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    Process for producing hydroxyarenes
    13.
    发明授权
    Process for producing hydroxyarenes 失效
    生产羟基芳烃的方法

    公开(公告)号：US06172225B2

    公开(公告)日：2001-01-09

    申请号：US09180777

    申请日：1998-11-12

    Applicant: Karl-Heinz Linker ,  Wilhelm Haas ,  Otto Schallner ,  Kurt Findeisen ,  Roland Andree ,  Mark Wilhelm Drewes

    Inventor： Karl-Heinz Linker ,  Wilhelm Haas ,  Otto Schallner ,  Kurt Findeisen ,  Roland Andree ,  Mark Wilhelm Drewes

    IPC: C07D23902

    CPC classification number: C07D239/54 ,  C07C37/02 ,  C07C253/30 ,  C07D231/16 ,  C07C39/06

    Abstract: The invention relates to a novel process for producing thereof hydroxyarenes of the general formula (I) in which n represents the numbers 1, 2, 3 or 4, R represents cyano, carboxyl, formyl, nitro, halogen or represents alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylcarbonyl or alkoxycarbonyl, each of which is optionally substituted, and Z represents hydrogen, cyano, nitro, halogen, alkyl, halogenoalkyl, or represents monocyclic or bicyclic, saturated or unsaturated heterocyclyl, heterocyclylamino or heterocyclylimino, each of which is optionally substituted, characterized in that halogenoarenes of the general formula (II) in which n, R and Z are each as defined above and X represents halogen are reacted with 3-hydroxy-propionitrile of the formula (III), HO—CH2CH2—CN  (III), if appropriate in the presence of a reaction auxiliary and if appropriate in the presence of a diluent, at temperatures between 0° C. and 100° C.

    Abstract translation: 本发明涉及一种制备通式（I）的羟基芳烃的新方法，其中n代表数字1,2,3或4，R代表氰基，羧基，甲酰基，硝基，卤素或代表烷基，烷氧基，烷硫基， 烷基亚磺酰基，烷基磺酰基，烷基羰基或烷氧基羰基，其各自任选被取代，Z表示氢，氰基，硝基，卤素，烷基，卤代烷基，或表示单环或双环饱和或不饱和的杂环基，杂环基氨基或杂环基， 其特征在于通式（Ⅱ）的卤代芳烃，其中，R和Z各自如上所定义，X代表卤素与式（III）的3-羟基 - 丙腈反应，如果合适，在反应助剂和 如果在稀释剂存在的情况下适当，在0℃至100℃的温度下

    Method for the production of 1-amino-3-phenyluracil derivatives
    18.
    发明授权
    Method for the production of 1-amino-3-phenyluracil derivatives 失效

    公开(公告)号：US07034156B2

    公开(公告)日：2006-04-25

    申请号：US10476941

    申请日：2002-04-25

    Applicant: Jörn Stölting ,  Dorothee Hoischen ,  Roland Andree ,  Karl-Heinz Linker ,  Holger Weintritt ,  Heinz-Jürgen Wroblowsky

    Inventor： Jörn Stölting ,  Dorothee Hoischen ,  Roland Andree ,  Karl-Heinz Linker ,  Holger Weintritt ,  Heinz-Jürgen Wroblowsky

    IPC: C07D239/54

    CPC classification number: C07D239/22 ,  C07D239/54

    Abstract: The present invention relates to a novel process for preparing known 1-amino-3-phenyluracil derivatives, to novel 1-amino-6-hydroxy-3-phenyldihydro-2,4(1H,3H)pyrimidinedione derivatives of the formula (II) in which R1 is hydrogen, cyano, nitro or halogen, R2 is cyano, nitro, halogen or optionally substituted alkyl or alkoxy, R3 is hydrogen, hydroxyl, mercapto, amino, hydroxyamino, hydrazino, halogen, or one of the radicals —R6, -Q-R6, —NH—R6, —NH—O—R6, —NH—SO2—R6, —N(SO2—R6)2, —CQ1-R6, —CQ1-Q2-R6, —CQ1-NH—R6, -Q2-CQ1-R6, —NH—CQ1-R6, —N(SO2—R6)(CQ1-R6), -Q2-CQ1-Q2-R6, —NH—CQ1-Q2-R6 or -Q2-CQ1-NH—R6, where Q is O, S, SO or SO2, Q1 and Q2 are each independently oxygen or sulphur and R6 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, R4 is hydrogen, halogen or optionally substituted alkyl, and R5 is fluorine- and/or chlorine-substituted alkyl, as intermediates for the 1-amino-3-phenyluracil derivatives, and to a process for preparing the intermediates.

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