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公开(公告)号:US06640549B1
公开(公告)日:2003-11-04
申请号:US10421186
申请日:2003-04-24
IPC分类号: F02C500
CPC分类号: F02C5/00 , F02K7/02 , F05D2260/96 , F23M20/005 , F23R2900/00013 , F23R2900/03281
摘要: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency. Also, this invention also combines open loop injection control with closed loop injection control to obtain enhanced engine performance, which includes extension of the stable combustion zone.
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公开(公告)号:US06530228B2
公开(公告)日:2003-03-11
申请号:US09853930
申请日:2001-05-07
IPC分类号: F02C928
CPC分类号: F23R3/00 , F02C5/00 , F02C9/28 , F05D2220/10 , F05D2260/96 , F23K2900/05003 , F23M20/005 , F23N1/002 , F23N5/16 , F23N2041/20 , F23R2900/00013 , F23R2900/00014 , F23R2900/03281 , Y02T50/677
摘要: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency. Also, this invention also combines open loop injection control with closed loop injection control to obtain enhanced engine performance, which includes extension of the stable combustion zone.
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公开(公告)号:US06601393B2
公开(公告)日:2003-08-05
申请号:US10308985
申请日:2002-12-03
IPC分类号: F02C500
CPC分类号: F23R3/00 , F02C5/00 , F02C9/28 , F05D2220/10 , F05D2260/96 , F23K2900/05003 , F23M20/005 , F23N1/002 , F23N5/16 , F23N2041/20 , F23R2900/00013 , F23R2900/00014 , F23R2900/03281 , Y02T50/677
摘要: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency. Also, this invention also combines open loop injection control with closed loop injection control to obtain enhanced engine performance, which includes extension of the stable combustion zone.
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公开(公告)号:US06446427B1
公开(公告)日:2002-09-10
申请号:US09618412
申请日:2000-07-18
申请人: Kenneth Yu , Klaus C. Schadow , Kenneth Wilson , Timothy Parr
发明人: Kenneth Yu , Klaus C. Schadow , Kenneth Wilson , Timothy Parr
IPC分类号: C06D500
CPC分类号: F02K7/105 , F02K9/26 , F05D2260/96 , F05D2260/962
摘要: The present invention relates to a method and device for controlling the solid fuel regression rate of a solid fuel ramjet engine. In a preferred embodiment of the present invention, pressure oscillations are excited using active, closed-loop control to vary the heat transfer, and in turn the regression rate of a solid fuel ramjet engine. The pressure oscillations are excited by introducing small disturbances into the shear layer. The disturbances are amplified in the shear layer and excite pressure oscillations. The disturbances are introduced at a certain phase relative to the pressure oscillations. This is accomplished by closed-loop control. By varying the phase, the amplitude of the pressure oscillations can also be varied, which in turn will vary the heat transfer, regression rate, and thrust level.
摘要翻译: 本发明涉及一种用于控制固体燃料冲压式喷气发动机的固体燃料回收率的方法和装置。 在本发明的一个优选实施例中,使用主动闭环控制来激发压力振荡,以改变传热,并且进而改变固体燃料冲压式喷气发动机的回归率。 通过在剪切层中引入小的扰动来激发压力振荡。 扰动在剪切层中被放大并且激发压力振荡。 在相对于压力振荡的某一阶段引入干扰。 这是通过闭环控制实现的。 通过改变相位,压力振荡的幅度也可以变化,这反过来将改变传热,回归率和推力水平。
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公开(公告)号:US20110301211A1
公开(公告)日:2011-12-08
申请号:US13139260
申请日:2009-12-15
申请人: John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人: John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号: A61K31/42 , C07D413/10 , A61K31/422 , A61P1/16 , A61P17/00 , A61P35/00 , A61P9/00 , A61P11/00 , A61P29/00 , A61P1/00 , A61P13/12 , A61P13/02 , A61P13/00 , A61P1/18 , A61P9/10 , A61P7/04 , A61P11/06 , A61P35/02 , A61P35/04 , A61P27/02 , C07D261/14
CPC分类号: C07D261/14 , C07D413/10
摘要: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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公开(公告)号:US08440707B2
公开(公告)日:2013-05-14
申请号:US13092860
申请日:2011-04-22
申请人: John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人: John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号: A61K31/42 , A61K31/422 , A61P35/00
CPC分类号: C07D261/14 , C07D413/10
摘要: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译: 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物,以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号:US08058300B2
公开(公告)日:2011-11-15
申请号:US12793440
申请日:2010-06-03
申请人: John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人: John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号: A61K31/42 , C07D261/14
CPC分类号: A61K31/42 , C07D261/14
摘要: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译: 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物,以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号:US08383654B2
公开(公告)日:2013-02-26
申请号:US13129078
申请日:2009-11-16
申请人: John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Brian Andrew Stearns , Timothy Parr
发明人: John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Brian Andrew Stearns , Timothy Parr
IPC分类号: A61K31/4245 , A61K31/4155 , A61K31/415 , C07D231/12 , C07D271/06 , C07D403/06
CPC分类号: C07D403/06 , A61K31/4174 , A61K31/4178 , C07D231/12 , C07D271/06
摘要: Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译: 本文描述的是作为PGD 2受体拮抗剂的杂芳基化合物。 还描述了包括所述杂芳基化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸,心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号:US20120015991A1
公开(公告)日:2012-01-19
申请号:US13246746
申请日:2011-09-27
申请人: John Howard HUTCHINSON , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人: John Howard HUTCHINSON , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号: A61K31/4245 , C07D413/10 , A61K31/42 , A61K31/422 , A61P11/06 , A61P35/02 , A61P13/12 , A61P35/00 , A61P35/04 , A61P9/10 , A61P29/00 , A61P9/00 , C07D261/14 , A61P11/00
CPC分类号: A61K31/42 , C07D261/14
摘要: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译: 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物,以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号:US08049015B2
公开(公告)日:2011-11-01
申请号:US12568571
申请日:2009-09-28
申请人: John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Jill Melissa Scott , Brian Andrew Stearns , Yen Pham Truong , Deborah Volkots , Timothy Parr
发明人: John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Jill Melissa Scott , Brian Andrew Stearns , Yen Pham Truong , Deborah Volkots , Timothy Parr
IPC分类号: C07D213/00 , C07D211/72 , C07D211/78 , A61K31/44
CPC分类号: C07D213/55 , C07D213/56 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/89 , C07D401/10 , C07D401/12
摘要: Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译: 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物,以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸,心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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