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公开(公告)号：US20060131494A1
公开(公告)日：2006-06-22
申请号：US11285224
申请日：2005-11-22
Applicant: David Grier , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
Inventor： David Grier , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
CPC classification number: G03H1/08 , G03H1/22 , G03H1/2249 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T428/12486
Abstract: Holographic optical traps using the forces exerted by computer-generated holograms to trap, move and otherwise transform mesoscopically textured materials. The efficacy of the present invention is based upon the quality and nature of the diffractive optical element used to create the traps and dynamically use them. Further a landscape of potential energy sites can be created and used to manipulate, sort and process objects.
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公开(公告)号：US20130202657A1
公开(公告)日：2013-08-08
申请号：US13697692
申请日：2011-05-20
Applicant: Kosta Ladavac , Rodrigo E. Guerra , David Kaz , Vinothan Manoharan , Jens B. Rieger , Roland S. Koltzenburg , David A. Weitz
Inventor： Kosta Ladavac , Rodrigo E. Guerra , David Kaz , Vinothan Manoharan , Jens B. Rieger , Roland S. Koltzenburg , David A. Weitz
IPC: A61K9/12
Abstract: The present invention generally relates to foams and, in particular, to foams for applications such as drug delivery, and particles that are made from such foams. One aspect relates to foams or particles containing pharmaceutically active agents. The foam may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foam or particle has an unexpectedly high specific surface area. A high specific surface area may, in some cases, facilitate delivery or release of the pharmaceutically active agent when the foam or particles made from the foam (e.g., by milling) are administered to a subject. The foam may also exhibit a relatively high loading of the pharmaceutically active agent. In some cases, the foam may be a microcellular foam. In one set of embodiments, the foam is created using a supercritical fluid, such as supercritical C02. For example, a precursor to the foam, containing a pharmaceutically active agent, may be mixed with a foaming agent, then the pressure decreased to cause the foaming agent to expand, thereby causing a foam to form. The foam may then be subsequently ground or milled, or otherwise processed to form particles.
Abstract translation: 本发明一般涉及泡沫，特别是泡沫用于例如药物递送的泡沫，以及由这种泡沫制成的颗粒。 一个方面涉及含有药物活性剂的泡沫或颗粒。 泡沫可以包含药学上可接受的聚合物载体。 在一些情况下，泡沫或颗粒具有出乎意料的高比表面积。 在一些情况下，当由泡沫制成的泡沫或颗粒（例如通过研磨））施用于受试者时，高比表面积可能有助于药物活性剂的递送或释放。 泡沫体也可表现出相当高的药物活性剂负荷。 在一些情况下，泡沫可以是微孔泡沫。 在一组实施方案中，使用超临界流体（例如超临界CO 2）产生泡沫。 例如，含有药物活性剂的泡沫体的前体可与发泡剂混合，然后降低压力，引起发泡剂膨胀，从而形成泡沫。 然后可以将泡沫研磨或研磨，或以其它方式加工形成颗粒。
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公开(公告)号：US08502132B2
公开(公告)日：2013-08-06
申请号：US13160254
申请日：2011-06-14
Applicant: David G. Grier , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
Inventor： David G. Grier , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
IPC: H05H3/00
CPC classification number: G03H1/08 , G03H1/22 , G03H1/2249 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T428/12486
Abstract: A method for manipulating a plurality of objects. The method includes the steps of providing a shaping source, applying the shaping source to create a spatially symmetric potential energy landscape, applying the potential energy landscape to a plurality of objects, thereby trapping at least a portion of the plurality of objects in the,24 potential energy landscape, spatially moving the potential energy landscape to manipulate the plurality of objects; and extinguishing the potential energy landscape, thereby causing the plurality of objects to move freely when the potential energy landscape is extinguished.
Abstract translation: 一种用于操纵多个物体的方法。 该方法包括以下步骤：提供成形源，施加成形源以产生空间对称的势能景观，将势能景观应用于多个物体，由此捕获多个物体的至少一部分，24 潜在的能量景观，空间移动潜在的能量景观来操纵多个物体; 并熄灭势能景观，从而当潜在能量景观熄灭时，使多个物体自由移动。
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公开(公告)号：US07973275B2
公开(公告)日：2011-07-05
申请号：US12343193
申请日：2008-12-23
Applicant: David G. Grier , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
Inventor： David G. Grier , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
IPC: H05H3/00
CPC classification number: G03H1/08 , G03H1/22 , G03H1/2249 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T428/12486
Abstract: Holographic optical traps using the forces exerted by computer-generated holograms to trap, move and otherwise transform mesoscopically textured materials. The efficacy of the present invention is based upon the quality and nature of the diffractive optical element used to create the traps and dynamically use them. Further a landscape of potential energy sites can be created and used to manipulate, sort and process objects.
