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    Molecules of the card-related protein family and uses thereof
    11.
    发明授权
    Molecules of the card-related protein family and uses thereof 失效
    卡相关蛋白家族的分子及其用途

    公开(公告)号：US07083944B1

    公开(公告)日：2006-08-01

    申请号：US09697089

    申请日：2000-10-26

    Applicant: John Bertin ,  Keith E. Robison

    Inventor： John Bertin ,  Keith E. Robison

    IPC: C07K14/47 ,  C12N15/12 ,  C12N15/63 ,  C12N1/00 ,  C12N5/10

    CPC classification number: C07K14/4702 ,  A61K38/00

    Abstract: Novel CARD-12 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-12 proteins, the invention further provides CARD-12, fusion proteins, antigenic peptides and anti-CARD-12 antibodies. The invention also provides CARD-12 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-12 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    Abstract translation: 公开了新型CARD-12多肽，蛋白质和核酸分子。 除了分离的CARD-12蛋白之外，本发明还提供了CARD-12，融合蛋白，抗原肽和抗CARD-12抗体。 本发明还提供CARD-12核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了CARD-12基因的非人转基因动物，或 中断了 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Angiotensin converting enzyme homolog and uses therefor
    12.
    发明授权
    Angiotensin converting enzyme homolog and uses therefor 有权
    血管紧张素转换酶同源物及其用途

    公开(公告)号：US06884771B1

    公开(公告)日：2005-04-26

    申请号：US09635501

    申请日：2000-08-09

    Applicant: Susan Acton ,  Keith E. Robison ,  Frank Y. Hsieh

    Inventor： Susan Acton ,  Keith E. Robison ,  Frank Y. Hsieh

    IPC: A61K38/00 ,  A61K38/48 ,  C12N9/48 ,  C12N15/12 ,  A51K38/00

    CPC classification number: A61K38/4813 ,  C12N9/48 ,  C12Y304/15001

    Abstract: The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.

    Abstract translation: 本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。 本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。 还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

    Protease homologs
    13.
    发明授权
    Protease homologs 失效
    蛋白酶同源物

    公开(公告)号：US06331427B1

    公开(公告)日：2001-12-18

    申请号：US09280116

    申请日：1999-03-26

    Applicant: Keith E. Robison

    Inventor： Keith E. Robison

    IPC: C12N964

    CPC classification number: C12N9/6421

    Abstract: The invention relates to polynucleotides encoding newly identified protease homologs belonging to the superfamily of G-protein-coupled proteases. The invention also relates to the proteases. The invention further relates to methods using the protease polypeptides and polynucleotides as a target for diagnosis and treatment in protease-mediated disorders. The invention further relates to drug-screening methods using the protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the protease polypeptides and polynucleotides. The invention further relates to procedures for producing the protease polypeptides and polynucleotides.

    Abstract translation: 本发明涉及编码属于G蛋白偶联蛋白酶超家族的新鉴定的蛋白酶同系物的多核苷酸。 本发明还涉及蛋白酶。 本发明还涉及使用蛋白酶多肽和多核苷酸作为在蛋白酶介导的病症中进行诊断和治疗的靶标的方法。 本发明还涉及使用蛋白酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于蛋白酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生蛋白酶多肽和多核苷酸的方法。

    Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor
    16.
    发明授权
    Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor 失效
    编码人类激酶和磷酸酶同系物的核酸分子及其用途

    公开(公告)号：US06465232B1

    公开(公告)日：2002-10-15

    申请号：US09948802

    申请日：2001-09-07

    Applicant: Keith E. Robison

    Inventor： Keith E. Robison

    IPC: C12N912

    CPC classification number: G01N33/573 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/12 ,  C12N9/16 ,  G01N2333/9121 ,  G01N2500/00

    Abstract: The invention provides isolated nucleic acids molecules, designated Kinase and Phosphatase nucleic acid molecules, which encode novel protein kinase and protein phosphatase polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing Kinase and Phosphatase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a Kinase and Phosphatase gene has been introduced or disrupted. The invention still further provides isolated Kinase and Phosphatase proteins, fusion proteins, antigenic peptides and anti-Kinase and Phosphatase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    Abstract translation: 本发明提供编码新的蛋白激酶和蛋白磷酸酶多肽的分离的核酸分子，命名为激酶和磷酸酶核酸分子。 本发明还提供反义核酸分子，含有激酶和磷酸酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了激酶和磷酸酶基因的非人类转基因动物。 本发明还进一步提供了分离的激酶和磷酸酶蛋白，融合蛋白，抗原肽和抗激酶和磷酸酶抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

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