDA , Kenji Hamase , Masashi MITA
摘要： The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.
-
公开(公告)号：US20220170945A1
公开(公告)日：2022-06-02
申请号：US17442069
申请日：2020-03-23
发明人： Masashi MITA , Tatsuhiko IKEDA , Tomonori KIMURA
摘要： The present invention provides: a method for assisting the evaluation of renal pathological conditions, said method comprising using, as an index, a combination of renal reabsorption and excretion ratios of D-serine and/or D-asparagine in a subject with the blood D-serine and/or D-asparagine levels; a system for evaluating renal pathological conditions; and a program for evaluating renal pathological conditions. The present invention also provides: a method for monitoring renal pathological conditions; and a method for monitoring an effect of treating a renal disease.
-
9.发明公开公开(公告)号：US20240127956A1
公开(公告)日：2024-04-18
申请号：US18488373
申请日：2023-10-17
申请人： Osaka University , National Institutes of Biomedical Innovation, Health and Nutrition , Kagami Inc.
发明人： Yoshitaka ISAKA , Tomonori KIMURA , Shihoko KIMURA , Masashi MITA
CPC分类号： G16H50/20 , G01N33/6893 , G16H20/10 , G01N2800/52
摘要： Provided herein is a method for providing information about virus infection and/or virus infection disease in a subject, comprising: making a determination on the detection and/or stage classification of virus infection and/or virus infection disease in the subject using an indicator associated with a D-amino acid in the subject; and providing information about virus infection and/or virus infection disease in the subject based on the results of the determination.
-
公开(公告)号：US20230037869A1
公开(公告)日：2023-02-09
申请号：US17789402
申请日：2020-12-25
发明人： Masashi MITA , Tatsuhiko IKEDA , Tomonori KIMURA
摘要： The present invention provides a method comprising a step of estimating the kidney function of an arbitrary subject by a regression analysis which employs the amount of a D, L-amino acid in a biological sample from the arbitrary subject as an explanatory variable and employs the amount of filtrated glomeruli in the arbitrary subject as an object variable, by employing a previously determined formula (I): Y=a1·X1+a2·X2+ . . . +an·Xn+b (I) [wherein a1 to an independently represent a constant obtained by the regression analysis; X1 to Xn independently represent a variable of the amount of the D,L-amino acid which is selected by the regression analysis; and b represents a constant obtained by the regression analysis] on the basis of the Y value calculated from the amount of the D, L-amino acid in the biological sample from the object to be evaluated. Also provided is a system for carrying out the method.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.021 秒)