Abstract translation: 全息光学陷阱使用由计算机生成的全息图施加的力来捕获，移动和以其他方式转换中观纹理材料。 本发明的功效基于用于产生捕获物并用于动态使用它们的衍射光学元件的质量和性质。 此外，可以创建潜在能量场地的景观，并用于操纵，排序和处理对象。
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15.发明申请公开(公告)号：US20060240591A1
公开(公告)日：2006-10-26
申请号：US11329579
申请日：2006-01-11
Applicant: David Grier , Ritesh Agarwal , Guihua Yu , Charles Lieber , Kosta Ladavac , Yael Roichman
Inventor： David Grier , Ritesh Agarwal , Guihua Yu , Charles Lieber , Kosta Ladavac , Yael Roichman
CPC classification number: B82B3/00 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C23C14/3407 , G03H1/2294 , G03H2001/0077 , G03H2210/30 , H01J37/3423 , H01L51/0002 , H01L51/0048 , H01L51/0052
Abstract: A system and method for manipulating and processing nanowires in solution with arrays of holographic optical traps. The system and method of the present invention is capable of creating hundreds of individually controlled optical traps with the ability to manipulate objects in three dimensions. Individual nanowires with cross-sections as small as 20 nm and lengths exceeding 20 μm are capable of being isolated, translated, rotated and deposited onto a substrate with holographic optical trap arrays under conditions where single traps have no discernible influence. Spatially localized photothermal and photochemical processes induced by the well-focused traps can also be used to melt localized domains on individual nanowires and to fuse nanowire junctions.
Abstract translation: 一种用于在全息光阱中阵列处理和处理溶液中的纳米线的系统和方法。 本发明的系统和方法能够创建数百个具有三维操纵对象能力的单独控制的光学陷阱。 具有小于20nm且长度超过20μm的横截面的单个纳米线能够在单陷阱没有明显影响的条件下被分离，平移，旋转并沉积到具有全息光阱阵列的基板上。 由聚焦陷阱诱导的空间定位的光热和光化学过程也可用于熔化单个纳米线上的局部结构域并融合纳米线结。
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Patent Agency Ranking
公开(公告)号：US08518702B2
公开(公告)日：2013-08-27
申请号：US13009405
申请日：2011-01-19
Applicant: Li Jiang , Oliver C. Mullins , Gale H. Gustavson , Christopher Harrison , Bhavani Raghuraman , Ronald E. G. Van Hal , Jimmy Lawrence , Kosta Ladavac , Albert Ballard Andrews , Timothy Gareth John Jones , Rogerio Tadeu Ramos
Inventor： Li Jiang , Oliver C. Mullins , Gale H. Gustavson , Christopher Harrison , Bhavani Raghuraman , Ronald E. G. Van Hal , Jimmy Lawrence , Kosta Ladavac , Albert Ballard Andrews , Timothy Gareth John Jones , Rogerio Tadeu Ramos
CPC classification number: G01N31/224 , C09K8/52 , C09K2208/20 , E21B49/08 , G01N21/77 , G01N21/78 , G01N2021/7763 , G01N2021/7773 , G01N2021/7786
Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.
Abstract translation: 描述了用于检测井下地层流体中的硫化氢的方法和相关装置和混合物。 检测混合物与井下的地层流体结合。 该检测混合物包括与形成金属硫化物的硫化氢反应的金属离子，以及带电的纳米粒子尺寸以抑制金属硫化物的显着聚集，从而能够对井下金属硫化物进行光谱检测。 然后用光谱询问合并的混合物和地层流体，以便检测金属硫化物的存在，从而指示地层流体中存在硫化氢。 混合物还包括螯合配体，用于在井下条件下维持混合物的耐热性。
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公开(公告)号：US20110278442A1
公开(公告)日：2011-11-17
申请号：US13160254
申请日：2011-06-14
Applicant: David G. GRIER , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
Inventor： David G. GRIER , Marco Polin , Sang-Hyuk Lee , Yael Roichman , Kosta Ladavac
IPC: H05H3/00
CPC classification number: G03H1/08 , G03H1/22 , G03H1/2249 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T428/12486
Abstract: A method for manipulating a plurality of objects. The method includes the steps of providing a shaping source, applying the shaping source to create a spatially symmetric potential energy landscape, applying the potential energy landscape to a plurality of objects, thereby trapping at least a portion of the plurality of objects in the potential energy landscape, spatially moving the potential energy landscape to manipulate the plurality of objects; and extinguishing the potential energy landscape, thereby causing the plurality of objects to move freely when the potential energy landscape is extinguished.
