摘要:
This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency. Also, this invention also combines open loop injection control with closed loop injection control to obtain enhanced engine performance, which includes extension of the stable combustion zone.
摘要:
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.
摘要:
The present invention is directed to compounds of Formula I: wherein X is O, S or NR7 and R1-R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.
摘要:
The present invention relates to the purification of proteins, to the products of such purification, and to DNA probes constructed therefrom. More specifically, the invention relates to the purification and sequencing of murine and human colony stimulating factor-1 (CSF-1).
摘要:
An improved method and apparatus for actively controlling a combustion process such as a waste incinerator by means of a spatial and temporal synchronized injection of fuel. The improved method and apparatus employs an active control system which controls the intentional formation of large scale, coherent vortices and the synchronized injection of the fuel supply at various locations relative to the formation of the vortices. The preferred apparatus comprises an actuator or similar structure that is adapted for producing and stabilizing discrete, large scale vortices in a combustion device. In addition, another device controls or modulates the injection of the fuel into the vortices at the optimal location and timing relative to the vortex cycle. As applied to an incinerator, this method can be optimized to ensures that the fuel and waste are introduced into the highest temperature locations, were extended residence times are obtained by trapping the fuel and waste inside the vortices. A high combustion efficiency may also be achieved by actively synchronizing the periodic fuel injection with the formation of the vortices.
摘要:
The oscillations found to occur in the cavities of an structural frame moving through a fluid are substantially eliminated by the adoption of perturbation elements located at the leading edge of the cavity and reflecting any remaining oscillations out of the cavity at the trailing edge. The perturbation elements may take the form of multiple pins of various shape and geometrical arrangement which prevents the generation and growth of vortices causing acoustic oscillations. The reflection of remaining oscillations out of the cavity may be accomplished by ramping the trailing edge of the cavity.
摘要:
A punch has a punch tip with a shank and a punch pad with an orifice for receiving the shank. The punch pad includes a hole positioned closely adjacent the orifice to define a thin wall between the hole and the orifice. The thin wall has a slot which extends through its thickness to define at least one, and preferably two, tabs. An insert, which may be a pin, is provided for insertion into the hole and deforming the tab into supportive, retaining contact with the shank of the punch tip within the orifice. The shank of the punch tip may be provided with a shoulder for abutting the inwardly deformed tab or tabs to restrain withdrawal of the punch tip from the punch pad during operation.
摘要:
The invention is directed to a fluid mixing device in which a jet of firstluid is passed through a nozzle having a conical inlet section and a noncircular, elongated, exit section. The jet of first fluid mixes with a second fluid located downstream of the device. In operation, the intersection of the conical and elongated sections produces axial rotation in the first fluid. Intense, three-dimensional, axial and circumferential vortical structures are created. These structures then interact with the high modes of azimuthal instabilities that are common to the elongated configuration. The jet of first fluid evolves into two secondary jets, generating a double shear layer inside the flow. Highly efficient mixing of the fluids, in both the outside and inside (core) segments of the jet, is achieved within a relatively small mixing space.
摘要:
A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要:
The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.