Abstract translation: 一种用于操纵多个物体的方法。 该方法包括以下步骤：提供成形源，施加成形源以产生空间对称势能景观，将势能景观应用于多个物体，从而将多个物体的至少一部分捕获在势能中 景观，空间移动势能景观来操纵多个物体; 并熄灭势能景观，从而当潜在能量景观熄灭时，使多个物体自由移动。
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公开(公告)号：US08058071B2
公开(公告)日：2011-11-15
申请号：US13009424
申请日：2011-01-19
Applicant: Li Jiang , Oliver C. Mullins , Gale H. Gustavson , Christopher Harrison , Bhavani Raghuraman , Ronald E. G. Van Hal , Jimmy Lawrence , Kosta Ladavac , Albert Ballard Andrews , Timothy Gareth John Jones , Rogerio Tadeu Ramos
Inventor： Li Jiang , Oliver C. Mullins , Gale H. Gustavson , Christopher Harrison , Bhavani Raghuraman , Ronald E. G. Van Hal , Jimmy Lawrence , Kosta Ladavac , Albert Ballard Andrews , Timothy Gareth John Jones , Rogerio Tadeu Ramos
IPC: G01N33/24
CPC classification number: G01N31/224 , C09K8/52 , C09K2208/20 , E21B49/08 , G01N21/77 , G01N21/78 , G01N2021/7763 , G01N2021/7773 , G01N2021/7786
Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.
Abstract translation: 描述了用于检测井下地层流体中的硫化氢的方法和相关装置和混合物。 检测混合物与井下的地层流体结合。 该检测混合物包括与形成金属硫化物的硫化氢反应的金属离子，以及带电的纳米粒子尺寸以抑制金属硫化物的显着聚集，从而能够对井下金属硫化物进行光谱检测。 然后用光谱询问合并的混合物和地层流体，以便检测金属硫化物的存在，从而指示地层流体中存在硫化氢。 混合物还包括螯合配体，用于在井下条件下维持混合物的耐热性。
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19.发明授权公开(公告)号：US07772543B2
公开(公告)日：2010-08-10
申请号：US11329579
申请日：2006-01-11
Applicant: David G. Grier , Ritesh Agarwal , Guihua Yu , Charles M. Lieber , Kosta Ladavac , Yael Roichman
Inventor： David G. Grier , Ritesh Agarwal , Guihua Yu , Charles M. Lieber , Kosta Ladavac , Yael Roichman
IPC: G01N21/63
CPC classification number: B82B3/00 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C23C14/3407 , G03H1/2294 , G03H2001/0077 , G03H2210/30 , H01J37/3423 , H01L51/0002 , H01L51/0048 , H01L51/0052
Abstract: A system and method for manipulating and processing nanowires in solution with arrays of holographic optical traps. The system and method of the present invention is capable of creating hundreds of individually controlled optical traps with the ability to manipulate objects in three dimensions. Individual nanowires with cross-sections as small as 20 nm and lengths exceeding 20 μm are capable of being isolated, translated, rotated and deposited onto a substrate with holographic optical trap arrays under conditions where single traps have no discernible influence. Spatially localized photothermal and photochemical processes induced by the well-focused traps can also be used to melt localized domains on individual nanowires and to fuse nanowire junctions.
Abstract translation: 一种用于在全息光阱中阵列处理和处理溶液中的纳米线的系统和方法。 本发明的系统和方法能够创建数百个具有三维操纵对象能力的单独控制的光学陷阱。 具有小于20nm且长度超过20μm的截面的单个纳米线能够在单陷阱没有明显影响的条件下被隔离，平移，旋转和沉积到具有全息光阱阵列的基板上。 由聚焦陷阱诱导的空间定位的光热和光化学过程也可用于熔化单个纳米线上的局部结构域并融合纳米线结。
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公开(公告)号：US07678222B2
公开(公告)日：2010-03-16
申请号：US11473398
申请日：2006-06-23
Applicant: David G. Grier , Kosta Ladavac , Joy M. Barker
Inventor： David G. Grier , Kosta Ladavac , Joy M. Barker
IPC: B29C65/00
CPC classification number: C09J5/00 , G03H2001/0077 , Y10S977/882
Abstract: A system and method for bonding and unbonding of small objects using small adhesive particles. The system and method includes the use of a plurality of optical tweezers to manipulate objects to be bonded and adhesive particles suspended in a fluid. The objects to be bonded (or unbonded) and the adhesive particles are positioned by lower power optical tweezers and then an intense bonding optical tweezer is activated to cause the adhesive to join the objects together (or used to unbond objects).
Abstract translation: 一种使用小粘合剂颗粒粘合和粘合小物体的系统和方法。 该系统和方法包括使用多个光学镊子来操纵待粘合的物体和悬浮在流体中的粘合剂颗粒。 待粘合（或未粘合）的物体和粘合剂颗粒通过较低功率的光学镊子定位，然后激活强力粘合光学镊子以使粘合剂将物体连接在一起（或用于将物体接合）。
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